Chlorothiazide
- Product Name
- Chlorothiazide
- CAS No.
- 58-94-6
- Chemical Name
- Chlorothiazide
- Synonyms
- Diuril;Flumen;Minzil;Urinex;Alurene;Diupres;Diurite;Diutrid;Salisan;Salunil
- CBNumber
- CB6756754
- Molecular Formula
- C7H6ClN3O4S2
- Formula Weight
- 295.72
- MOL File
- 58-94-6.mol
Chlorothiazide Property
- Melting point:
- 342-343°C
- Boiling point:
- 608.8±65.0 °C(Predicted)
- Density
- 1.7303 (rough estimate)
- refractive index
- 1.6100 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Very Slightly, Heated)
- pka
- 6.85, 9.45(at 25℃)
- color
- White to Off-White
- Water Solubility
- <0.1 g/100 mL at 19.5 ºC
- Merck
- 14,2168
- BCS Class
- 4
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- LogP
- -0.240
- CAS DataBase Reference
- 58-94-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Chlorothiazide(58-94-6)
- EPA Substance Registry System
- Chlorothiazide (58-94-6)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 42/43-20/21/22
- Safety Statements
- 36
- WGK Germany
- 2
- RTECS
- DK9450000
- HS Code
- 2935904000
- Hazardous Substances Data
- 58-94-6(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- C4911
- Product name
- Chlorothiazide
- Purity
- thiazide diuretic
- Packaging
- 50g
- Price
- $152.4
- Updated
- 2024/03/01
- Product number
- 1121005
- Product name
- Chlorothiazide
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- BP076
- Product name
- Chlorothiazide
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $243
- Updated
- 2022/05/15
- Product number
- 17909
- Product name
- Chlorothiazide
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 17909
- Product name
- Chlorothiazide
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $86
- Updated
- 2024/03/01
Chlorothiazide Chemical Properties,Usage,Production
Description
Chlorothiazide is a first-in-class thiazide diuretic initially discovered from its ability to inhibit carbonic anhydrase in vitro. As an antihypertensive agent, this thiazide increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.
Chemical Properties
Off-White Solid
Originator
Diuril,Merck Sharp and,US,1957
Uses
Chlorthiazide is a diuretic that causes the body to excrete excess fluid. This drug exhibits strong diuretic action during both acidosis and alkalosis. It is used for arterial hypertension, in edematous syndromes of various genesis, congestive effects in cardiovascular insufficiency, nephrosis and nephritis, and toxicosis. It is especially recommended for hypertonic illnesses. It lowers intraocular pressure in a number of cases.
Definition
ChEBI: Chlorothiazide is 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension. It has a role as a diuretic and an antihypertensive agent.
Manufacturing Process
(A) m-Chloroaniline (64 g, 0.5 mol) was added dropwise with stirring to 375
ml of chlorosulfonic acid in a 3-liter round bottom, 3-necked flask cooled in an
ice bath. Sodium chloride (350 g) was added portionwise over a period of 1 to2 hours and the mixture then heated gradually in an oil bath to 150°C. After 3
hours at 150° to 160°C, the flask was cooled thoroughly in an ice bath and
the contents treated with a liter of cold water. The product was extracted with
ether and the extract washed with water and dried over sodium sulfate.
After removal of ether on the steam bath, the residual 5-chloroaniline-2,4-
disulfonyl chloride, which may be crystallized from benzene-hexane MP 130°
to 132°C, was cooled in an ice bath and treated with 150 ml of 28%
ammonium hydroxide in a 2-liter Erlenmeyer flask. The mixture was heated
on the steam bath for 1 hour, cooled and the product collected on the filter,
washed with water and dried. Upon crystallization from dilute alcohol 5-
chloro-2,4-disulfamylaniline was obtained as colorless needles, MP 251° to
252°C.
(B) A solution of 88 g of 5-chloro-2,4-disulfamylaniline in 1.1 liters of 88%
formic acid was heated under reflux for 2 hours. After removal of 200 ml of
solvent by distillation, one liter of water was added and the product collected,
washed with water and dried. Crystallization from dilute alcohol afforded 6-
chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide as colorless needles, MP
342.5° to 343°C, as described in US Patent 2,809,194.
brand name
Diuril (Ovation).
General Description
Crystals; white powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Alkaline aqueous solutions will decompose on standing or heating .
Fire Hazard
Flash point data for Chlorothiazide are not available; however, Chlorothiazide is probably combustible.
Mechanism of action
The mechanism of action of Chlorothiazide is an interference with the renal tubular mechanism of electrolyte reabsorption. The diuretic action of chlorothiazide, like other drugs of this series, is caused by reduced absorption of sodium and chloride ions by the kidneys during their simultaneous, intense excretion from the organism.
Safety Profile
Moderately_toxic by intraperitoneal and intravenous routes. Mddly toxic by ingestion. Experimental reproductive effects. Has been implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of SOx NOx and Cl-.
Synthesis
Chlorothiazide, 1,1-dioxide 6-chloro-2H-1,2,4-benzothiadiazin-7-sulfonamide (21.3.3) is synthesized in the exact same manner, is all thiazide diuretics. 3- Chloroaniline (or 3-trifluoromethylaniline) undergoes sulfoylchlorination by chlorosulfonic acid, forming 4,6-sulfonochloride-3-chloroaniline (21.3.1), the reaction of which with ammonia gives 4,6-sulfonylamido-3-chloroaniline (21.3.2). Heating this with formamide leads to formation of chlorothiazide (21.3.3).
Veterinary Drugs and Treatments
In veterinary medicine, furosemide has largely supplanted the use
of thiazides as a general diuretic (edema treatment). Thiazides are
still used for the treatment of systemic hypertension,
nephrogenic
diabetes insipidus, and to help prevent the recurrence of calcium
oxalate uroliths in dogs.
Chlorothiazide is approved for use in dairy cattle for the treatment
of post parturient udder edema, but the veterinary labeled
product has been discontinued in the USA.
Chlorothiazide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Chlorothiazide manufacturers
- Product
- Chlorothiazide 58-94-6
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 98%-102%;EP
- Supply Ability
- 500kgs
- Release date
- 2021-07-06
- Product
- Chlorothiazide 58-94-6
- Price
- US $1.30/g
- Min. Order
- 100g
- Purity
- 99.99%
- Supply Ability
- 5ton/Month
- Release date
- 2021-11-26
- Product
- Chlorothiazide 58-94-6
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-21