Difenidol hydrochloride

Product Name: Difenidol hydrochloride
CAS No.: 3254-89-5
Chemical Name: Difenidol hydrochloride
Synonyms: wansar;Ansmin;maniol;cefadol;tenesdol;SKF 478A;celmidol;mecalmin;pineroro;satanolon
CBNumber: CB6777267
Molecular Formula: C21H27NO
Formula Weight: 309.45
MOL File: 3254-89-5.mol

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Difenidol hydrochloride Property

Melting point:: 212-214°
storage temp.: 2-8°C
solubility: DMSO (Slightly, Sonicated), Methanol (Slightly)
form: Solid
color: White to Off-White
PH: pH (10g/l, 25℃) : 4.7～6.5
Water Solubility: H2O: 2mg/mL, clear (warmed)
Merck: 14,3311
InChI: InChI=1S/C21H27NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1-2,4-7,11-14,23H,3,8-10,15-18H2
InChIKey: OGAKLTJNUQRZJU-UHFFFAOYSA-N
SMILES: C(O)(CCCN1CCCCC1)(C1=CC=CC=C1)C1C=CC=CC=1
CAS DataBase Reference: 3254-89-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
WGK Germany: 3
RTECS: TM4970500
HS Code: 2933.39.9200
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral
Toxicity: LD50 oral in rat: 515mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2169
Product name: Diphenidol hydrochloride
Purity: ≥98% (HPLC)
Packaging: 100MG
Price: $53.86
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2169
Product name: Diphenidol hydrochloride
Purity: ≥98% (HPLC)
Packaging: 500MG
Price: $115
Updated: 2025/07/31

TCI Chemical

Product number: D2062
Product name: 1,1-Diphenyl-4-piperidino-1-butanol Hydrochloride
Purity: >99.0%(T)
Packaging: 25g
Price: $110
Updated: 2025/07/31

Cayman Chemical

Product number: 18674
Product name: Diphenidol (hydrochloride)
Purity: ≥98%
Packaging: 10g
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18674
Product name: Diphenidol (hydrochloride)
Purity: ≥98%
Packaging: 25g
Price: $92
Updated: 2024/03/01

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Difenidol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Diphenidol is an muscarinic antagonist is an antivertigo agent. Diphenidol displays heart arrhythmia inhibition and parasympatholytic activity.

Definition

ChEBI: Difenidol hydrochloride is a diarylmethane.

brand name

Vontrol (GlaxoSmithKline).

Biological Activity

Diphenidol is a non-selective muscarinic acetylcholine receptor antagonist. Diphenidol is an antiemetic agent used in the treatment of vomiting and vertigo.

Synthesis

Difenidol hydrochloride is synthesized in three steps. S1: Preparation of 1-(3-chloropropyl)hexahydropyridine: 1,3-Bromochloropropane reacts with hexahydropyridine at room temperature. Liquid base is then added. After layering, the oily layer is collected and dried to give the intermediate. S2: Preparation of ??,??-diphenyl-1-piperidinobutanol: After initiation with magnesium, a THF solution of intermediate N-(3-chloropropyl)piperidine is added dropwise, followed by a THF solution of benzophenone. After holding, the mixture is poured into ice-cold ammonium chloride solution for hydrolysis. Filtration and drying yield the product. S3: Preparation of ??,??-diphenyl-1-piperidinobutanol hydrochloride: The product from step 2 is dissolved in acetone. After decolorization, hydrochloric acid is added dropwise to form the salt. Gradient cooling induces crystallization. Filtration and drying give the final product.

