GITOXIGENIN Property

Melting point:

~230 °C

Boiling point:

435.71°C (rough estimate)

Density 

1.0639 (rough estimate)

refractive index 

1.6120 (estimate)

storage temp. 

−20°C

pka

14.56±0.70(Predicted)

Merck 

13,4445

Safety

Hazard Codes 

T

Risk Statements 

23/24/25

Safety Statements 

36/37/39-45

RIDADR 

UN 1544 6.1/PG 1

WGK Germany 

3

RTECS 

FH5391000

F 

10

HazardClass 

6.1(b)

PackingGroup 

III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P311Call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

GITOXIGENIN Chemical Properties,Usage,Production

Chemical Properties

light yellow flakes

Uses

Gitoxigenin is a related compound of Digitoxigenin, which has been used in a study to assess its stereochemical effects in cancer cytotoxicity. Digitoxigenin has also been used in a study to investigate the advantage of gold(I)-catalyzed glycosidation of glycosyl o-alkyl benzoates to assemble digitoxin.

Definition

ChEBI: Gitoxigenin is a 3beta-hydroxy steroid, a 14beta-hydroxy steroid and a 16beta-hydroxy steroid. It derives from a hydride of a 5beta-cardanolide.

Biochem/physiol Actions

Structure-activity relationships for 16β-substituted digitoxigenins as inhibitors of Na+/K+ ATPases.

Purification Methods

Recrystallisation of gitoxigenin from aqueous EtOH produces plates of the sesquihydrate which dehydrate on drying at 100o in vacuo. It also recrystallises from Me2CO/MeOH and from EtOAc (the crystals contain 1 mol of EtOAc) with [] D +24.8o (c 1, dioxane). It has UV with max at 310, 485 and 520nm in 96% H2SO4. On heating with ethanolic HCl it yields digitaligenin with loss of H2O. [Smith J Chem Soc 23 1931, Beilstein 8 IV 2456.]