2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-

Product Name: 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-
CAS No.: 2222094-18-8
Chemical Name: 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-
Synonyms: BC-1618;BC1618, 10 mM in DMSO;1-(Dibenzylamino)-3-(4-(trifluoromethyl)phenoxy)propan-2-ol;2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-;Ubiquitin activating enzyme,Mitochondrial Autophagy,fission,Mitophagy,inhibit,Inhibitor,mTORC,Ubiquitin ligase,E1 activating enzyme,AMP-activated protein kinase,BC1618,BC 1618,Ubiquitin conjugating enzyme,AMPK,Fbxo48,LPS,E1/E2/E3 Enzyme,metformin,E3 ligating enzyme,pAmpk,pS6,mitochondrial,insulin,BC-1618,E2 conjugating enzyme
CBNumber: CB68358419
Molecular Formula: C24H24F3NO2
Formula Weight: 415.45
MOL File: 2222094-18-8.mol

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2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- Property

Boiling point:: 518.8±50.0 °C(Predicted)
Density: 1.223±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (240.70 mM; Need ultrasonic)|
form: A solid
pka: 13.68±0.20(Predicted)
color: White to off-white
Water Solubility: Water : < 0.1 mg/mL (insoluble)
InChI: InChI=1S/C24H24F3NO2/c25-24(26,27)21-11-13-23(14-12-21)30-18-22(29)17-28(15-19-7-3-1-4-8-19)16-20-9-5-2-6-10-20/h1-14,22,29H,15-18H2
InChIKey: LGTYABNNHILKHF-UHFFFAOYSA-N
SMILES: C(N(CC1=CC=CC=C1)CC1=CC=CC=C1)C(O)COC1=CC=C(C(F)(F)F)C=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0146843
Product name: BC1618
Purity: 99.83%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-0146843
Product name: BC1618
Purity: 99.83%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0146843
Product name: BC1618
Purity: 99.83%
Packaging: 25mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0146843
Product name: BC1618
Purity: 99.83%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0146843
Product name: BC1618
Purity: 99.83%
Packaging: 100mg
Price: $1350
Updated: 2021/12/16

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2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- Chemical Properties,Usage,Production

Uses

BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation). BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity[1].

Biological Activity

BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation). BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity[1]. BC1618 enhances pAmpkα protein stability during CHX treatment[1].BC1618 displays more than 1,000-fold enhanced activity to stimulate pAmpkα in cells than metformin[1].BC1618 (0.1-2 μM, 16 h) induced dose- and time-dependent increases in pAmpkα and pACC protein levels are also confirmed in human primary-like hepatocytes[1].BC1618 (1 μM) effectively disrupts the interaction between Fbxo48 and pAmpkα, and has no effect on Fbxo48, Ampkα1 or Ampkα2 messenger RNAs[1].BC1618 increases the abundance of a series of autophagic marker proteins during glucose depletion. BC1618 induces phosphorylation of the mTORC1 associated protein Raptor, reducing pS6 levels, all consistent with the known mTOR inhibitory effects exerted by activated Ampk[1]. BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in high-fat-diet-induced obese mice[1].BC1618, appears to be ~1,000-fold more potent than metformin and is extremely well tolerated in mice[1].BC1618 displays excellent oral bioavailability with a peak of 2,000 ng/mL within 0.5h and 500 ng/mL in plasma at 4h after an oral load of 20mg/kg[1].

in vivo

BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in high-fat-diet-induced obese mice^[1].
BC1618, appears to be ~1,000-fold more potent than metformin and is extremely well tolerated in mice^[1].
BC1618 displays excellent oral bioavailability with a peak of 2,000 ng/mL within 0.5h and 500 ng/mL in plasma at 4h after an oral load of 20mg/kg^[1].

Animal Model:	C57BL/6 mice^[1].
Dosage:	2 or 10 mg/kg (challenged with LPS (3 mg/kg) for an additional 18 h).
Administration:	IP, once.
Result:	Reduced lung inflammation in endotoxin treated mice.

Animal Model:	C57BL/6 mice^[1].
Dosage:	15 and 30 mg/kg/d.
Administration:	Drinking water for 3 months.
Result:	Exhibited no obvious toxicity.

References

[1]. Yuan Liu, et al. A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance. Nat Chem Biol. 2021 Mar;17(3):298-306.

2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- Suppliers

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2222094-18-8, 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-Related Search:

2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-

BC-1618

Ubiquitin activating enzyme,Mitochondrial Autophagy,fission,Mitophagy,inhibit,Inhibitor,mTORC,Ubiquitin ligase,E1 activating enzyme,AMP-activated protein kinase,BC1618,BC 1618,Ubiquitin conjugating enzyme,AMPK,Fbxo48,LPS,E1/E2/E3 Enzyme,metformin,E3 ligating enzyme,pAmpk,pS6,mitochondrial,insulin,BC-1618,E2 conjugating enzyme

1-(Dibenzylamino)-3-(4-(trifluoromethyl)phenoxy)propan-2-ol

BC1618, 10 mM in DMSO

2222094-18-8

C24H24F3NO2