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KANAMYCIN B SULFATE

Product Name
KANAMYCIN B SULFATE
CAS No.
29701-07-3
Chemical Name
KANAMYCIN B SULFATE
Synonyms
Kanendos;Stereocidin;BEKANAMYCIN SULFATE;KANAMYCIN B SULFATE;Aminodeoxybekanamycin;Kanamycin B sulfate CRS;BEKANAMYCIN SULFATE SALT;KANAMYCIN B SULFATE SALT;aminodeoxykanamycinsulfate;Kanamycin B Sulfate, EvoPure
CBNumber
CB6761792
Molecular Formula
C18H39N5O14S
Formula Weight
581.59
MOL File
29701-07-3.mol
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KANAMYCIN B SULFATE Property

storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL, clear, colorless
form 
powder
Merck 
13,5299
BRN 
5235274
Stability:
Hygroscopic
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Safety

Safety Statements 
22-24/25
WGK Germany 
2
RTECS 
WK1976500
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B5264
Product name
Kanamycin B sulfate salt
Purity
aminoglycoside antibiotic
Packaging
100mg
Price
$104
Updated
2024/03/01
Sigma-Aldrich
Product number
B5264
Product name
Kanamycin B sulfate salt
Purity
aminoglycoside antibiotic
Packaging
1g
Price
$509
Updated
2024/03/01
Sigma-Aldrich
Product number
B5264
Product name
Kanamycin B sulfate salt
Purity
aminoglycoside antibiotic
Packaging
250mg
Price
$176
Updated
2024/03/01
Sigma-Aldrich
Product number
K0100000
Product name
Kanamycin B sulfate salt
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
k0100000
Price
$220
Updated
2024/03/01
Usbiological
Product number
015282
Product name
Kanamycin B Sulfate
Packaging
25mg
Price
$446
Updated
2021/12/16
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KANAMYCIN B SULFATE Chemical Properties,Usage,Production

Originator

Kanendomycin,Meiji Seika,Japan,1969

Uses

Antibiotic complex produced by Streptomyces kanamyceticus Okami & Umezawa from Japanese soil. Comprised of three components, kanamycin A, the major component, and kanamycins B and C, two minor congeners. Antibacterial.

Definition

ChEBI: Bekanamycin sulfate is an aminoglycoside sulfate salt. It is functionally related to a kanamycin B.

Manufacturing Process

200 liters of the medium containing 2.0% starch, 1.0% soybean meal, 0.05% KCl, 0.05% MgSO4·7H2O, 0.3% NaCl, 0.2% NaNO3 was placed in the 400 liter fermenter, the pH was adjusted to 7.5, and the medium was then sterilized (pH after the sterilization was 7.0) for 30 minutes at 120°C, inoculated with 1,000 ml of 40 hour shake-cultured broth of S. kanamyceticus (a selected subculture of K2-J strain) and tank-cultured at 27°-29°C. As antifoam,soybean oil (0.04%)and silicone (0.04%) were added. The broth after 48 hours was found to contain 250 mcg/ml of kanamycin.
A portion (950 ml) of the rich eluate was adjusted to pH 6.0 by the addition of sulfuric acid. Ultrawet K (7.0 g) in 70 ml water was added slowly to the neutralized eluate to precipitate kanamycin B dodecylbenzenesulfonate which was collected by filtration after adding filter aid (Dicalite). The cake was washed with water and extracted with 100 ml methanol. After filtering and washing with methanol, sulfuric acid was added to the filtrate until no more kanamycin B sulfate precipitated. After addition of an equal volume of acetone to provide more complete precipitation, the kanamycin B sulfate was collected by filtration, washed with methanol and dried in vacuo at 50°C.

Therapeutic Function

D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1- 6)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1-4)]-2-deoxy sulfate (1:1)

Purification Methods

A small quantity of kanamycin B (24mg) can be purified on a small Dowex-1 x 2 column (6 x 50mm); the required fraction is evaporated to dryness and the residue crystallised from EtOH containing a small amount of H2O. [Umezawa et al. Bull Chem Soc Jpn 42 537 1969.] It has been crystallised from H2O by dissolving ~1g in H2O (3mL), adding Me2NCHO (3mL) and setting aside at 4o overnight. The needles are collected and dried to constant weight at 130o. It has also been recrystallised from aqueous EtOH. It is slightly soluble in CHCl3 and isoPrOH. [IR: Wakazawa et al. J Antibiot 14A 180, 187 1961, Ito et al. J Antibiot 17 A 189 1964, Beilstein 18 III/IV 7631.]

KANAMYCIN B SULFATE Preparation Products And Raw materials

Raw materials

Preparation Products

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KANAMYCIN B SULFATE Suppliers

Shanghai Boyle Chemical Co., Ltd.
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86-21-57758967
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China
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J & K SCIENTIFIC LTD.
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jkinfo@jkchemical.com
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Chemsky (shanghai) International Co.,Ltd
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021-50135380
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Beijing HuaMeiHuLiBiological Chemical
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Shanghai Kewel Chemical Co., Ltd.
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UHN Shanghai Research & Development Co., Ltd.
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29701-07-3, KANAMYCIN B SULFATERelated Search:


  • aminodeoxykanamycinsulfate
  • kanamycinb,sulfate(1:1)(salt)
  • BEKANAMYCIN SULFATE
  • BEKANAMYCIN SULFATE SALT
  • KANAMYCIN B SULFATE
  • KANAMYCIN B SULFATE SALT
  • Aminodeoxybekanamycin
  • Kanamycin B sulfate CRS
  • KANAMYCIN B SULFATE USP/EP/BP
  • Kanendos
  • Stereocidin
  • kanamycin B sulfate (Amikacin EP Impurity D)
  • Kanamycin B Sulfate, EvoPure
  • 29701-07-3
  • 29701-10-3
  • C18H37N5O10H2O4S
  • C18H37N5O10H2SO4
  • C18H39N5O14S
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