ChemicalBook > CAS DataBase List > 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE
2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE
- Product Name
- 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE
- CAS No.
- 331645-84-2
- Chemical Name
- 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE
- Synonyms
- AQZ-1;AZ 10417808;2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE;8-Quinazolinecarboxamide, 2-[(3,4-dichlorophenyl)amino]-3,4-dihydro-6-nitro-4-oxo-N-2-propen-1-yl-
- CBNumber
- CB6829694
- Molecular Formula
- C18H13Cl2N5O4
- Formula Weight
- 434.23
- MOL File
- 331645-84-2.mol
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2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE Property
- storage temp.
- Store at RT
- solubility
- <10.86mg/ml in DMSO
- form
- solid
- color
- Yellow
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N-Bromosuccinimide Price
TRC
- Product number
- A808213
- Product name
- AZ10417808
- Packaging
- 2.5mg
- Price
- $250
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A4416
- Product name
- AZ10417808
- Packaging
- 5mg
- Price
- $322
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0351637
- Product name
- 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.35
- Updated
- 2021/12/16
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2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE Chemical Properties,Usage,Production
Uses
AZ 10417808 inhibits human caspase-3 with Ki values in the 90 to 800 nM range. AZ 10417808 blocks cellular and biochemical features of apoptosis in cells.
Definition
ChEBI: 2-(3,4-dichloroanilino)-6-nitro-4-oxo-N-prop-2-enyl-1H-quinazoline-8-carboxamide is a member of quinazolines.
Biological Activity
Selective non-peptide inhibitor of caspase-3 (K i = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (K i > 10 μ M). Completely blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells (IC 50 = 14.9 μ M).
2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE Suppliers
331645-84-2, 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDERelated Search:
N-O-TOLYL-GUANIDINE
6-NITROQUINAZOLIN-4(3H)-ONE
N-(3,4-Dichlorophenyl)guanidine
3-(AMINOMETHYL)-N-METHYLBENZAMIDE HYDROCHLORIDE
2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE
6-AMINO-3H-QUINAZOLIN-4-ONE
1,3-Diphenylguanidine