Methyl 1,2,4-triazole-3-carboxylate

Uses

Product Name: Methyl 1,2,4-triazole-3-carboxylate
CAS No.: 4928-88-5
Chemical Name: Methyl 1,2,4-triazole-3-carboxylate
Synonyms: METHYL 1H-1,2,4-TRIAZOLE-3-CARBOXYLATE;Methyl 4H-1,2,4-triazole-3-carboxylate;Methyl 1H-1;-1H-1,2,4-triazoL;Ribavirin API Impurity J;4-triazole-3-carboxylate;Methyl triazole carboxylate;1,2,4-Triazole-3-carboxylatem;Methyl triazole-3-carboxylate;1,2,4-Triazole-3-methyl-carbox
CBNumber: CB6779786
Molecular Formula: C4H5N3O2
Formula Weight: 127.1
MOL File: 4928-88-5.mol

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Methyl 1,2,4-triazole-3-carboxylate Property

Melting point:: 196-199 °C(lit.)
Boiling point:: 283.9±23.0 °C(Predicted)
Density: 1.380±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 7.96±0.20(Predicted)
form: Liquid
color: Clear colorless to yellow
InChI: InChI=1S/C4H5N3O2/c1-9-4(8)3-5-2-6-7-3/h2H,1H3,(H,5,6,7)
InChIKey: QMPFMODFBNEYJH-UHFFFAOYSA-N
SMILES: N1C(C(OC)=O)=NC=N1
CAS DataBase Reference: 4928-88-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 530352
Product name: Methyl-1H-1,2,4-triazole-3-carboxylate
Purity: 98%
Packaging: 25g
Price: $28.61
Updated: 2025/07/31

TCI Chemical

Product number: M2368
Product name: Methyl 1,2,4-Triazole-3-carboxylate
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: M2368
Product name: Methyl 1,2,4-Triazole-3-carboxylate
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $88
Updated: 2025/07/31

TRC

Product number: M331155
Product name: Methyl 1,2,4-Triazole-3-carboxylate
Packaging: 100g
Price: $200
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-000
Product name: Methyl 4H-1,2,4-triazole-3-carboxylate
Packaging: 25g
Price: $208
Updated: 2021/12/16

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Methyl 1,2,4-triazole-3-carboxylate Chemical Properties,Usage,Production

Uses

Methyl 1,2,4-Triazole-3-carboxylate has been used as a reactant for the preparation of Ribavirin (1-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide, an antiviral agent.

Chemical Properties

White solid

Uses

Methyl 1,2,4-Triazole-3-carboxylate has been used as a reactant for the preparation of Ribavirin (1-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide, an antiviral agent.

Uses

Methyl-1H-1,2,4-triazole-3-carboxylate (1,2,4-Triazole-3-methylcarboxylate) may be used in the preparation of 1H-1,2,4-triazole-3-carbohydrazide.
It may also be used in the synthesis of the following nucleoside analogues:

1-(2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta-[1,3]dioxol-4-yl)-1H-1,2,4-triazole-3-carboxylic acid methyl ester
methyl 4,6-O-benzylidene-2-(methyl 1H-1,2,4-triazol-1-yl-3-carboxylate)-2-deoxy-<SC>D</SC>-altrohexopyranoside
1,5-anhydro-4,6-O-benzylidene-2-(methyl 1H-1,2,4-triazol-1-yl-3-carboxylate)-2-deoxy-<SC>D</SC>-altro-hexitol

Application

Methyl 1,2,4-triazole-3-carboxylate is an essential raw material for the synthesis of antiviral drug ribavirin, and ribavirin is a broad-spectrum antiviral drug that is effective against a variety of viruses Has an inhibitory effect. Ribavirin is widely used and the market demand is huge, so the demand for methyl 1,2,4-triazole-3-carboxylate is also huge.

General Description

Methyl-1H-1,2,4-triazole-3-carboxylate can be synthesized from 5-amino-1,2,4-triazole-3-carboxylic acid via esterification with methanol. It is utilized as precursor for preparing the nucleoside analogue, Ribavirin. The crystal structure of methyl-1H-1,2,4-triazole-3-carboxylate has been analyzed.

