ChemicalBook > CAS DataBase List > N-(3-HYDROXYPROPYL)PHTHALIMIDE

N-(3-HYDROXYPROPYL)PHTHALIMIDE

Product Name: N-(3-HYDROXYPROPYL)PHTHALIMIDE
CAS No.: 883-44-3
Chemical Name: N-(3-HYDROXYPROPYL)PHTHALIMIDE
Synonyms: AURORA 4786;2-(3-Hydroxypropyl);3-PHTHALIMIDO-1-PROPANOL;N-(3-HYDROXYPROPYL)PHTHALIMIDE;N-(3-Hydroxypropyl)phthaliMide 95%;N-(3-Hydroxypropyl)phthalimide,99%;N-(3-Hydroxypropyl) phthalimide-98%;N-(3-HYDROXYPROPYL)PHTHALIMIDE, 95+%;N-(3-Hydroxypropyl)phthalimide;2-(3-hydroxypropyl)isoindole-1,3-dione
CBNumber: CB6767017
Molecular Formula: C11H11NO3
Formula Weight: 205.21
MOL File: 883-44-3.mol

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N-(3-HYDROXYPROPYL)PHTHALIMIDE Property

Melting point:: 74-76 °C (lit.)
Boiling point:: 376.5±25.0 °C(Predicted)
Density: 1.331±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 14.88±0.10(Predicted)
form: Crystalline Powder
color: White
BRN: 158489
CAS DataBase Reference: 883-44-3(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29251900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 103063
Product name: N-(3-Hydroxypropyl)phthalimide
Purity: 95%
Packaging: 25g
Price: $67.3
Updated: 2023/06/20

TRC

Product number: H961868
Product name: N-(3-Hydroxypropyl)phthalimide
Packaging: 2.5g
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: V8607
Product name: N-(3-Hydroxypropyl)phthalimide
Packaging: 25g
Price: $67
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0124881
Product name: N-(3-HYDROXYPROPYL)PHTHALIMIDE
Purity: 95.00%
Packaging: 25G
Price: $1130.77
Updated: 2021/12/16

Ambeed

Product number: A139927
Product name: 2-(3-Hydroxypropyl)isoindoline-1,3-dione
Purity: 95%
Packaging: 1g
Price: $6
Updated: 2021/12/16

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N-(3-HYDROXYPROPYL)PHTHALIMIDE Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder

Uses

N-(3-Hydroxypropyl)phthalimide was used as standard in the synthesis of phthalimide derivatives at high-temperature, high-pressure and H₂O/EtOH mixtures as the solvent. It may be used in the synthesis of hydrophilic phosphorylcholine-containing polymer, poly-2-[3-(methacryloylamino)propylammonio] ethyl 3-aminopropyl phosphate.

Definition

ChEBI: N-(3-Hydroxypropyl)phthalimide is a member of phthalimides.

General Description

N-(3-Hydroxypropyl)phthalimide is ω-Hydroxyalkylphthalimide and is prepared by mixing phthalic anhydride and propanolamine and by heating at 160-180 °C for 4 hours.

Synthesis

85-44-9

156-87-6

883-44-3

3-Amino-1-propanol (10.0 g, 133.1 mmol) was dissolved in anhydrous toluene (100 mL). Phthalic anhydride (19.7 g, 133.1 mmol) was added to the solution under argon protection. The reaction mixture was heated with stirring at 125 °C for 6.5 hours. Upon completion of the reaction, it was cooled to room temperature and the solvent was removed by vacuum evaporation to afford the white powdery product 2-(3-hydroxypropyl)isodihydroindole-1,3-dione (31.7 g, quantitative yield), which could be used in subsequent steps without further purification.

References

[1] Beilstein Journal of Organic Chemistry, 2017, vol. 13, p. 644 - 647
[2] Organic and Biomolecular Chemistry, 2014, vol. 12, # 32, p. 6094 - 6104
[3] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 16, p. 5903 - 5914
[4] Chemistry - A European Journal, 2014, vol. 20, # 44, p. 14256 - 14260
[5] Chemical Papers, 2017, vol. 71, # 11, p. 2293 - 2299

N-(3-HYDROXYPROPYL)PHTHALIMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(3-HYDROXYPROPYL)PHTHALIMIDE Suppliers

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883-44-3, N-(3-HYDROXYPROPYL)PHTHALIMIDERelated Search:

N-(2,3-EPOXYPROPYL)PHTHALIMIDE (2S)-4-(1,3-Dioxoisoindolin-2-yl)-2-hydroxybutanoic acid N-(3-HYDROXYPROPYL)PHTHALIMIDE Disperse Blue 60 3-PHTHALIMIDOPROPIONIC ACID Isoindoline Methyl3-O-benzyl-6-O-(2,3,4-tri-O-benzyl-a-L-fucopyranosyl)-2-deoxy-2-phthalimido-b-D-glucopyranoside Methyl 4,6-O-Benzylidene-2-deoxy-2-N-phthalimido-b-D-glucopyranoside BROMO 2-DEOXY-2-N-PHTHALIMIDO-3,4,6-TRI-O-ACETYL-A, B-D-GLUCOPYRANOSIDE 2-ETHOXYCARBONYL-ETHYL-PHTHALIMIDE Methyl 3-O-Benzyl-4,6-O-benzylidene-2-deoxy-2-N-phthalimido-b-D-glucopyranoside METHYL 3,4,6-TRI-O-ACETYL-2-DEOXY-2-PHTHALIMIDO-1-THIO-BETA-D-GLUCOPYRANOSIDE Methyl 3,6-Di-O-benzyl-2-deoxy-2-N-phthalimido-b-D-glucopyranoside 1,3,4,6-TETRA-O-ACETYL-2-DEOXY-2-PHTHALIMIDO-BETA-D-GLUCOPYRANOSE 2-PHTHALIMIDOLACTOSAMINE, HEPTAACETATE Methyl 2-Deoxy-2-N-phthalimido-b-D-glucopyranoside 2,6-DI(OXIRAN-2-YLMETHYL)-1,2,3,5,6,7-HEXAHYDROPYRROLO[3,4-F]ISOINDOLE-1,3,5,7-TETRAONE N-(3-Chloro-2-hydroxypropyl)phthalimide

3-PHTHALIMIDO-1-PROPANOL

AURORA 4786

N-(3-HYDROXYPROPYL)PHTHALIMIDE

2-(3-hydroxypropyl)-2,3-dihydro-1H-isoindole-1,3-dione

2-(3-Hydroxypropyl)-1H-isoindole-1,3(2H)-dione

2-(3-Hydroxypropyl)-2H-isoindole-1,3-dione

2-(3-Hydroxypropyl)isoindoline-1,3-dione

N-(3-Hydroxypropyl)phthalimide,99%

1H-Isoindole-1,3(2H)-dione, 2-(3-hydroxypropyl)-

N-(3-Hydroxypropyl)phthaliMide 95%

2-(3-Hydroxypropyl)

N-(3-Hydroxypropyl) phthalimide-98%

N-(3-HYDROXYPROPYL)PHTHALIMIDE, 95+%

2-(3-hydroxypropyl)isoindole-1,3-dione

<i>N</i>-(3-Hydroxypropyl)phthalimide

883-44-3

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