Methyl 1,2,4-triazole-3-carboxylate
Uses- Product Name
- Methyl 1,2,4-triazole-3-carboxylate
- CAS No.
- 4928-88-5
- Chemical Name
- Methyl 1,2,4-triazole-3-carboxylate
- Synonyms
- METHYL 1H-1,2,4-TRIAZOLE-3-CARBOXYLATE;Methyl 4H-1,2,4-triazole-3-carboxylate;Methyl 1H-1;-1H-1,2,4-triazoL;Ribavirin API Impurity J;4-triazole-3-carboxylate;Methyl triazole carboxylate;1,2,4-Triazole-3-carboxylatem;Methyl triazole-3-carboxylate;1,2,4-Triazole-3-methyl-carbox
- CBNumber
- CB6779786
- Molecular Formula
- C4H5N3O2
- Formula Weight
- 127.1
- MOL File
- 4928-88-5.mol
Methyl 1,2,4-triazole-3-carboxylate Property
- Melting point:
- 196-199 °C(lit.)
- Boiling point:
- 283.9±23.0 °C(Predicted)
- Density
- 1.380±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 7.96±0.20(Predicted)
- form
- Liquid
- color
- Clear colorless to yellow
- InChI
- InChI=1S/C4H5N3O2/c1-9-4(8)3-5-2-6-7-3/h2H,1H3,(H,5,6,7)
- InChIKey
- QMPFMODFBNEYJH-UHFFFAOYSA-N
- SMILES
- N1C(C(OC)=O)=NC=N1
- CAS DataBase Reference
- 4928-88-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 530352
- Product name
- Methyl-1H-1,2,4-triazole-3-carboxylate
- Purity
- 98%
- Packaging
- 25g
- Price
- $28.61
- Updated
- 2025/07/31
- Product number
- M2368
- Product name
- Methyl 1,2,4-Triazole-3-carboxylate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $32
- Updated
- 2025/07/31
- Product number
- M2368
- Product name
- Methyl 1,2,4-Triazole-3-carboxylate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $88
- Updated
- 2025/07/31
- Product number
- M331155
- Product name
- Methyl 1,2,4-Triazole-3-carboxylate
- Packaging
- 100g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 4H58-1-000
- Product name
- Methyl 4H-1,2,4-triazole-3-carboxylate
- Packaging
- 25g
- Price
- $208
- Updated
- 2021/12/16
Methyl 1,2,4-triazole-3-carboxylate Chemical Properties,Usage,Production
Uses
Methyl 1,2,4-Triazole-3-carboxylate has been used as a reactant for the preparation of Ribavirin (1-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide, an antiviral agent.
Chemical Properties
White solid
Uses
Methyl 1,2,4-Triazole-3-carboxylate has been used as a reactant for the preparation of Ribavirin (1-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide, an antiviral agent.
Uses
Methyl-1H-1,2,4-triazole-3-carboxylate (1,2,4-Triazole-3-methylcarboxylate) may be used in the preparation of 1H-1,2,4-triazole-3-carbohydrazide.
It may also be used in the synthesis of the following nucleoside analogues:
- 1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta-[1,3]dioxol-4-yl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester
- methyl 4,6-O-benzylidene-2-(methyl 1H-1,2,4-triazol-1-yl-3-carboxylate)-2-deoxy-<SC>D</SC>-altrohexopyranoside
- 1,5-anhydro-4,6-O-benzylidene-2-(methyl 1H-1,2,4-triazol-1-yl-3-carboxylate)-2-deoxy-<SC>D</SC>-altro-hexitol
Application
Methyl 1,2,4-triazole-3-carboxylate is an essential raw material for the synthesis of antiviral drug ribavirin, and ribavirin is a broad-spectrum antiviral drug that is effective against a variety of viruses Has an inhibitory effect. Ribavirin is widely used and the market demand is huge, so the demand for methyl 1,2,4-triazole-3-carboxylate is also huge.
General Description
Methyl-1H-1,2,4-triazole-3-carboxylate can be synthesized from 5-amino-1,2,4-triazole-3-carboxylic acid via esterification with methanol. It is utilized as precursor for preparing the nucleoside analogue, Ribavirin. The crystal structure of methyl-1H-1,2,4-triazole-3-carboxylate has been analyzed.
Synthesis
The product Methyl 1,2,4-triazole-3-carboxylate is synthesized using lime nitrogen as the raw material, and hydrazinolysis, condensation, esterification, deamination and other steps are performed to obtain the product Methyl 1,2,4-triazole-3-carboxylate. The synthesis route using lime nitrogen as the starting material: lime nitrogen first reacts with hydrazine hydrate to obtain a nitrile addition product, and then condenses with oxalic acid to obtain 1,2,4-triazole-3-carboxylic acid methyl ester-5-amino. The deamination process generally requires diazotization and then nitrogen release in an alcohol solution to obtain the product Methyl 1,2,4-triazole-3-carboxylate in which the amino group is replaced by hydrogen.
Synthesis of ethyl cyanoformate: Using ethyl cyanoformate as the raw material, it is subjected to addition with formic acid hydrazide and then cyclization to obtain ethyl 1,2,4-triazole-3-carboxylate, and then alcoholysis with methanol to obtain methyl 1,2,4-triazole-3-carboxylate. Ethyl cyanoformate is used as a raw material and reacted with ethanol to obtain ethoxyamidine hydrochloride, which is then reacted with formic hydrazide for addition reaction, and then cyclized under high temperature conditions to obtain 1,2,4-triazole-3-carboxylic acid ethyl ester, and then ester exchange with methanol is carried out to obtain the final product.
Methyl 1,2,4-triazole-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 1,2,4-triazole-3-carboxylate manufacturers
- Product
- Methyl 1,2,4-triazole-3-carboxylate 4928-88-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-28
- Product
- Methyl 1,2,4-triazole-3-carboxylate 4928-88-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
- Product
- Methyl 1,2,4-Triazole-3-carboxylate 4928-88-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 5 tons
- Release date
- 2024-12-06