ChemicalBook > CAS DataBase List > L-Alaninamide, N2-acetyl-L-lysyl-L-α-aspartylglycyl-L-isoleucyl-L-valyl-L-asparaginylglycyl-L-valyl-L-lysyl-
L-Alaninamide, N2-acetyl-L-lysyl-L-α-aspartylglycyl-L-isoleucyl-L-valyl-L-asparaginylglycyl-L-valyl-L-lysyl-
- Product Name
- L-Alaninamide, N2-acetyl-L-lysyl-L-α-aspartylglycyl-L-isoleucyl-L-valyl-L-asparaginylglycyl-L-valyl-L-lysyl-
- CAS No.
- 2243207-00-1
- Chemical Name
- L-Alaninamide, N2-acetyl-L-lysyl-L-α-aspartylglycyl-L-isoleucyl-L-valyl-L-asparaginylglycyl-L-valyl-L-lysyl-
- Synonyms
- α-Synuclein 4554W;α-Synuclein Binding?Peptide?trifluoroacetate salt;L-Alaninamide, N2-acetyl-L-lysyl-L-α-aspartylglycyl-L-isoleucyl-L-valyl-L-asparaginylglycyl-L-valyl-L-lysyl-
- CBNumber
- CB68249388
- Molecular Formula
- C45H80N14O14
- Formula Weight
- 1041.22
- MOL File
- 2243207-00-1.mol
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L-Alaninamide, N2-acetyl-L-lysyl-L-α-aspartylglycyl-L-isoleucyl-L-valyl-L-asparaginylglycyl-L-valyl-L-lysyl- Property
- Boiling point:
- 1532.8±65.0 °C(Predicted)
- Density
- 1.241±0.06 g/cm3(Predicted)
- pka
- 4.21±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- Ac-Lys-Asp-Gly-Ile-Val-Asn-Gly-Val-Lys-Ala-NH?
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L-Alaninamide, N2-acetyl-L-lysyl-L-α-aspartylglycyl-L-isoleucyl-L-valyl-L-asparaginylglycyl-L-valyl-L-lysyl- Chemical Properties,Usage,Production
Uses
α-Synuclein 4554W is an inhibitor of α-Synuclein (aSyn) aggregation with associated toxicity. α-Synuclein 4554W consists of GIVNGVKA sequences, previously identified through intracellular library screening. α-Synuclein 4554W reduces fibril formation of aSyn mutants assocaited with Parkinson’s disease[1].
IC 50
α-synuclein Aggregation
References
[1] Torpey J H, et al. Insights into peptide inhibition of alpha-synuclein aggregation[J]. Frontiers in Neuroscience, 2020, 14: 561462.
L-Alaninamide, N2-acetyl-L-lysyl-L-α-aspartylglycyl-L-isoleucyl-L-valyl-L-asparaginylglycyl-L-valyl-L-lysyl- Preparation Products And Raw materials
Raw materials
Preparation Products
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2243207-00-1, L-Alaninamide, N2-acetyl-L-lysyl-L-α-aspartylglycyl-L-isoleucyl-L-valyl-L-asparaginylglycyl-L-valyl-L-lysyl-Related Search:
α-Synuclein (71-82) (human)
NAC
α-Synuclein (45-54) (human) trifluoroacetate salt
L-Lysine, L-lysyl-L-α-glutamylglycyl-L-valyl-L-leucyl-L-tyrosyl-L-valylglycyl-L-seryl-L-lysyl-L-threonyl-
L-Alanine, glycylglycyl-L-alanyl-L-valyl-L-valyl-L-threonylglycyl-L-valyl-L-threonyl-L-alanyl-L-valyl-