(S)-(+)-1-Methyl-3-pyrrolidinol

Uses

Product Name: (S)-(+)-1-Methyl-3-pyrrolidinol
CAS No.: 104641-59-0
Chemical Name: (S)-(+)-1-Methyl-3-pyrrolidinol
Synonyms: CAS:104641-59-0;CHEMPACIFIC 38130;Methyl-3-Pyrrolidinol;Glycopyrrolate Impurity 8;Glycopyrrolate Impurity 21;(S)-1-METHYLPYRROLIDIN-3-OL;(S)-N-Methyl-3-pyrrolidinol;(S)-1-METHYL-3-PYRROLIDINOL;(3S)-1-methylpyrrolidin-3-ol;(R)-3-Hydroxy-1-methylpyr...
CBNumber: CB6765260
Molecular Formula: C5H11NO
Formula Weight: 101.15
MOL File: 104641-59-0.mol

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(S)-(+)-1-Methyl-3-pyrrolidinol Property

Boiling point:: 181-182 °C(lit.)
alpha: 6 º (c=1%, chloroform)
Density: 0.993 g/mL at 25 °C(lit.)
refractive index: n20/D 1.4660(lit.)
Flash point:: 192 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Liquid
pka: 14.95±0.20(Predicted)
color: Colorless to yellow to brown
optical activity: [α]20/D +6°, c = 1 in chloroform
Sensitive: Air Sensitive & Hygroscopic
BRN: 4349394
CAS DataBase Reference: 104641-59-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: NA 1993 / PGIII
WGK Germany: 3
RTECS: TM9570000
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M1938
Product name: (S)-1-Methyl-3-pyrrolidinol
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $119
Updated: 2025/07/31

TCI Chemical

Product number: M1938
Product name: (S)-1-Methyl-3-pyrrolidinol
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $356
Updated: 2025/07/31

TRC

Product number: M329040
Product name: (S)-1-Methyl-3-pyrrolidinol
Packaging: 1g
Price: $130
Updated: 2021/12/16

TRC

Product number: M329040
Product name: (S)-1-Methyl-3-pyrrolidinol
Packaging: 5g
Price: $495
Updated: 2021/12/16

Oakwood

Product number: 092713
Product name: (S)-(+)-1-Methyl-3-pyrrolidinol
Purity: 95+%
Packaging: 250mg
Price: $22
Updated: 2021/12/16

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(S)-(+)-1-Methyl-3-pyrrolidinol Chemical Properties,Usage,Production

Uses

(S)-1-Methyl-3-pyrrolidinol is a useful synthetic intermediate. It is used to prepare diaryl acylaminopyrimidines as adenosine A2A antagonists. It is also used to synthesize (alkoxyamino)(pyridinylamino)pyrazinecarbonitriles as selective checkpoint kinase 1 (CHK1) inhibitors with oral antitumor activities.

Uses

(S)-1-Methyl-3-pyrrolidinol is a useful synthetic intermediate. It is used to prepare diaryl acylaminopyrimidines as adenosine A2A antagonists. It is also used to synthesize (alkoxyamino)(pyridinylamino)pyrazinecarbonitriles as selective checkpoint kinase 1 (CHK1) inhibitors with oral antitumor activities.

Synthesis

1104643-24-4

104641-59-0

The general procedure for synthesizing (S)-(+)-1-methyl-3-hydroxypyrrolidine from the compound (CAS:1104643-24-4) was as follows: 112 g of S-3-tert-butoxy-N-methylpyrrolidine was dissolved in 300 mL of dichloroethane. Subsequently, 117 g of concentrated hydrochloric acid (1.16 mol) was slowly added dropwise to the above solution and the dropwise process lasted for 1 hour. The reaction solution was stirred at 55-60°C for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and diluted by adding 50 g of water. After separation of the organic layer, the aqueous layer was concentrated under reduced pressure. To the concentrated residue, 500 mL of isopropanol was added, followed by the slow addition of 46.83 g (1.16 mol) of sodium hydroxide, the addition process lasted for 1 hr, followed by stirring for 5 hr at room temperature. The solid phase inorganic material was removed by filtration and the filtrate was concentrated under reduced pressure to give a final 45.3 g of S-1-methyl-3-pyrrolidinol (total two-step yield of 58%, chemical purity of 99.36%, optical purity of 99.31% ee). The product was characterized by 1H NMR (CDCl3, 400 MHz): δ 1.73 (m, 1H), 2.20 (m, 2H), 2.34 (s, 3H), 2.47 (dd, J = 5.2,10 Hz, 1H), 2.64 (d, J = 10 Hz, 1H), 2.85 (m, 1H), 4.32 (m, 1H) ppm.

References

[1] Patent: WO2009/11551, 2009, A2. Location in patent: Page/Page column 15

(S)-(+)-1-Methyl-3-pyrrolidinol Preparation Products And Raw materials

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View Lastest Price from (S)-(+)-1-Methyl-3-pyrrolidinol manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: (S)-(+)-1-Methyl-3-pyrrolidinol 104641-59-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: (S)-(+)-1-Methyl-3-pyrrolidinol 104641-59-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-07-04

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CHEMPACIFIC 38130

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(S)-(+)-1-METHYL-3-HYDROXYPYRROLIDINE, 98%, EE 99%

(3S)-1-methyl-3-pyrrolidinol

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(S)-1-Methyl-3-pyrrolidinol&gt

3-Pyrrolidinol, 1-methyl-, (3S)-

(S)-(+)-1-Methyl-3-pyrrillidinol

CAS:104641-59-0

(<i>S</i>)-(+)-1-Methyl-3-pyrrolidinol

104641-59-0

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