ChemicalBook > CAS DataBase List > AMN082 DIHYDROCHLORIDE

AMN082 DIHYDROCHLORIDE

Product Name
AMN082 DIHYDROCHLORIDE
CAS No.
83027-13-8
Chemical Name
AMN082 DIHYDROCHLORIDE
Synonyms
AMN 082;AMN082 free base;AMN 082 dihydrochlor;AMN082 DIHYDROCHLORIDE;N,N'-bis(diphenylMethyl)ethylenediaMine;1,2-Ethanediamine, N1,N2-bis(diphenylmethyl)-;N,N'-DIBENZHYDRYLETHANE-1,2-DIAMINE DIHYDROCHLORIDE;N,N'-Bis(diphenylmethyl)-1,2-ethandiamine dihydrochloride;N,N'-BIS(DIPHENYLMETHYL)-1,2-ETHANEDIAMINE DIHYDROCHLORIDE;locomotor,allosteric,AMN082 free base,AMN 082,blood-brain,stress,hormone,Inhibitor,AMN-082,inhibit,sensitization,AMN-082 free base,oral,Metabotropic glutamate receptors,mGluR,barrier
CBNumber
CB6849458
Molecular Formula
C28H28N2
Formula Weight
392.54
MOL File
83027-13-8.mol
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AMN082 DIHYDROCHLORIDE Property

Melting point:
105.5 °C
Boiling point:
533.7±45.0 °C(Predicted)
Density 
1.086±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at +4°C
solubility 
DMSO : 12.5 mg/mL (31.84 mM; ultrasonic and warming and heat to 60°C)
pka
8.38±0.29(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
2385
Product name
AMN082dihydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$124
Updated
2021/12/16
Tocris
Product number
2385
Product name
AMN082dihydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$521
Updated
2021/12/16
Usbiological
Product number
254625
Product name
AMN 082 dihydrochloride
Packaging
10mg
Price
$366
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BIO0000325
Product name
AMN-082
Purity
95.00%
Packaging
5MG
Price
$501.74
Updated
2021/12/16
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AMN082 DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

AMN082 dihydrochloride is a selective agonist at mGluR-7.

Definition

ChEBI: N,N'-bis(diphenylmethyl)ethane-1,2-diamine is a diamine that is ethane-1,2-diamine in which both amino groups are substituted by diphenylmethyl groups. It is an allosteric agonist of the metabotropic glutamate receptor 7 (mGluR7). It has a role as a metabotropic glutamate receptor agonist and a neuroprotective agent. It is a diarylmethane, a secondary amino compound, a diamine and a member of benzenes. It is a conjugate base of a N,N'-bis(diphenylmethyl)ethane-1,2-diamine(2+).

Biological Activity

The first selective mGlu 7 agonist. Potently inhibits cAMP accumulation and stimulates GTP γ S binding in recombinant cells and on membranes expressing mGlu 7 (EC 50 = 64-290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μ M. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats.

AMN082 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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AMN082 DIHYDROCHLORIDE Suppliers

China 35 Germany 2 India 1 Switzerland 2 United Kingdom 4 United States 4 Global 48
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83027-13-8, AMN082 DIHYDROCHLORIDERelated Search:

AMN082 DIHYDROCHLORIDE 1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE

  • AMN 082
  • N,N'-DIBENZHYDRYLETHANE-1,2-DIAMINE DIHYDROCHLORIDE
  • N,N'-BIS(DIPHENYLMETHYL)-1,2-ETHANEDIAMINE DIHYDROCHLORIDE
  • AMN082 DIHYDROCHLORIDE
  • N,N'-Bis(diphenylmethyl)-1,2-ethandiamine dihydrochloride
  • N,N'-bis(diphenylMethyl)ethylenediaMine
  • AMN 082 dihydrochlor
  • AMN082 free base
  • locomotor,allosteric,AMN082 free base,AMN 082,blood-brain,stress,hormone,Inhibitor,AMN-082,inhibit,sensitization,AMN-082 free base,oral,Metabotropic glutamate receptors,mGluR,barrier
  • 1,2-Ethanediamine, N1,N2-bis(diphenylmethyl)-
  • 83027-13-8
  • C28H28N22ClH
  • C28H28N22HCl
  • Glutamate
  • Glutamate receptor