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BIBX 1382 DIHYDROCHLORIDE

Product Name
BIBX 1382 DIHYDROCHLORIDE
CAS No.
196612-93-8
Chemical Name
BIBX 1382 DIHYDROCHLORIDE
Synonyms
Falnid;CS-928;Falnidamol;Unii-0mu316797d;Falnidamol [inn];BIBX 1382 DIHYDROCHLORIDE;FALNIDAMOL; BIBX-1382; BIBX 1382;8-(3-Chloro-4-fluoroanilino)-2-((1-methyl-4-piperidyl)amino)pyrimido(5,4-D)pyrimidine;N4-(3-chloro-4-fluoro-phenyl)-N6-(1-methyl-4-piperidyl)pyrimido[5,4-d]pyrimidine-4,6-diamine;N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-2,8-diamine
CBNumber
CB6842590
Molecular Formula
C18H19ClFN7
Formula Weight
387.84
MOL File
196612-93-8.mol
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BIBX 1382 DIHYDROCHLORIDE Property

Melting point:
>217°C (dec.)
Boiling point:
552.0±60.0 °C(Predicted)
Density 
1.427
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
8?+-.0.10(Predicted)
color 
Pale Yellow to Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
324832
Product name
EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem
Packaging
5MG
Price
$318
Updated
2024/03/01
Cayman Chemical
Product number
29630
Product name
BIBX1382
Packaging
1mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
29630
Product name
BIBX1382
Packaging
25mg
Price
$576
Updated
2024/03/01
Cayman Chemical
Product number
29630
Product name
BIBX1382
Packaging
5mg
Price
$150
Updated
2024/03/01
Cayman Chemical
Product number
29630
Product name
BIBX1382
Packaging
10mg
Price
$280
Updated
2024/03/01
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BIBX 1382 DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Falnidamol is a novel ErbB receptor kinase inhibitor that is more potent at inhibiting signaling induced by TGF-α than that induced by neuregulin1-β1 or anti-ErbB2 agonist antibodies.

Uses

BIBX 1382 Dihydrochloride, is a potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM).

Definition

ChEBI: N4-(3-chloro-4-fluorophenyl)-N6-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-4,6-diamine is a substituted aniline.

Biological Activity

Potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC 50 = 3.4 μ M) and a range of other related tyrosine kinases (IC 50 > 10 μ M). Oral administration inhibits growth of established human xenografts in athymic mice.

References

1. f. f. solca, a. baum, e. langkopf, g. dahmann, k. h. heider, f. himmelsbach and j. c. van meel, j pharmacol exp ther 2004, 311, 502-509.

BIBX 1382 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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BIBX 1382 DIHYDROCHLORIDE Suppliers

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View Lastest Price from BIBX 1382 DIHYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
BIBX 1382 dihydrochloride,N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diaminedihydrochloride 196612-93-8
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-30

196612-93-8, BIBX 1382 DIHYDROCHLORIDERelated Search:

Piperidin-4-yl-pyrimidin-2-yl-amine dihydrochloride BIBX 1382 DIHYDROCHLORIDE

  • FALNIDAMOL; BIBX-1382; BIBX 1382
  • BIBX 1382 dihydrochloride,N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diaminedihydrochloride
  • CS-928
  • BIBX 1382 DIHYDROCHLORIDE
  • 8-(3-Chloro-4-fluoroanilino)-2-((1-methyl-4-piperidyl)amino)pyrimido(5,4-D)pyrimidine
  • Falnidamol
  • Falnidamol [inn]
  • Pyrimido(5,4-D)pyrimidine-2,8-diamine, N8-(3-chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-
  • Unii-0mu316797d
  • N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diaminedihydrochloride
  • Falnid
  • N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-2,8-diamine
  • N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-2,8-diamine BIBX 1382
  • N8-(3-Chloro-4-fluorophenyl)-N2-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-2,8-diamine
  • N4-(3-chloro-4-fluoro-phenyl)-N6-(1-methyl-4-piperidyl)pyrimido[5,4-d]pyrimidine-4,6-diamine
  • N8-(3-CHLORO-4-FLUOROPHENYL)-N2-(1-METHYL-4-PIPERIDINYL)-PYRIMIDO[5,4-D]PYRIMIDINE-2,8-DIAMINE DIHYDROCHLORIDE
  • 196612-93-8
  • C18H19ClFN7
  • C18H21Cl3FN7
  • C18H19ClFN72HCl