Synthesis

The product Methyl 1,2,4-triazole-3-carboxylate is synthesized using lime nitrogen as the raw material, and hydrazinolysis, condensation, esterification, deamination and other steps are performed to obtain the product Methyl 1,2,4-triazole-3-carboxylate. The synthesis route using lime nitrogen as the starting material: lime nitrogen first reacts with hydrazine hydrate to obtain a nitrile addition product, and then condenses with oxalic acid to obtain 1,2,4-triazole-3-carboxylic acid methyl ester-5-amino. The deamination process generally requires diazotization and then nitrogen release in an alcohol solution to obtain the product Methyl 1,2,4-triazole-3-carboxylate in which the amino group is replaced by hydrogen.
Synthesis of ethyl cyanoformate: Using ethyl cyanoformate as the raw material, it is subjected to addition with formic acid hydrazide and then cyclization to obtain ethyl 1,2,4-triazole-3-carboxylate, and then alcoholysis with methanol to obtain methyl 1,2,4-triazole-3-carboxylate. Ethyl cyanoformate is used as a raw material and reacted with ethanol to obtain ethoxyamidine hydrochloride, which is then reacted with formic hydrazide for addition reaction, and then cyclized under high temperature conditions to obtain 1,2,4-triazole-3-carboxylic acid ethyl ester, and then ester exchange with methanol is carried out to obtain the final product.

Methyl 1,2,4-triazole-3-carboxylate Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from Methyl 1,2,4-triazole-3-carboxylate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Methyl 1,2,4-triazole-3-carboxylate 4928-88-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Henan Aochuang Chemical Co.,Ltd.

Product: Methyl 1,2,4-triazole-3-carboxylate 4928-88-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Shanghai Yongzeng Technology Co.,Ltd

Product: Methyl 1,2,4-Triazole-3-carboxylate 4928-88-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 5 tons
Release date: 2024-12-06

4928-88-5, Methyl 1,2,4-triazole-3-carboxylate Related Search:

Kresoxim-methyl Methylparaben RESMETHRIN Methyl acrylate 5-Methyl-1H-benzotriazole 1H-Benzotriazole Bensulfuron methyl Tolyltriazole 1,2,4-Triazole Thiophanate-methyl Methyl ethyl 5-amino-2H-1,2,4-triazole-3-carboxylate Parathion-methyl Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate FENCHLORAZOL-ETHYL Methyl bromide Methyl-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxylate 1H-1,2,4-Triazole-3-carboxylic acid

1,2,4-Triazole-3-carboxylatem

1,2,4-triazole-3-carboxylicacidmethylester

Methyl-1H-1,2,4-triazole-3-carboxylate 98%

methyl 1H-1,2,4-triazole-3-carboxylate, 1H-[1,2,4]triazole-3-carboxylic acid methyl ester, methyl 1,2,4-triazole-3-carboxylate, 1,2,4-triazolecarboxylic acid methyl ester, methyl 1,2,4-1H-triazole-3-carboxylate, methyl-1H-1,2,4-triazole-3-carboxylate, methyl-1,2,4-triazole-3-carboxylate

Methyl 4H-1,2,4-triazole-3-carboxylate

Methyle1, 2, 4-triazole-3-carboxylate

1H-1,2,4-triazole-3-carboxylate

1,2,4-triazol-3-carboxylic acid methyl ester / ribavirin intermediate

1,2,4-triazol-3-carboxylic acid methyl ester

1,2,4-Triazole-3-Carboxylic Acid Methyleste

Ribavirin API Impurity J

METHYL 1H-TRIAZOLE-3-CARBOXYLATE

METHYL 1H-1,2,4-TRIAZOLE-3-CARBOXYLATE

METHYL 1,2,4-TRIAZOLE-3-CARBOXYLATE

1H-TRIAZOLE-3-CARBOXYLIC ACID METHYL ESTER

1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID METHYL ESTER

1,2,4-Triatoze-3-carboxylic acid Methylester

1,2,4-Triazole-3-methyl carboxylate

1.2.4-triazole-3-methyl-carboxylata

1H-1,2,4-Triazole-3-methylcarboxylate

1,2,4-Triazole-3-CarboxylataAcidMethylEster

1,2,4-TRIAZOLE-3-METHYL CARBOXYLATE (RIBAMETHYLBASE)

1H-1,2,4-Triazole-5-carboxylic acid, methyl ester

3-Methoxycarbonyl-1,2,4-triazole

1H-1,2,4-TRIAZOLE-3-CARBOXYLATE, METHYL ESTER

1H-1,2,4-TRIAZOLE-3-CARBOXYLATE, METHYL ESTERRIBAVIRIN

1,2,4-Triazole-3-methyl-carbox

Methyl 1,2,4-triazole-3-carboxylate,95%

4-triazole-3-carboxylate

Methyl 1H-1

1-Methyl-1H-1,2,4-triazole-3-carboxylate

Methyl1,2,4-Triazole-3-carboxylate&gt

-1H-1,2,4-triazoL

Methyl triazole carboxylate

Natural 1,2,4-Triazole-3-Carboxylatem

Methyl triazole-3-carboxylate

Methyl 1H-1,2,4-triazole-5-carboxylate

MethyI 1,2 ,4-triazole-3- carboxylate

Triazole carboxylic acid methyl ester

Methyl-1<i>H</i>-1,2,4-triazole-3-carboxylate

4928-88-5

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