AMN082 DIHYDROCHLORIDE
- Product Name
- AMN082 DIHYDROCHLORIDE
- CAS No.
- 83027-13-8
- Chemical Name
- AMN082 DIHYDROCHLORIDE
- Synonyms
- AMN 082;AMN082 free base;AMN 082 dihydrochlor;AMN082 DIHYDROCHLORIDE;N,N'-bis(diphenylMethyl)ethylenediaMine;1,2-Ethanediamine, N1,N2-bis(diphenylmethyl)-;N,N'-DIBENZHYDRYLETHANE-1,2-DIAMINE DIHYDROCHLORIDE;N,N'-Bis(diphenylmethyl)-1,2-ethandiamine dihydrochloride;N,N'-BIS(DIPHENYLMETHYL)-1,2-ETHANEDIAMINE DIHYDROCHLORIDE;locomotor,allosteric,AMN082 free base,AMN 082,blood-brain,stress,hormone,Inhibitor,AMN-082,inhibit,sensitization,AMN-082 free base,oral,Metabotropic glutamate receptors,mGluR,barrier
- CBNumber
- CB6849458
- Molecular Formula
- C28H28N2
- Formula Weight
- 392.54
- MOL File
- 83027-13-8.mol
AMN082 DIHYDROCHLORIDE Property
- Melting point:
- 105.5 °C
- Boiling point:
- 533.7±45.0 °C(Predicted)
- Density
- 1.086±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at +4°C
- solubility
- DMSO : 12.5 mg/mL (31.84 mM; ultrasonic and warming and heat to 60°C)
- pka
- 8.38±0.29(Predicted)
N-Bromosuccinimide Price
- Product number
- 2385
- Product name
- AMN082dihydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $124
- Updated
- 2021/12/16
- Product number
- 2385
- Product name
- AMN082dihydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $521
- Updated
- 2021/12/16
- Product number
- 254625
- Product name
- AMN 082 dihydrochloride
- Packaging
- 10mg
- Price
- $366
- Updated
- 2021/12/16
- Product number
- BIO0000325
- Product name
- AMN-082
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.74
- Updated
- 2021/12/16
AMN082 DIHYDROCHLORIDE Chemical Properties,Usage,Production
Uses
AMN082 dihydrochloride is a selective agonist at mGluR-7.
Definition
ChEBI: N,N'-bis(diphenylmethyl)ethane-1,2-diamine is a diamine that is ethane-1,2-diamine in which both amino groups are substituted by diphenylmethyl groups. It is an allosteric agonist of the metabotropic glutamate receptor 7 (mGluR7). It has a role as a metabotropic glutamate receptor agonist and a neuroprotective agent. It is a diarylmethane, a secondary amino compound, a diamine and a member of benzenes. It is a conjugate base of a N,N'-bis(diphenylmethyl)ethane-1,2-diamine(2+).
Biological Activity
The first selective mGlu 7 agonist. Potently inhibits cAMP accumulation and stimulates GTP γ S binding in recombinant cells and on membranes expressing mGlu 7 (EC 50 = 64-290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μ M. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats.
AMN082 DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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