2-Pyridinesulfonamide(6CI,7CI,9CI)
- Product Name
- 2-Pyridinesulfonamide(6CI,7CI,9CI)
- CAS No.
- 63636-89-5
- Chemical Name
- 2-Pyridinesulfonamide(6CI,7CI,9CI)
- Synonyms
- pyridine-2-sulfonamide;Pyridine -2-suflonly aMide;pyridine-2-sulfonic acid amide;2-Pyridinesulfonamide(6CI,7CI,9CI)
- CBNumber
- CB41289189
- Molecular Formula
- C5H6N2O2S
- Formula Weight
- 158.18
- MOL File
- 63636-89-5.mol
2-Pyridinesulfonamide(6CI,7CI,9CI) Property
- Melting point:
- 140-141 °C(Solv: ethanol (64-17-5); water (7732-18-5))
- Boiling point:
- 357.7±34.0 °C(Predicted)
- Density
- 1.417±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 9.21±0.60(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C5H6N2O2S/c6-10(8,9)5-3-1-2-4-7-5/h1-4H,(H2,6,8,9)
- InChIKey
- DWJMBQYORXLGAE-UHFFFAOYSA-N
- SMILES
- C1(S(N)(=O)=O)=NC=CC=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B525670
- Product name
- Pyridine-2-sulfonamide
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B525670
- Product name
- Pyridine-2-sulfonamide
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B525670
- Product name
- Pyridine-2-sulfonamide
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 068430
- Product name
- 2-Pyridinesulfonamide
- Purity
- >95%
- Packaging
- 250mg
- Price
- $87
- Updated
- 2021/12/16
- Product number
- 068430
- Product name
- 2-Pyridinesulfonamide
- Purity
- >95%
- Packaging
- 500mg
- Price
- $123
- Updated
- 2021/12/16
2-Pyridinesulfonamide(6CI,7CI,9CI) Chemical Properties,Usage,Production
Synthesis
2637-34-5
63636-89-5
General procedure for the synthesis of pyridine-2-sulfonamide from 2-pyridinethione: To a 1000 mL round-bottomed flask was added dichloromethane (200 mL) and 1 M aqueous hydrochloric acid solution (200 mL, 200 mmol, 5.0 equiv.), and the suspension was cooled to -5 to -10 °C using an ice-salt bath. To the well-stirred suspension was added 2-mercaptopyridine (4.45 g, 40 mmol), and the resulting yellow mixture was stirred for 10 minutes, followed by the dropwise addition of 6% sodium hypochlorite solution (208 mL, 132 mmol, 3.3 eq.) over 5 minutes. After the dropwise addition, the mixture was continued to be stirred at the same temperature for 10 min and subsequently transferred to a separatory funnel for separation. The separated organic layer was immediately added dropwise to a pre-cooled and stirred mixture of saturated ammonia methanol solution (80 mL) and dichloromethane (80 mL) at 0 °C. The aqueous layer in the partition funnel was washed twice with dichloromethane, and the organic layer was combined and added dropwise to the ammonia solution. The resulting white suspension was slowly warmed to room temperature and stirred for 2 hours. Subsequently, the solvent was removed by evaporation to give a white solid. The solid was dissolved in hot ethyl acetate (250 mL x 2) and filtered through filter paper to remove ammonium chloride. The filtrate was evaporated to give the crude product, which was finally purified by recrystallization from ethyl acetate and hexane to give pure pyridine-2-sulfonamide (4.15 g, 70% yield). The product was characterized by 1H NMR (500 MHz, DMSO-d6) and 13C NMR (125 MHz, DMSO-d6) and the data were consistent with the expected structure.
References
[1] Angewandte Chemie - International Edition, 2008, vol. 47, # 47, p. 9125 - 9129
[2] Synlett, 2018, vol. 29, # 9, p. 1232 - 1238
[3] Patent: WO2016/131098, 2016, A1. Location in patent: Page/Page column 122; 123
[4] Acta Poloniae Pharmaceutica, 1955, vol. 12, p. 5,8
[5] Chem.Abstr., 1957, p. 17911
2-Pyridinesulfonamide(6CI,7CI,9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
2-Pyridinesulfonamide(6CI,7CI,9CI) Suppliers
- Tel
- 021-60546673 13701861782
- Fax
- QQ:670259431
- kuanga111@sina.com
- Country
- China
- ProdList
- 934
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- sales@jonln.com
- Country
- China
- ProdList
- 1995
- Advantage
- 65
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18729
- Advantage
- 57
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- +86-25-68710855, +86-25-68710897
- Fax
- 025-68710856
- sales@springpharma.net
- Country
- China
- ProdList
- 1261
- Advantage
- 62
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
View Lastest Price from 2-Pyridinesulfonamide(6CI,7CI,9CI) manufacturers
- Product
- 2-Pyridinesulfonamide(6CI,7CI,9CI) 63636-89-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-07-11