2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE

Product Name: 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE
CAS No.: 331645-84-2
Chemical Name: 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE
Synonyms: AQZ-1;AZ 10417808;2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE;8-Quinazolinecarboxamide, 2-[(3,4-dichlorophenyl)amino]-3,4-dihydro-6-nitro-4-oxo-N-2-propen-1-yl-
CBNumber: CB6829694
Molecular Formula: C18H13Cl2N5O4
Formula Weight: 434.23
MOL File: 331645-84-2.mol

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2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE Property

storage temp.: Store at RT
solubility: <10.86mg/ml in DMSO
form: solid
color: Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A808213
Product name: AZ10417808
Packaging: 2.5mg
Price: $250
Updated: 2021/12/16

ApexBio Technology

Product number: A4416
Product name: AZ10417808
Packaging: 5mg
Price: $322
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0351637
Product name: 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $497.35
Updated: 2021/12/16

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2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE Chemical Properties,Usage,Production

Uses

AZ 10417808 inhibits human caspase-3 with Ki values in the 90 to 800 nM range. AZ 10417808 blocks cellular and biochemical features of apoptosis in cells.

Definition

ChEBI: 2-(3,4-dichloroanilino)-6-nitro-4-oxo-N-prop-2-enyl-1H-quinazoline-8-carboxamide is a member of quinazolines.

Biological Activity

Selective non-peptide inhibitor of caspase-3 (K i = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (K i > 10 μ M). Completely blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells (IC 50 = 14.9 μ M).

2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE Suppliers

China 31 Germany 1 United Kingdom 1 United States 5 Global 38

BOC Sciences

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AdooQ BioScience, LLC

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EMMX Biotechnology LLC

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ApexBio Technology

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United States Biological

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331645-84-2, 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDERelated Search:

N-O-TOLYL-GUANIDINE 6-NITROQUINAZOLIN-4(3H)-ONE N-(3,4-Dichlorophenyl)guanidine 3-(AMINOMETHYL)-N-METHYLBENZAMIDE HYDROCHLORIDE 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE 6-AMINO-3H-QUINAZOLIN-4-ONE 1,3-Diphenylguanidine

2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE

AZ 10417808

AQZ-1

8-Quinazolinecarboxamide, 2-[(3,4-dichlorophenyl)amino]-3,4-dihydro-6-nitro-4-oxo-N-2-propen-1-yl-

331645-84-2

C18H13C12N5O4

C18H13Cl2N5O4