5-Acetylsalicylamide
- Product Name
- 5-Acetylsalicylamide
- CAS No.
- 40187-51-7
- Chemical Name
- 5-Acetylsalicylamide
- Synonyms
- 5-Acetyl;LABEIM-I;JACS-40187-51-7;5-Acetylsalicyamide;5-Acetosalicylamide;5-Acetylsalicylamid;5 cetylsalicylamide;5-ACETYLSALICYLAMIDE;Aliskiren Impurity 59;Labetalol Impurity 22
- CBNumber
- CB1472008
- Molecular Formula
- C9H9NO3
- Formula Weight
- 179.17
- MOL File
- 40187-51-7.mol
5-Acetylsalicylamide Property
- Melting point:
- 220-222 °C(lit.)
- Boiling point:
- 311.69°C (rough estimate)
- Density
- 1.2822 (rough estimate)
- refractive index
- 1.5600 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 6.57±0.18(Predicted)
- form
- Solid
- color
- White to Light Brown
- InChI
- InChI=1S/C9H9NO3/c1-5(11)6-2-3-8(12)7(4-6)9(10)13/h2-4,12H,1H3,(H2,10,13)
- InChIKey
- LWAQTCWTCCNHJR-UHFFFAOYSA-N
- SMILES
- C(N)(=O)C1=CC(C(C)=O)=CC=C1O
- CAS DataBase Reference
- 40187-51-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38-22
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- CU8702280
- HS Code
- 2924.29.7790
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A1156
- Product name
- 5-Acetylsalicylamide
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $42
- Updated
- 2025/07/31
- Product number
- A187945
- Product name
- 5-Acetylsalicylamide
- Packaging
- 5g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- F686
- Product name
- 5-Acetylsalicylamide
- Packaging
- 10g
- Price
- $18
- Updated
- 2021/12/16
- Product number
- J97900
- Product name
- 5-Acetylsalicylamide
- Packaging
- 100g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 42758
- Product name
- 5-Acetylsalicylamide
- Packaging
- 5G
- Price
- $610
- Updated
- 2021/12/16
5-Acetylsalicylamide Chemical Properties,Usage,Production
Chemical Properties
cream to beige powder
Uses
5-Acetylsalicylamide is used as a reagent in the synthesis of Phosphotyrosine(P365000) peptidomimetic prodrugs, compounds that have similar structure to small protein-like chains in order to mimic peptide activities. 5-Acetylsalicylamide is also used as a reagent to prepare 4-aminopiperidine ureas, compounds that act as human β3 adrenergic receptor agonists.
Synthesis
75-36-5
65-45-2
40187-51-7
1) Preparation of NaCl-AlCl3 low melting point mixed molten salt system: assemble a mechanical stirrer, condenser tube (connected to the tail gas HCl absorption device), 0~200°C thermometer and constant pressure dropping funnel in a 100 ml three-neck flask. The device was placed in a constant temperature oil bath. Quickly weigh 0.0648 mol (~8.64 g) of anhydrous aluminum chloride and 0.0648 mol (~3.79 g) of sodium chloride into the flask, turn on the mechanical stirring, and heat to 140°C until the solids are completely melted and the temperature is stable. Note: After about 25 minutes, the anhydrous aluminum chloride and sodium chloride should be in a molten state. 2) With stirring, weigh 0.036 mol (about 5.00 g) of salicylamide into a flask that has been heated to 140°C and allowed to melt, keeping the temperature in the flask stable. 3) Weigh 0.0432 mol (about 3.39 g) of acetyl chloride and add it slowly dropwise through a constant pressure dropping funnel into the reaction system for about 10 minutes. The reaction temperature was maintained at 140 °C and continued for 0.5 h to ensure complete reaction. The reaction was carried out in a NaCl-AlCl3 low melting point mixed molten salt system. 4) Immediately after completion of the reaction, 60 mL of acidic solution (consisting of 1 mL of concentrated hydrochloric acid and 59 mL of ice-water mixture) was added slowly (uniformly over about 5 min) to the system, at which time a yellowish solid was produced. After adding the acidic solution, continue stirring at room temperature for 30 minutes until no more yellowish solids are generated to obtain the suspension. 5) The suspension was filtered, the light yellow solid was collected, washed three times (5 mL each time) with hot water at 80°C, and then dried at 80°C for 5 hours to obtain the crude product. 6) The crude product was dissolved in 20 mL of ethanol and heated to reflux temperature to dissolve it completely. Subsequently, recrystallization was carried out in an ice bath, and the precipitated crystals were filtered and dried at 80 °C for 5 h. The final product was 5-acetyl-2-hydroxybenzamide as a white solid (purity ≥98.1%) in 92.2% yield.
References
[1] Heterocyclic Communications, 2013, vol. 19, # 1, p. 23 - 28
[2] Patent: CN104557604, 2017, B. Location in patent: Paragraph 0039; 0040; 0041; 0042; 0043-0057; 0068-0075
[3] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1952, vol. 234, p. 1058
5-Acetylsalicylamide Preparation Products And Raw materials
Raw materials
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View Lastest Price from 5-Acetylsalicylamide manufacturers
- Product
- 5-Acetylsalicylamide 40187-51-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-10-25
- Product
- 5-Acetylsalicylamide 40187-51-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-12
- Product
- 5-Acetylsalicylamide 40187-51-7
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-04-27