ChemicalBook > CAS DataBase List > PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE

PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE

Product Name
PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE
CAS No.
4664-08-8
Chemical Name
PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE
Synonyms
FURO[3,4-C]PYRIDINE-1,3-DIONE;3,4-PYRIDINEDICARBOXYLIC ANHYDRIDE;CINCHOMERONIC ANHYDRIDE;PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE;1H,3H-furo[3,4-c]pyridine-1,3-dione;3,4-Pyridinecarboxylic acid anhydride;3,4-Pyridinecarboxylic anhydride, 97%;3,4-Pyridinedicarboxylic anhydride 97%;3,4-PYRIDINEDICARBOXYLIC ACID ANHYDRIDE;3,4-Pyridinedicarboxylic anhydride ,97%
CBNumber
CB9671924
Molecular Formula
C7H3NO3
Formula Weight
149.1
MOL File
4664-08-8.mol
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PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE Property

Melting point:
75-77 °C (lit.)
Boiling point:
139-142 °C(Press: 12 Torr)
Density 
1.556±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
-0.38±0.20(Predicted)
form 
solid
color 
White to off-white
Water Solubility 
Decomposes in water.
Sensitive 
Moisture Sensitive
InChI
InChI=1S/C7H3NO3/c9-6-4-1-2-8-3-5(4)7(10)11-6/h1-3H
InChIKey
KFKMGUPDWTWQFM-UHFFFAOYSA-N
SMILES
C1=NC=CC2C(=O)OC(=O)C1=2
CAS DataBase Reference
4664-08-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
282715
Product name
3,4-Pyridinedicarboxylic anhydride
Purity
97%
Packaging
1g
Price
$55.5
Updated
2023/01/07
Sigma-Aldrich
Product number
282715
Product name
3,4-Pyridinedicarboxylic anhydride
Purity
97%
Packaging
5g
Price
$178
Updated
2023/01/07
TCI Chemical
Product number
P3035
Product name
Furo[3,4-c]pyridine-1,3-dione
Purity
min. 95.0 %
Packaging
1G
Price
$45
Updated
2025/07/31
TCI Chemical
Product number
P3035
Product name
Furo[3,4-c]pyridine-1,3-dione
Purity
min. 95.0 %
Packaging
5G
Price
$135
Updated
2025/07/31
TRC
Product number
P991905
Product name
3,4-Pyridinedicarboxylic anhydride
Packaging
1g
Price
$50
Updated
2021/12/16
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PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE Chemical Properties,Usage,Production

Chemical Properties

White to light yellow solid

Uses

Pyridine-3,4-dicarboxylic anhydride is an important organic intermediate. It is used in agrochemical, pharmaceutical and dyestuff field.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 37, p. 828, 1994 DOI: 10.1021/jm00032a018
The Journal of Organic Chemistry, 14, p. 97, 1949 DOI: 10.1021/jo01153a015

Synthesis

490-11-9

4664-08-8

The general procedure for the synthesis of pyridine-3,4-dicarboxylic anhydride from 3,4-pyridinedicarboxylic acid is as follows: in a 1 L round-bottomed flask fitted with a drying tube, 3,4-pyridinedicarboxylic acid (160 g, 1 mol) and acetic anhydride (500 mL) were added. The reaction mixture was refluxed in an oil bath at 165°C for 2 hours. Upon completion of the reaction, decompression concentration was carried out to remove excess acetic anhydride. After cooling, a residual oily substance was obtained. Methyl tert-butyl ether (500 mL) was added to the residue and stirred overnight at room temperature. Subsequently, a dark brown solid precipitate precipitated and was separated by filtration. The filter cake was washed with 100 mL of methyl tert-butyl ether (MTBE) and dried under vacuum at 45°C to give 99 g of solid product in 76% yield.

References

[1] Journal of Organic Chemistry, 1992, vol. 57, # 22, p. 5891 - 5899
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 6, p. 828 - 837
[3] Patent: EP503537, 1992, A1
[4] Patent: CN104557704, 2017, B. Location in patent: Paragraph 0042; 0043; 0044
[5] Monatshefte fuer Chemie, 1890, vol. 11, p. 144

PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE Preparation Products And Raw materials

Raw materials

Acetic anhydride 3,4-Pyridinedicarboxylic acid

Preparation Products

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PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE Suppliers

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View Lastest Price from PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Pyridine-3,4-Dicarboxylic Anhydride 4664-08-8
Price
US $1.00-22.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100000KG
Release date
2024-07-31
Career Henan Chemical Co
Product
PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE 4664-08-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-07-11

4664-08-8, PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDERelated Search:

Dimethyl 2,6-Pyridinedicarboxylate 3,5-DIHYDROXYPYRIDINE Dimethyl 2,4-pyridinedicarboxylate 2,4-Pyridinedicarboxylic acid, 2-Methyl ester 2-Pyridinemethanethiol 2,4-PYRIDINECARBOXYLIC ACID, 4-METHYL ESTER 2,4-Pyridinedicarboxylic acid Pyridine hydrochloride 2,6-Pyridinedicarbonitrile 4-Pyridinesulfonamide(6CI,9CI) 2,3,5,6-Tetraaminopyridine trihydrochloride Pyridine trifluoroacetate PYRIDINE-2-THIOAMIDE 2-Pyridinesulfonamide(6CI,7CI,9CI) dimethyl pyridine-3,5-dicarboxylate METHYL ISONICOTINATE Pyridine-N-oxide 2-Pyridinecarbaldehyde oxime

  • CINCHOMERONIC ANHYDRIDE
  • FURO[3,4-C]PYRIDINE-1,3-DIONE
  • PYRIDINE-3,4-DICARBOXYLIC ANHYDRIDE
  • 1,3-DIHYDROFURO[3,4-C]PYRIDINE-1,3-DIONE
  • 3,4-PYRIDINEDICARBOXYLIC ACID ANHYDRIDE
  • 3,4-PYRIDINEDICARBOXYLIC ANHYDRIDE
  • 3,4-Pyridinecarboxylic acid anhydride
  • Pyridine-3,4-dicarboxylic anhydride ,97%
  • 3,4-Pyridinedicarboxylic anhydride ,97%
  • 3,4-Pyridinedicarboxylic anhydride 97%
  • 3,4-Pyridinecarboxylic anhydride, 97%
  • Pyridine-3,4-dicarboxylic acid anhydride
  • 1H,3H-furo[3,4-c]pyridine-1,3-dione
  • Furo[3,4-c]pyridine-1,3-dione, 1,3-Dioxofuro[3,4-c]pyridine
  • 4664-08-8
  • Pyridines