TEZOSENTAN

Product Name: TEZOSENTAN
CAS No.: 180384-57-0
Chemical Name: TEZOSENTAN
Synonyms: RO 610612;TEZOSENTAN;N-(2-(2-(2H-Tetrazol-5-yl)pyridin-4-yl)-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl;N-(2-(2-(2H-Tetrazol-5-yl)pyridin-4-yl)-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5;N-(2-(2-(2H-Tetrazol-5-yl)pyridin-4-yl)-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-isopropylpyridine-2-sulfonamide;N-[6-(2-Hydroxyethoxy)-5-(2-Methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)-4-pyridinyl]-4-pyriMidinyl]-5-(1-Methylethyl)-2-pyridinesulfonaMide;2-Pyridinesulfonamide, N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)-4-pyridinyl]-4-pyrimidinyl]-5-(1-methylethyl)-
CBNumber: CB6790143
Molecular Formula: C27H27N9O6S
Formula Weight: 605.62
MOL File: 180384-57-0.mol

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TEZOSENTAN Property

Melting point:: 198-200°
Boiling point:: 761.2±70.0 °C(Predicted)
Density: 1.432±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO
pka: 2.93±0.10(Predicted)
form: Solid
color: Off-white to gray

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: T321500
Product name: Tezosentan
Packaging: 100mg
Price: $14025
Updated: 2021/12/16

Matrix Scientific

Product number: 099433
Product name: N-(2-(2-(2H-Tetrazol-5-yl)pyridin-4-yl)-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-isopropylpyridine-2-sulfonamide
Purity: 95+%
Packaging: 1g
Price: $4725
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008885
Product name: TEZOSENTAN
Purity: 95.00%
Packaging: 25MG
Price: $8373.75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008885
Product name: TEZOSENTAN
Purity: 95.00%
Packaging: 50MG
Price: $10106.25
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 62074
Product name: Tezosentan
Packaging: 100mg
Price: $13750
Updated: 2021/12/16

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TEZOSENTAN Chemical Properties,Usage,Production

Uses

A potent dual endothelian (ETA/ETB) receptor antagonist optimized from Bosentan (B675900). It is used in the treatment of congestive heart failure.

Uses

A potent dual endothelian (ETA/ETB) receptor antagonist optimized from Bosentan (B675900). Tezosentan is used in the treatment of congestive heart failure.

in vivo

In pithed Wistar rats, Tezosentan dose-dependently inhibits the pressor effect of big ET-1 (P<0.001 at all doses). At the lowest dose tested of 1 mg/kg, Tezosentan inhibits the pressor effect of the various doses of big ET-1 by 50 to 80%. Tezosentan has no effect by itself on blood pressure in these pithed rats. Tezosentan is very effective in a rat model of acute renal failure. ET antagonists have been shown to prevent the vasoconstriction and the renal failure that follow acute renal ischemia in rats^[1].

IC 50

ET_A: 9.5 (pA2); ET_B: 7.7 (pA2)

TEZOSENTAN Preparation Products And Raw materials

Raw materials

Preparation Products

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TEZOSENTAN Suppliers

Canada 1 China 24 India 2 United States 9 Global 36

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
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Advantage: 65

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Shanghai Han-Xiang Chemical Co., Ltd.

Tel: 15971444841
Fax: 18327183813
Email: amber@biochempartner.com
Country: China
ProdList: 3061
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

180384-57-0, TEZOSENTANRelated Search:

5-METHYLPYRIDINE-2-SULFONAMIDE 2-(4-PYRIDYL)-4-AMINO-6-HYDROXY PYRIMIDINE 5,6-Dimethoxypyrimidin-4-ylamine 4-AMINO-6-HYDROXY-2-METHYLPYRIMIDINE DIHYDRATE 4-(2H-TETRAZOL-5-YL)-PYRIDINE 4-AMINO-6-HYDROXY-2-METHYLPYRIMIDINE 2-Pyridinesulfonamide(6CI,7CI,9CI) TEZOSENTAN

TEZOSENTAN

N-[6-(2-Hydroxyethoxy)-5-(2-Methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)-4-pyridinyl]-4-pyriMidinyl]-5-(1-Methylethyl)-2-pyridinesulfonaMide

N-(2-(2-(2H-Tetrazol-5-yl)pyridin-4-yl)-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5

N-(2-(2-(2H-Tetrazol-5-yl)pyridin-4-yl)-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl

N-(2-(2-(2H-Tetrazol-5-yl)pyridin-4-yl)-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-isopropylpyridine-2-sulfonamide

RO 610612

2-Pyridinesulfonamide, N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)-4-pyridinyl]-4-pyrimidinyl]-5-(1-methylethyl)-

180384-57-0

C27H27N9O6S

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds