METHYL 4-BENZYLOXY-3-METHOXYBENZOATE

Product Name: METHYL 4-BENZYLOXY-3-METHOXYBENZOATE
CAS No.: 56441-97-5
Chemical Name: METHYL 4-BENZYLOXY-3-METHOXYBENZOATE
Synonyms: -3-methoxybenzoate;RARECHEM AL BF 0064;Methyl 4-(benzyloxy);METHYL BENZYL VANILLATE;METHYL 4-BENZYLOXY-3-METHOXYBENZOATE;Methyl 3-methoxy-4-(phenylmethoxy)benzoate;3-methoxy-4-benzyloxybenzoic acid methyl ester;4-Benzyloxy-3-Methoxybenzoic Acid Methyl Ester;Benzoic acid, 3-Methoxy-4-(phenylMethoxy)-, Methyl ester;3-?methoxy-?4-?(phenylmethoxy)?-?, methyl ester Benzoic acid
CBNumber: CB6774978
Molecular Formula: C16H16O4
Formula Weight: 272.3
MOL File: 56441-97-5.mol

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METHYL 4-BENZYLOXY-3-METHOXYBENZOATE Property

Boiling point:: 400.1±30.0 °C(Predicted)
Density: 1.153±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DCM, Ethyl Acetate
form: Solid
color: Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B286455
Product name: 4-Benzyloxy-3-methoxybenzoicAcidMethylEster
Packaging: 500mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-M0193
Product name: methyl4-(benzyloxy)-3-methoxybenzoate
Purity: 99.85%
Packaging: 25g
Price: $92
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0393155
Product name: METHYL-4-(BENZYLOXY)-3-METHOXYBENZOATE
Purity: 95.00%
Packaging: 5MG
Price: $495.33
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 54364
Product name: 4-Benzyloxy-3-methoxybenzoicAcidMethylEster
Packaging: 2.5g
Price: $650
Updated: 2021/12/16

AK Scientific

Product number: X6076
Product name: Methyl4-benzyloxy-3-methoxybenzoate
Packaging: 5g
Price: $47
Updated: 2021/12/16

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METHYL 4-BENZYLOXY-3-METHOXYBENZOATE Chemical Properties,Usage,Production

Uses

4-Benzyloxy-3-methoxybenzoic Acid Methyl Ester is an intermediate in the synthesis of Clomiphene (C587025), an synthetic estrogen agonist-antagonist.

Synthesis

3943-74-6

100-39-0

56441-97-5

General method 1: 4-chloroquinazoline derivatives were synthesized as target products by the introduction of alkyl amino side chains. Specifically, this includes the preparation of 4-chloro-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinazoline, 4-chloro-7-methoxy-6-[3-(4-methylpiperazin-1-yl)propoxy]quinazoline, and 4-chloro-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline. Step 1: Methyl vanillate or methyl isovanillate (7.29 g, 40 mmol) was dissolved in 25 mL of dimethylformamide, followed by the addition of potassium carbonate (8.29 g, 60 mmol) and benzyl bromide (5.26 mL, 44 mmol). The reaction mixture was heated to 100 °C and maintained at this temperature for 3 hours. After completion of the reaction, it was cooled to room temperature, diluted with water and the product was extracted several times with ethyl acetate. The organic phases were combined and washed sequentially with water and brine. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent to obtain methyl 4-benzyloxy-3-methoxybenzoate or methyl 3-benzyloxy-4-methoxybenzoate, and the product could be used for subsequent reaction without further purification.

References

[1] Patent: US2007/21446, 2007, A1. Location in patent: Page/Page column 14
[2] Patent: EP1785420, 2007, A1. Location in patent: Page/Page column 18
[3] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 18, p. 6728 - 6737
[4] Patent: EP1746096, 2007, A1. Location in patent: Page/Page column 23
[5] ChemMedChem, 2016, vol. 11, # 20, p. 2327 - 2338

METHYL 4-BENZYLOXY-3-METHOXYBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 4-BENZYLOXY-3-METHOXYBENZOATE Suppliers

China 85 Germany 1 India 1 Switzerland 2 United Kingdom 4 United States 7 Global 100

A.J Chemicals

Tel: --
Fax: --
Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

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View Lastest Price from METHYL 4-BENZYLOXY-3-METHOXYBENZOATE manufacturers

Yangzhou Qinyuan Pharmatech Co.,ltd

Product: METHYL 4-BENZYLOXY-3-METHOXYBENZOATE 56441-97-5
Price: US $10.00/g
Min. Order: 10g
Purity: 0.99
Supply Ability: 1ton
Release date: 2024-10-31

Honest Joy Holdings Limited

Product: Methyl 4-(benzyloxy)-3-methoxybenzoate 56441-97-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.4%
Supply Ability: 100 tons
Release date: 2022-01-17

Career Henan Chemical Co

Product: METHYL 4-BENZYLOXY-3-METHOXYBENZOATE 56441-97-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-08-15

56441-97-5, METHYL 4-BENZYLOXY-3-METHOXYBENZOATERelated Search:

Ethyl 4-(benzylaMino)butanoate hydrochloride METHYL 3,4,5-TRIS(BENZYLOXY)BENZOATE METHYL 7-METHOXY-2,2-DIPHENYL-1,3-BENZODIOXOLE-5-CARBOXYLATE METHYL 4-BENZYLOXY-3-METHOXYBENZOATE ETHYL 3,4-DIBENZYLOXYBENZOATE RARECHEM AL BI 0979 RARECHEM AL BF 1220 RARECHEM AL BF 0665 RARECHEM AL BI 1132 RARECHEM AL BI 1049 RARECHEM AL BF 1049 RARECHEM AL BI 1087 3,4,5-TRIBENZOYLOXYBENZOIC ACID N-PROPYL ESTER RARECHEM AL BF 1087 TOSLAB 12790 RARECHEM AL BI 0936 RARECHEM AL BF 1132 RARECHEM AL BF 0936

METHYL BENZYL VANILLATE

METHYL 4-BENZYLOXY-3-METHOXYBENZOATE

RARECHEM AL BF 0064

4-Benzyloxy-3-Methoxybenzoic Acid Methyl Ester

Benzoic acid, 3-Methoxy-4-(phenylMethoxy)-, Methyl ester

-3-methoxybenzoate

Methyl 4-(benzyloxy)

3-?methoxy-?4-?(phenylmethoxy)?-?, methyl ester Benzoic acid

Methyl 3-methoxy-4-(phenylmethoxy)benzoate

3-methoxy-4-benzyloxybenzoic acid methyl ester

56441-97-5

56411-97-5

Aromatic Esters