(4-ETHYNYL-PHENYL)-DIPHENYL-AMINE

(4-ETHYNYL-PHENYL)-DIPHENYL-AMINE Property

Melting point:

109.0 to 113.0 °C

Boiling point:

406.6±28.0 °C(Predicted)

Density 

1.15±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

form 

powder to crystal

pka

-4.36±0.30(Predicted)

color 

Light orange to Yellow to Green

Safety

HS Code 

2921.49.5000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

(4-ETHYNYL-PHENYL)-DIPHENYL-AMINE Chemical Properties,Usage,Production

Synthesis

1.0 g (2.93 mmol) of Intermediate 6 (1) was dissolved in 10.0 mL of tetrahydrofuran (THF), and 14.64 mL (14.64 mmol) of 1.0 M tetrabutylammonium fluoride solution in THF was added slowly and dropwise at room temperature. The reaction mixture was stirred at room temperature for 5 hours. Upon completion of the reaction, 50 mL of distilled water was added and the organic layers were combined by extracting three times with 50 mL of dichloromethane. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The residue was separated and purified by silica gel column chromatography to afford 730 mg (2.78 mmol) of intermediate 6 (2) in 93% yield. The product was identified by LC-MS with molecular formula C20H15N and molecular ion peak (M+) m/z of 270.12.

References

[1] Tetrahedron Letters, 2010, vol. 51, # 6, p. 917 - 920
[2] Tetrahedron, 2010, vol. 66, # 29, p. 5479 - 5485
[3] RSC Advances, 2013, vol. 3, # 39, p. 17914 - 17917
[4] Organic Letters, 2012, vol. 14, # 15, p. 3970 - 3973
[5] Patent: US2013/292653, 2013, A1. Location in patent: Paragraph 0136-0137