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Salicylamide

Product Name
Salicylamide
CAS No.
65-45-2
Chemical Name
Salicylamide
Synonyms
OHB;Acket;Samid;Cidal;Salrin;sr4326;Anamid;h.p.34;Oramid;Algamon
CBNumber
CB4854078
Molecular Formula
C7H7NO2
Formula Weight
137.14
MOL File
65-45-2.mol
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Salicylamide Property

Melting point:
140-144 °C(lit.)
Boiling point:
270°C
Density 
1,175 g/cm3
refractive index 
1.5323 (estimate)
Flash point:
181°C/14mm
storage temp. 
Inert atmosphere,Room Temperature
solubility 
methanol: 0.1 g/mL, clear
form 
Crystalline Powder
pka
pKa 8.13(H2O t = 37) (Uncertain)
color 
White
Odor
Odorless
PH Range
5 (0.2% aq soln)
Water Solubility 
<0.1 g/100 mL at 20 ºC
Decomposition 
270°C
Merck 
14,8328
BRN 
742439
Stability:
Stable. Light sensitive. Incompatible with strong bases, strong oxidizing agents.
InChIKey
SKZKKFZAGNVIMN-UHFFFAOYSA-N
CAS DataBase Reference
65-45-2(CAS DataBase Reference)
NIST Chemistry Reference
Benzamide, 2-hydroxy-(65-45-2)
EPA Substance Registry System
o-Hydroxybenzamide (65-45-2)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38-20/21/22
Safety Statements 
26-36
RIDADR 
3249
WGK Germany 
3
RTECS 
VN6475000
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29214300
Hazardous Substances Data
65-45-2(Hazardous Substances Data)
Toxicity
LD50 orally in mice: 1.4 g/kg (Hart)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
84230
Product name
Salicylamide
Purity
puriss., ≥99.0% (T)
Packaging
1kg
Price
$60.4
Updated
2021/03/22
Sigma-Aldrich
Product number
1608000
Product name
Salicylamide
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$366
Updated
2021/03/22
TCI Chemical
Product number
S0006
Product name
Salicylamide
Purity
>98.0%(T)
Packaging
25g
Price
$15
Updated
2021/03/22
TCI Chemical
Product number
S0006
Product name
Salicylamide
Purity
>98.0%(T)
Packaging
500g
Price
$56
Updated
2021/03/22
Alfa Aesar
Product number
A10797
Product name
Salicylamide, 98%
Packaging
250g
Price
$26
Updated
2020/06/24
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Salicylamide Chemical Properties,Usage,Production

Description

Salicylamide is less acidic (pKa 8.2) than other salicylic acid derivatives. Although poorly soluble in water, stable solutions can be formed at pH 9 through ionization of the phenolic group. It is absorbed from the GI tract on oral administration and is rapidly metabolized to inactive metabolites by intestinal mucosa, but not by hydrolysis. Activity appears to reside in the intact molecule. Salicylamide is approximately 40 to 55% plasma protein bound, and it competes with other salicylates and acetaminophen for glucuronide conjugation, decreasing the extent of conjugation of these other drugs.

Chemical Properties

white or light pink crystals or powder

Uses

Medicine (analgesic).

Uses

salicylamide is an analgesic, fungicide, and anti-inflammatory ingredient used to soothe the skin. Salicylamide is an aromatic amide.

Definition

ChEBI: The simplest member of the class of salicylamides derived from salicylic acid.

General Description

Salicylamide, o-hydroxybenzamide, is a derivative of salicylicacid that is fairly stable to heat, light, and moisture. Itreportedly exerts a moderately quicker and deeper analgesiceffect than aspirin because of quicker CNS penetration. Its metabolismdiffers from aspirin, because it is not metabolized tosalicylic acid but rather excreted exclusively as the ether glucuronideor sulfate. Thus, as a result of lack of contributionfrom salicylic acid, it has a lower analgesic and antipyretic efficacythan that of aspirin. However, it can be used in place ofsalicylates for patients with a demonstrated sensitivity to salicylates.It is also excreted much more rapidly than other salicylates,which accounts for its lower toxicity. It is available inseveral nonprescription products, in combination with acetaminophenand phenyltoloxamine (e.g., Rid-A Pain compound,Cetazone T, Dolorex, Ed-Flex, Lobac) or with aspirin,acetaminophen, and caffeine (e.g., Saleto, BC Powder).

General Description

Odorless white or slightly pink crystals. Bitter taste, leaves a sensation of warmth on the tongue. pH (saturated aqueous solution at 82°F) about 5. Sublimation begins at the melting point.

Air & Water Reactions

Salicylamide darkens on exposure to air. . Insoluble in water.

Reactivity Profile

Salicylamide is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). Salicylamide may be sensitive to prolonged exposure to light.

Fire Hazard

Flash point data for Salicylamide are not available; however, Salicylamide is probably combustible.

Clinical Use

Whereas salicylamide is reported to be as effective as aspirin as an analgetic/antipyretic and is effective in relieving pain associated with arthritic conditions, it does not appear to possess useful anti-inflammatory activity. Thus, indications for the treatment of arthritic disease states are unwarranted, and its use is restricted to the relief of minor aches and pain at a dosage of 325 to 650 mg three or four times per day. Its effects in humans are not reliable, however, and its use is not widely recommended.

Purification Methods

Crystallise the amide from water or repeatedly from CHCl3 [Nishiya et al. J Am Chem Soc 108 3880 1986]. [Beilstein 10 IV 169.] The anilide [87-17-2] M 213.2, m 135o crystallises from H2O. [Beilstein 12 H 500, 12 I 268, 12 II 256, 12 944.]

Salicylamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Salicylamide Suppliers

Nanjing Jiangyan Chemical Co., Ltd.
Tel
15850530966
Email
13912946682@139.com
Country
China
ProdList
6
Advantage
58
Panjin pulefei trading co. LTD
Tel
0427-6572597-
Email
873272860@qq.com
Country
China
ProdList
14
Advantage
58
JinJin Le Chemical Co., Ltd
Tel
10106090
Email
jinjinlechem@163.com
Country
China
ProdList
10000
Advantage
58
Henan Huawen Chemical Co., Ltd
Tel
0370-2070108-
Fax
QQ:2712427897
Email
2712427897@qq.com
Country
China
ProdList
8899
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96500
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820-
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1401
Advantage
62
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057-
Fax
0757-86311057
Email
sales.gd@hwrkchemical.com
Country
China
ProdList
17295
Advantage
55
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View Lastest Price from Salicylamide manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Salicylamide 65-45-2
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-11-04
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Salicylamide 65-45-2
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%-102%; USP
Supply Ability
10 TONS
Release date
2021-06-30
Baoji Guokang Bio-Technology Co., Ltd.
Product
Salicylamide 65-45-2
Price
US $45.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
10T
Release date
2021-06-03

65-45-2, SalicylamideRelated Search:


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