BIBX 1382 DIHYDROCHLORIDE

Product Name: BIBX 1382 DIHYDROCHLORIDE
CAS No.: 196612-93-8
Chemical Name: BIBX 1382 DIHYDROCHLORIDE
Synonyms: Falnid;CS-928;Falnidamol;Unii-0mu316797d;Falnidamol [inn];BIBX 1382 DIHYDROCHLORIDE;Falnidamol, 10 mM in DMSO;EGFR Inhibitor II, BIBX1382;FALNIDAMOL; BIBX-1382; BIBX 1382;8-(3-Chloro-4-fluoroanilino)-2-((1-methyl-4-piperidyl)amino)pyrimido(5,4-D)pyrimidine
CBNumber: CB6842590
Molecular Formula: C18H19ClFN7
Formula Weight: 387.84
MOL File: 196612-93-8.mol

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BIBX 1382 DIHYDROCHLORIDE Property

Melting point:: >217°C (dec.)
Boiling point:: 552.0±60.0 °C(Predicted)
Density: 1.427
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 8?+-.0.10(Predicted)
form: Solid
color: Pale Yellow to Yellow
Water Solubility: water: 1mg/mL
DMSO: 25mg/mL

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 324832
Product name: EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem
Packaging: 5MG
Price: $318
Updated: 2024/03/01

Cayman Chemical

Product number: 29630
Product name: BIBX1382
Packaging: 1mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 29630
Product name: BIBX1382
Packaging: 25mg
Price: $576
Updated: 2024/03/01

Cayman Chemical

Product number: 29630
Product name: BIBX1382
Packaging: 5mg
Price: $150
Updated: 2024/03/01

Cayman Chemical

Product number: 29630
Product name: BIBX1382
Packaging: 10mg
Price: $280
Updated: 2024/03/01

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BIBX 1382 DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Falnidamol is a novel ErbB receptor kinase inhibitor that is more potent at inhibiting signaling induced by TGF-α than that induced by neuregulin1-β1 or anti-ErbB2 agonist antibodies.

Uses

BIBX 1382 Dihydrochloride, is a potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM).

Definition

ChEBI: N4-(3-chloro-4-fluorophenyl)-N6-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-4,6-diamine is a substituted aniline.

Biological Activity

Potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC 50 = 3.4 μ M) and a range of other related tyrosine kinases (IC 50 > 10 μ M). Oral administration inhibits growth of established human xenografts in athymic mice.

in vivo

Falnidamol (BIBX 1382; p.o.; 10 mg/kg/day; 16 days) completely suppressed tumor growth of human A431 xenografts with respective a T/C value of 15% after 2 weeks of treatment^[2].
Falnidamol (50 mg/kg/day for 2 weeks) results in dephosphorylation of the EGF receptor in A431 xenograft-bearing mice^[2].
With Falnidamol (p.o.; 10 mg/kg/day; 16 days), the C_4h is 2222 nM and the C_24h is 244 nM^[2].

Animal Model:	Five- to six-week-old athymic NMRI-nu/nu female mice (21-31 g) with A431, FaDu, or HN5 cells^[2]
Dosage:	10 mg/kg
Administration:	p.o.; daily; 16 days
Result:	Completely suppressed tumor growth of human A431 xenografts with respective T/C values of 15 and 6% after 2 weeks of treatment.

Animal Model:	Five- to six-week-old athymic NMRI-nu/nu female mice (21–31 g) with A431 cells^[2]
Dosage:	10 mg/kg (Pharmacokinetic Analysis)
Administration:	p.o.; daily; 16 days
Result:	The C_4h is 2222 nM and the C_24h is 244 nM.

IC 50

EGFR: 3 nM (IC₅₀); ErbB2: 3.4 μM (IC₅₀)

References

1. f. f. solca, a. baum, e. langkopf, g. dahmann, k. h. heider, f. himmelsbach and j. c. van meel, j pharmacol exp ther 2004, 311, 502-509.

BIBX 1382 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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BIBX 1382 DIHYDROCHLORIDE Suppliers

China 73 Germany 1 India 1 United Kingdom 1 United States 15 Global 91

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View Lastest Price from BIBX 1382 DIHYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: BIBX 1382 dihydrochloride,N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diaminedihydrochloride 196612-93-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-30

196612-93-8, BIBX 1382 DIHYDROCHLORIDERelated Search:

Piperidin-4-yl-pyrimidin-2-yl-amine dihydrochloride BIBX 1382 DIHYDROCHLORIDE

FALNIDAMOL; BIBX-1382; BIBX 1382

BIBX 1382 dihydrochloride,N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diaminedihydrochloride

CS-928

BIBX 1382 DIHYDROCHLORIDE

8-(3-Chloro-4-fluoroanilino)-2-((1-methyl-4-piperidyl)amino)pyrimido(5,4-D)pyrimidine

Falnidamol

Falnidamol [inn]

Pyrimido(5,4-D)pyrimidine-2,8-diamine, N8-(3-chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-

Unii-0mu316797d

N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diaminedihydrochloride

Falnid

N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-2,8-diamine

N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-2,8-diamine BIBX 1382

N8-(3-Chloro-4-fluorophenyl)-N2-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-2,8-diamine

N4-(3-chloro-4-fluoro-phenyl)-N6-(1-methyl-4-piperidyl)pyrimido[5,4-d]pyrimidine-4,6-diamine

N8-(3-CHLORO-4-FLUOROPHENYL)-N2-(1-METHYL-4-PIPERIDINYL)-PYRIMIDO[5,4-D]PYRIMIDINE-2,8-DIAMINE DIHYDROCHLORIDE

Falnidamol, 10 mM in DMSO

EGFR Inhibitor II, BIBX1382

196612-93-8

C18H19ClFN7

C18H21Cl3FN7

C18H19ClFN72HCl