BIBX 1382 DIHYDROCHLORIDE

Product Name: BIBX 1382 DIHYDROCHLORIDE
CAS No.: 196612-93-8
Chemical Name: BIBX 1382 DIHYDROCHLORIDE
Synonyms: Falnid;CS-928;Falnidamol;Unii-0mu316797d;Falnidamol [inn];BIBX 1382 DIHYDROCHLORIDE;FALNIDAMOL; BIBX-1382; BIBX 1382;8-(3-Chloro-4-fluoroanilino)-2-((1-methyl-4-piperidyl)amino)pyrimido(5,4-D)pyrimidine;N4-(3-chloro-4-fluoro-phenyl)-N6-(1-methyl-4-piperidyl)pyrimido[5,4-d]pyrimidine-4,6-diamine;N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-2,8-diamine
CBNumber: CB6842590
Molecular Formula: C18H19ClFN7
Formula Weight: 387.84
MOL File: 196612-93-8.mol

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BIBX 1382 DIHYDROCHLORIDE Property

Melting point:: >217°C (dec.)
Boiling point:: 552.0±60.0 °C(Predicted)
Density: 1.427
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 8?+-.0.10(Predicted)
color: Pale Yellow to Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 324832
Product name: EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem
Packaging: 5MG
Price: $318
Updated: 2024/03/01

Cayman Chemical

Product number: 29630
Product name: BIBX1382
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 29630
Product name: BIBX1382
Packaging: 25mg
Price: $576
Updated: 2024/03/01

Cayman Chemical

Product number: 29630
Product name: BIBX1382
Packaging: 5mg
Price: $150
Updated: 2024/03/01

Cayman Chemical

Product number: 29630
Product name: BIBX1382
Packaging: 10mg
Price: $280
Updated: 2024/03/01

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BIBX 1382 DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Falnidamol is a novel ErbB receptor kinase inhibitor that is more potent at inhibiting signaling induced by TGF-α than that induced by neuregulin1-β1 or anti-ErbB2 agonist antibodies.

Uses

BIBX 1382 Dihydrochloride, is a potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM).

Definition

ChEBI: N4-(3-chloro-4-fluorophenyl)-N6-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-4,6-diamine is a substituted aniline.

Biological Activity

Potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC 50 = 3.4 μ M) and a range of other related tyrosine kinases (IC 50 > 10 μ M). Oral administration inhibits growth of established human xenografts in athymic mice.

References

1. f. f. solca, a. baum, e. langkopf, g. dahmann, k. h. heider, f. himmelsbach and j. c. van meel, j pharmacol exp ther 2004, 311, 502-509.

BIBX 1382 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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BIBX 1382 DIHYDROCHLORIDE Suppliers

China 47 Germany 1 India 1 United Kingdom 1 United States 14 Global 64

Shanghai Boyle Chemical Co., Ltd.

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View Lastest Price from BIBX 1382 DIHYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: BIBX 1382 dihydrochloride,N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diaminedihydrochloride 196612-93-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-30

196612-93-8, BIBX 1382 DIHYDROCHLORIDERelated Search:

Piperidin-4-yl-pyrimidin-2-yl-amine dihydrochloride BIBX 1382 DIHYDROCHLORIDE

FALNIDAMOL; BIBX-1382; BIBX 1382

BIBX 1382 dihydrochloride,N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diaminedihydrochloride

CS-928

BIBX 1382 DIHYDROCHLORIDE

8-(3-Chloro-4-fluoroanilino)-2-((1-methyl-4-piperidyl)amino)pyrimido(5,4-D)pyrimidine

Falnidamol

Falnidamol [inn]

Pyrimido(5,4-D)pyrimidine-2,8-diamine, N8-(3-chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-

Unii-0mu316797d

N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diaminedihydrochloride

Falnid

N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-2,8-diamine

N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-2,8-diamine BIBX 1382

N8-(3-Chloro-4-fluorophenyl)-N2-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-2,8-diamine

N4-(3-chloro-4-fluoro-phenyl)-N6-(1-methyl-4-piperidyl)pyrimido[5,4-d]pyrimidine-4,6-diamine

N8-(3-CHLORO-4-FLUOROPHENYL)-N2-(1-METHYL-4-PIPERIDINYL)-PYRIMIDO[5,4-D]PYRIMIDINE-2,8-DIAMINE DIHYDROCHLORIDE

196612-93-8

C18H19ClFN7

C18H21Cl3FN7

C18H19ClFN72HCl