Mezagitamab

Product Name: Mezagitamab
CAS No.: 2227490-52-8
Chemical Name: Mezagitamab
Synonyms: Mezagitamab;Mezagitamab (anti-CD38);Research Grade Mezagitamab;Research Grade Mezagitamab (DHD80803)
CBNumber: CB68081119
Formula Weight: 0
MOL File: Mol file

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Mezagitamab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Mezagitamab Chemical Properties,Usage,Production

Uses

Mezagitamab (TAK-079) is a IgG1λ anti-CD38 monoclonal antibody. Mezagitamab depletes tumor cells expressing CD38 through antibody and complement dependent cytotoxicity. Mezagitamab has potential application in relapsed/refractory multiple myeloma (RRMM) and idiopathic thrombocytopenic purpura (ITP)[1][2][3].

in vivo

Mezagitamab (0.03-100 mg/kg, iv, once or twice a week for 4-13 weeks) leads to the depletion of NK cells, B cells and T cells in cynomolgus monkey models^[4].
Mezagitamab (3 mg/kg, iv,once weekly for 8 weeks) prevents collagen-induced arthritis in cynomolgus monkey models^[4].

Animal Model:	Cynomolgus monkey models^[4]
Dosage:	0.03-100 mg/kg
Administration:	iv, once or twice a week for 4-13 weeks
Result:	Reduced numbers of NK/B/T cells.

Animal Model:	Collagen-induced arthritis in cynomolgus monkey models^[4]
Dosage:	3 mg/kg
Administration:	iv,once weekly for 8 weeks
Result:	Inhibited the progression of arthritis.

References

[1] Abadier M, et al. Mezagitamab induces immunomodulatory effect in patients with relapsed/refractory multiple myeloma (RRMM)[J]. Blood, 2020, 136: 9.
[2] Jadoon Y, et al. Immunotherapy in multiple myeloma. Cancer Treat Res Commun. 2021;29:100468. DOI:10.1016/j.ctarc.2021.100468
[3] Kuter DJ. Novel therapies for immune thrombocytopenia. Br J Haematol. 2022 Mar;196(6):1311-1328. DOI:10.1111/bjh.17872
[4] Roepcke S, et al., Pharmacokinetics and pharmacodynamics of the cytolytic anti-CD38 human monoclonal antibody TAK-079 in monkey - model assisted preparation for the first in human trial. Pharmacol Res Perspect. 2018 Jun;6(3):e00402. DOI:10.1002/prp2.402
[5] Korver W, et al., A Reduction in B, T, and Natural Killer Cells Expressing CD38 by TAK-079 Inhibits the Induction and Progression of Collagen-Induced Arthritis in Cynomolgus Monkeys. J Pharmacol Exp Ther. 2019 Aug;370(2):182-196. DOI:10.1124/jpet.119.256602

Mezagitamab Preparation Products And Raw materials

Raw materials

Preparation Products

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Mezagitamab Suppliers

China 19 United States 1 Global 20

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Mezagitamab

Research Grade Mezagitamab (DHD80803)

Mezagitamab (anti-CD38)

Research Grade Mezagitamab

2227490-52-8