PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE

Product Name: PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE
CAS No.: 4664-08-8
Chemical Name: PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE
Synonyms: FURO[3,4-C]PYRIDINE-1,3-DIONE;3,4-PYRIDINEDICARBOXYLIC ANHYDRIDE;CINCHOMERONIC ANHYDRIDE;PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE;1H,3H-furo[3,4-c]pyridine-1,3-dione;3,4-Pyridinecarboxylic acid anhydride;3,4-Pyridinecarboxylic anhydride, 97%;3,4-Pyridinedicarboxylic anhydride 97%;3,4-PYRIDINEDICARBOXYLIC ACID ANHYDRIDE;3,4-Pyridinedicarboxylic anhydride ,97%
CBNumber: CB9671924
Molecular Formula: C7H3NO3
Formula Weight: 149.1
MOL File: 4664-08-8.mol

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PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE Property

Melting point:: 75-77 °C (lit.)
Boiling point:: 139-142 °C(Press: 12 Torr)
Density: 1.556±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: -0.38±0.20(Predicted)
form: solid
color: White to off-white
Water Solubility: Decomposes in water.
Sensitive: Moisture Sensitive
InChI: InChI=1S/C7H3NO3/c9-6-4-1-2-8-3-5(4)7(10)11-6/h1-3H
InChIKey: KFKMGUPDWTWQFM-UHFFFAOYSA-N
SMILES: C1=NC=CC2C(=O)OC(=O)C1=2
CAS DataBase Reference: 4664-08-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 282715
Product name: 3,4-Pyridinedicarboxylic anhydride
Purity: 97%
Packaging: 1g
Price: $55.5
Updated: 2023/01/07

Sigma-Aldrich

Product number: 282715
Product name: 3,4-Pyridinedicarboxylic anhydride
Purity: 97%
Packaging: 5g
Price: $178
Updated: 2023/01/07

TCI Chemical

Product number: P3035
Product name: Furo[3,4-c]pyridine-1,3-dione
Purity: min. 95.0 %
Packaging: 1G
Price: $45
Updated: 2025/07/31

TCI Chemical

Product number: P3035
Product name: Furo[3,4-c]pyridine-1,3-dione
Purity: min. 95.0 %
Packaging: 5G
Price: $135
Updated: 2025/07/31

TRC

Product number: P991905
Product name: 3,4-Pyridinedicarboxylic anhydride
Packaging: 1g
Price: $50
Updated: 2021/12/16

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PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE Chemical Properties,Usage,Production

Chemical Properties

White to light yellow solid

Uses

Pyridine-3,4-dicarboxylic anhydride is an important organic intermediate. It is used in agrochemical, pharmaceutical and dyestuff field.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 37, p. 828, 1994 DOI: 10.1021/jm00032a018
The Journal of Organic Chemistry, 14, p. 97, 1949 DOI: 10.1021/jo01153a015

Synthesis

490-11-9

4664-08-8

The general procedure for the synthesis of pyridine-3,4-dicarboxylic anhydride from 3,4-pyridinedicarboxylic acid is as follows: in a 1 L round-bottomed flask fitted with a drying tube, 3,4-pyridinedicarboxylic acid (160 g, 1 mol) and acetic anhydride (500 mL) were added. The reaction mixture was refluxed in an oil bath at 165°C for 2 hours. Upon completion of the reaction, decompression concentration was carried out to remove excess acetic anhydride. After cooling, a residual oily substance was obtained. Methyl tert-butyl ether (500 mL) was added to the residue and stirred overnight at room temperature. Subsequently, a dark brown solid precipitate precipitated and was separated by filtration. The filter cake was washed with 100 mL of methyl tert-butyl ether (MTBE) and dried under vacuum at 45°C to give 99 g of solid product in 76% yield.

References

[1] Journal of Organic Chemistry, 1992, vol. 57, # 22, p. 5891 - 5899
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 6, p. 828 - 837
[3] Patent: EP503537, 1992, A1
[4] Patent: CN104557704, 2017, B. Location in patent: Paragraph 0042; 0043; 0044
[5] Monatshefte fuer Chemie, 1890, vol. 11, p. 144

PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE Preparation Products And Raw materials

Raw materials

Acetic anhydride 3,4-Pyridinedicarboxylic acid

Preparation Products

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PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE Suppliers

Belgium 1 China 124 Germany 2 India 3 Switzerland 1 The Netherlands 1 United Kingdom 9 United States 24 Global 165

Guangdong wengjiang Chemical Reagent Co., Ltd.

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Nanjing Habo Medical Technology Co., Ltd.

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JinYan Chemicals(ShangHai) Co.,Ltd.

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View Lastest Price from PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Pyridine-3,4-Dicarboxylic Anhydride 4664-08-8
Price: US $1.00-22.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000KG
Release date: 2024-07-31

Career Henan Chemical Co

Product: PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE 4664-08-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-07-11

4664-08-8, PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDERelated Search:

Dimethyl 2,6-Pyridinedicarboxylate 3,5-DIHYDROXYPYRIDINE Dimethyl 2,4-pyridinedicarboxylate 2,4-Pyridinedicarboxylic acid, 2-Methyl ester 2-Pyridinemethanethiol 2,4-PYRIDINECARBOXYLIC ACID, 4-METHYL ESTER 2,4-Pyridinedicarboxylic acid Pyridine hydrochloride 2,6-Pyridinedicarbonitrile 4-Pyridinesulfonamide(6CI,9CI) 2,3,5,6-Tetraaminopyridine trihydrochloride Pyridine trifluoroacetate PYRIDINE-2-THIOAMIDE 2-Pyridinesulfonamide(6CI,7CI,9CI) dimethyl pyridine-3,5-dicarboxylate METHYL ISONICOTINATE Pyridine-N-oxide 2-Pyridinecarbaldehyde oxime

CINCHOMERONIC ANHYDRIDE

FURO[3,4-C]PYRIDINE-1,3-DIONE

PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE

1,3-DIHYDROFURO[3,4-C]PYRIDINE-1,3-DIONE

3,4-PYRIDINEDICARBOXYLIC ACID ANHYDRIDE

3,4-PYRIDINEDICARBOXYLIC ANHYDRIDE

3,4-Pyridinecarboxylic acid anhydride

Pyridine-3,4-dicarboxylic anhydride ,97%

3,4-Pyridinedicarboxylic anhydride ,97%

3,4-Pyridinedicarboxylic anhydride 97%

3,4-Pyridinecarboxylic anhydride, 97%

Pyridine-3,4-dicarboxylic acid anhydride

1H,3H-furo[3,4-c]pyridine-1,3-dione

Furo[3,4-c]pyridine-1,3-dione, 1,3-Dioxofuro[3,4-c]pyridine

4664-08-8

Pyridines