Difenidol hydrochloride Preparation Products And Raw materials

Raw materials

Piperidine Benzophenone Bromoethane 1-Bromo-3-chloropropane

Preparation Products

Terfenadine

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Difenidol hydrochloride Suppliers

Americas 1 Canada 2 China 185 Europe 1 Germany 3 India 7 Italy 1 Japan 4 Mexico 1 South Korea 2 Spain 1 Switzerland 1 United Kingdom 8 United States 27 Venezuela 1 Global 245

Henan yu Chen pharmaceutical co., LTD

Tel: 0374-5699939 18864655557
Fax: +86-374-5699958
Email: yuchenchem@126.com
Country: China
ProdList: 30
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527621225
Email: 1791901229@qq.com
Country: China
ProdList: 6912
Advantage: 52

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

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View Lastest Price from Difenidol hydrochloride manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Difenidol hydrochloride 3254-89-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kgs
Release date: 2025-09-25

Henan Xiangtong Chemical Co., Ltd.

Product: Difenidol hydrochloride 3254-89-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 100T
Release date: 2019-11-01

Zhuozhou Wenxi import and Export Co., Ltd

Product: Difenidol hydrochloride 3254-89-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

3254-89-5, Difenidol hydrochlorideRelated Search:

Diphenyldiethoxysilane Topotecan hydrochloride Chlorodiphenylphosphine tert-Butylchlorodiphenylsilane 1-AdaMantanethylaMine Diphenylsilane Diphenylphosphine Difenidol Dichlorodiphenylsilane 1-Propylpiperidine 1-(3-bromopropyl)Piperidine 1,3-BIS(4-PIPERIDINYL)PROPANE MONOHYDRATE, 98 Diphenidol-d10 Piperidine,1,1'-(1,5-pentanediyl)bis- (+-) 1-BROMO-2-METHYLBUTANE 95 5-DIETHYLAMINO-2-PENTANOL (R)-(+)-1-PHENYL-1-BUTANOL (S)-(-)-1-PHENYL-1-BUTANOL

DIFENIDOL HYDROCHLORIDE

DIPHENIDOL

DIPHENIDOL HYDROCHLORIDE

LABOTEST-BB LT00771934

1,1-DIPHENYL-4-PIPERIDINO-1-BUTANOL HYDROCHLORIDE

1,1-diphenyl-4-(1-piperidyl)butan-1-ol hydrochloride

1-(4-HYDROXY-4,4-DIPHENYLBUTYL)PIPERIDINE HYDROCHLORIDE

alpha,alpha-diphenyl-1-piperidinebutanohydrochloride

tenesdol

wansar

TIMTEC-BB SBB006449

α,α-diphenyl-1-piperidinebutanol,hydrochloride (1:1)

SKF 478A

Diphenidol Hydrochloride 1-(4-Hydroxy-4,4-diphenylbutyl)piperidine Hydrochloride

1,1-Diphenyl-4-(piperidin-1-yl)butan-1-ol hydrochloride

alpha,alpha-diphenylpiperidine-1-butanol hydrochloride

DIPHENIDOL HCL

α,α-Diphenyl-1-piperidine butanol hydrochloride

1,1-diphenyl-4-piperidino-1-butanol

Difenidol hydrochloride (JP14)

1,1-DIPHENYL-4-PIPERIDINO-1-BUTANOL HYDROCHLORIDE 99+%

1,1-Diphenyl-4-piperidino-1-butanol, Difenidol

Ansmin

1,1-DIPHENYL-4-(PIPERIDIN-1-YL)BUTAN-1-OL HCL

alpha,alpha-diphenyl-1-piperidinebutanolhydrochloride

cefadol

celmidol

difenidolin

maniol

mecalmin

pineroro

satanolon

1,1-Diphenyl-4-piperidino-1-butanolHydrochloride&gt

Diphenyl Hydrochloride

Difenidol hydrochloride USP/EP/BP

Diphenidol HCl (Difenidol)

1,1-Diphenyl-4-piperidino-1-butanol Hydrochloride（Diphenidol Hydrochloride）

high purity Difenidol hydrochloride 90%

Diphenidol hydrochloride, 10 mM in DMSO

Diphenidol hydrochloride - Bio-X ?

3254-89-5

C21H28NOCl

C21H27NOHCl

Piperidines

Building Blocks

Heterocyclic Building Blocks