(S)-(+)-1-Methyl-3-pyrrolidinol
Uses- Product Name
- (S)-(+)-1-Methyl-3-pyrrolidinol
- CAS No.
- 104641-59-0
- Chemical Name
- (S)-(+)-1-Methyl-3-pyrrolidinol
- Synonyms
- CAS:104641-59-0;CHEMPACIFIC 38130;Methyl-3-Pyrrolidinol;Glycopyrrolate Impurity 8;Glycopyrrolate Impurity 21;(S)-1-METHYLPYRROLIDIN-3-OL;(S)-N-Methyl-3-pyrrolidinol;(S)-1-METHYL-3-PYRROLIDINOL;(3S)-1-methylpyrrolidin-3-ol;(R)-3-Hydroxy-1-methylpyr...
- CBNumber
- CB6765260
- Molecular Formula
- C5H11NO
- Formula Weight
- 101.15
- MOL File
- 104641-59-0.mol
(S)-(+)-1-Methyl-3-pyrrolidinol Property
- Boiling point:
- 181-182 °C(lit.)
- alpha
- 6 º (c=1%, chloroform)
- Density
- 0.993 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.4660(lit.)
- Flash point:
- 192 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Liquid
- pka
- 14.95±0.20(Predicted)
- color
- Colorless to yellow to brown
- optical activity
- [α]20/D +6°, c = 1 in chloroform
- Sensitive
- Air Sensitive & Hygroscopic
- BRN
- 4349394
- CAS DataBase Reference
- 104641-59-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
N-Bromosuccinimide Price
- Product number
- M1938
- Product name
- (S)-1-Methyl-3-pyrrolidinol
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $119
- Updated
- 2025/07/31
- Product number
- M1938
- Product name
- (S)-1-Methyl-3-pyrrolidinol
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $356
- Updated
- 2025/07/31
- Product number
- M329040
- Product name
- (S)-1-Methyl-3-pyrrolidinol
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- M329040
- Product name
- (S)-1-Methyl-3-pyrrolidinol
- Packaging
- 5g
- Price
- $495
- Updated
- 2021/12/16
- Product number
- 092713
- Product name
- (S)-(+)-1-Methyl-3-pyrrolidinol
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $22
- Updated
- 2021/12/16
(S)-(+)-1-Methyl-3-pyrrolidinol Chemical Properties,Usage,Production
Uses
(S)-1-Methyl-3-pyrrolidinol is a useful synthetic intermediate. It is used to prepare diaryl acylaminopyrimidines as adenosine A2A antagonists. It is also used to synthesize (alkoxyamino)(pyridinylamino)pyrazinecarbonitriles as selective checkpoint kinase 1 (CHK1) inhibitors with oral antitumor activities.
Uses
(S)-1-Methyl-3-pyrrolidinol is a useful synthetic intermediate. It is used to prepare diaryl acylaminopyrimidines as adenosine A2A antagonists. It is also used to synthesize (alkoxyamino)(pyridinylamino)pyrazinecarbonitriles as selective checkpoint kinase 1 (CHK1) inhibitors with oral antitumor activities.
Synthesis
1104643-24-4
104641-59-0
The general procedure for synthesizing (S)-(+)-1-methyl-3-hydroxypyrrolidine from the compound (CAS:1104643-24-4) was as follows: 112 g of S-3-tert-butoxy-N-methylpyrrolidine was dissolved in 300 mL of dichloroethane. Subsequently, 117 g of concentrated hydrochloric acid (1.16 mol) was slowly added dropwise to the above solution and the dropwise process lasted for 1 hour. The reaction solution was stirred at 55-60°C for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and diluted by adding 50 g of water. After separation of the organic layer, the aqueous layer was concentrated under reduced pressure. To the concentrated residue, 500 mL of isopropanol was added, followed by the slow addition of 46.83 g (1.16 mol) of sodium hydroxide, the addition process lasted for 1 hr, followed by stirring for 5 hr at room temperature. The solid phase inorganic material was removed by filtration and the filtrate was concentrated under reduced pressure to give a final 45.3 g of S-1-methyl-3-pyrrolidinol (total two-step yield of 58%, chemical purity of 99.36%, optical purity of 99.31% ee). The product was characterized by 1H NMR (CDCl3, 400 MHz): δ 1.73 (m, 1H), 2.20 (m, 2H), 2.34 (s, 3H), 2.47 (dd, J = 5.2,10 Hz, 1H), 2.64 (d, J = 10 Hz, 1H), 2.85 (m, 1H), 4.32 (m, 1H) ppm.
References
[1] Patent: WO2009/11551, 2009, A2. Location in patent: Page/Page column 15
(S)-(+)-1-Methyl-3-pyrrolidinol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-(+)-1-Methyl-3-pyrrolidinol manufacturers
- Product
- (S)-(+)-1-Methyl-3-pyrrolidinol 104641-59-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- (S)-(+)-1-Methyl-3-pyrrolidinol 104641-59-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-07-04