1-(4-BROMO-PHENYL)-CYCLOPROPYLAMINE
Uses- Product Name
- 1-(4-BROMO-PHENYL)-CYCLOPROPYLAMINE
- CAS No.
- 345965-54-0
- Chemical Name
- 1-(4-BROMO-PHENYL)-CYCLOPROPYLAMINE
- Synonyms
- 1-(4-BROMOPHENYL)CYCLOPROPANAMINE;1-(4-BROMO-PHENYL)-CYCLOPROPYLAMINE;1-(4-bromophenyl)cyclopropan-1-amine;Cyclopropanamine, 1-(4-bromophenyl)-;1-(4-BROMOPHENYL)CYCLOPROPANAMINE HCL;1-(4-BROMO-PHENYL)-CYCLOPROPYLAMINE ISO 9001：2015 REACH
- CBNumber
- CB6841593
- Molecular Formula
- C9H10BrN
- Formula Weight
- 212.09
- MOL File
- 345965-54-0.mol
1-(4-BROMO-PHENYL)-CYCLOPROPYLAMINE Property
- storage temp.
- 2-8°C(protect from light)
- Appearance
- White to light yellow Solid-liquid mixture
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B614635
- Product name
- 1-(4-Bromophenyl)cyclopropanamine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- V5343
- Product name
- 1-(4-Bromophenyl)cyclopropanamine
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 210797
- Product name
- 1-(4-Bromophenyl)cyclopropanamine
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $109
- Updated
- 2021/12/16
- Product number
- V5343
- Product name
- 1-(4-Bromophenyl)cyclopropanamine
- Packaging
- 1g
- Price
- $189
- Updated
- 2021/12/16
- Product number
- 210797
- Product name
- 1-(4-Bromophenyl)cyclopropanamine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $198
- Updated
- 2021/12/16
1-(4-BROMO-PHENYL)-CYCLOPROPYLAMINE Chemical Properties,Usage,Production
Uses
1-(4-bromobenzene)cyclopropylamine is an amine compound that can be used as a pharmaceutical synthesis intermediate.
Synthesis
623-00-7
925-90-6
345965-54-0
General Method G: Cyclopropanation Reaction (0459) Ethylmagnesium bromide (3.0 M ethyl ether solution, 1.1 eq.) was added slowly and dropwise to a stirred mixture of arylonitrile (1 eq.) and tetraisopropoxytitanium (1.7 eq.) at -70 °C. The reaction mixture was gradually warmed to 25 °C and stirred continuously for 1 hour. Subsequently, boron trifluoride ethyl ether complex (3 eq.) was added dropwise to the reaction system at 25 °C. After the dropwise addition was completed, stirring of the reaction mixture was continued for 2 hours. After completion of the reaction, the reaction was quenched with 2M aqueous hydrochloric acid. Next, the pH of the reaction solution was adjusted to alkaline with 2M aqueous sodium hydroxide solution. The organic material in the reaction solution was extracted with ether. The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, ratio from 10:1 to 1:1 gradient elution) to obtain the target product 1-arylcyclopropylamine. Example 64: Synthesis of quinuclidinyl cyclic-3-yl 1-(biphenyl-4-yl)cyclopropyl carbamate 4-Bromobenzonitrile (3.00 g, 16.5 mmol) was converted to 1-(4-bromophenyl)cyclopropylamine (1.80 g, 51% yield) according to General Method G. The product was a yellow solid.
References
[1] Patent: US9126993, 2015, B2. Location in patent: Page/Page column 49; 87
[2] Patent: WO2016/145046, 2016, A1. Location in patent: Page/Page column 64; 65; 70; 71
1-(4-BROMO-PHENYL)-CYCLOPROPYLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(4-BROMO-PHENYL)-CYCLOPROPYLAMINE manufacturers
- Product
- 1-(4-BROMO-PHENYL)-CYCLOPROPYLAMINE 345965-54-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-08