ChemicalBook > CAS DataBase List > 3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine

3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine

Product Name
3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine
CAS No.
20348-23-6
Chemical Name
3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine
Synonyms
Compound Fr16627;2H,3H,4H-pyrido[3,2-b][1,4]oxazine;3,4-Dihydro-2H-pyrido[3,2-b]oxazine;2,3-dihydropyrido[3,2-b][1,4]oxazine;3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE;2H-Pyrido[3,2-b]-1,4-oxazine, 3,4-dihydro-;3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine ISO 9001：2015 REACH
CBNumber
CB6853297
Molecular Formula
C7H8N2O
Formula Weight
136.15
MOL File
20348-23-6.mol
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3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine Property

Melting point:
85 °C
Boiling point:
285.7±29.0 °C(Predicted)
Density 
1.168
storage temp. 
2-8°C(protect from light)
pka
9.82±0.20(Predicted)
Appearance
White to off-white Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D451550
Product name
3,4-Dihydro-2h-pyrido[3,2-b][1,4]oxazine
Packaging
250mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
048685
Product name
3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine
Purity
>95%
Packaging
500mg
Price
$65
Updated
2021/12/16
ChemScene
Product number
CS-0039841
Product name
3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine
Purity
99.63%
Packaging
1g
Price
$78
Updated
2021/12/16
AK Scientific
Product number
0424AB
Product name
3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine
Packaging
100mg
Price
$88
Updated
2021/12/16
Matrix Scientific
Product number
048685
Product name
3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine
Purity
>95%
Packaging
1g
Price
$159
Updated
2021/12/16
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3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine Chemical Properties,Usage,Production

Definition

ChEBI: 3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine is a secondary amine.

Synthesis

20348-09-8

20348-23-6

(a) Synthesis of 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine: To a solution of 2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one (5.00 g, 33.3 mmol) in tetrahydrofuran (THF, 40 mL) was slowly added lithium aluminium hydroxide (66.6 mL, 1.0 M THF solution. 66.6 mmol). After addition, the reaction mixture was heated to reflux. After 18 hours of reaction, the reaction was cooled to 0 °C and water (4 mL), sodium hydroxide solution (4 mL, 15%) and water (10 mL) were added sequentially to quench the reaction. Subsequently, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated to afford the target product 3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine (3.87 g, 85% yield) as a blue-gray powder. The product was characterized by 1H NMR (500 MHz, DMSO-d6): δ 7.53 (dd, J=4.5,1.0 Hz, 1H), 6.90-6.89 (m, 1H), 6.61 (br s, 1H), 6.44 (dd, J=8.0,3.0 Hz, 1H), 4.08 (t, J=4.5 Hz, 2H), 3.39- 3.36 (m, 2H); mass spectrum (ESI) m/e 131 (M+H)+.

References

[1] Patent: WO2007/53131, 2007, A2. Location in patent: Page/Page column 133
[2] Patent: EP1226138, 2004, B1
[3] Acta Chemica Scandinavica (1947-1973), 1969, vol. 23, p. 2322 - 2324
[4] Patent: US2008/305169, 2008, A1
[5] Patent: US2007/10670, 2007, A1. Location in patent: Page/Page column 92

3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine Suppliers

Belgium 1 China 70 Germany 1 India 1 United Kingdom 1 United States 11 Global 85
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
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64
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
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800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
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58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
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58
Shanghai Keepontech Co.,Ltd
Tel
021-54849683 13601642561
Fax
+86-21-54375689
Email
sales@keepontech.com
Country
China
ProdList
998
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59
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
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55
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View Lastest Price from 3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine 20348-23-6
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-13
Shanghai Rlavie Technology Co ltd
Product
3,4-Dihydro-2H-pyrido[3,2-b]-1,4-oxazine 20348-23-6
Price
US $0.00-0.00/kg
Min. Order
0.0001kg
Purity
98%min
Supply Ability
100kgs/month
Release date
2022-05-10

20348-23-6, 3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazineRelated Search:

2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one 7-CHLORO-2H-PYRIDO[3,2-B]-1,4-OXAZIN-3(4H)ONE 2-(2-HYDROXYETHYL)-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE 2-[2-(4-ETHYLPIPERAZINO)ETHYL]-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE BUTTPARK 26\07-99 2-(3-OXO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZIN-2-YL)ETHYL 4-CHLOROBENZENECARBOXYLATE BUTTPARK 26\07-94 BUTTPARK 26\07-91 BUTTPARK 26\07-96 BUTTPARK 26\07-95 2-(3-OXO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZIN-2-YL)ETHYL 4-FLUOROBENZENECARBOXYLATE BUTTPARK 26\07-100 2-[2-(4-BENZYLPIPERAZINO)ETHYL]-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE BUTTPARK 26\07-97 2-(3-OXO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZIN-2-YL)ETHYL 2-FUROATE BUTTPARK 26\07-98 2-(3-OXO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZIN-2-YL)ETHYL 4-NITROBENZENECARBOXYLATE BUTTPARK 26\07-92

  • 3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE
  • 3,4-Dihydro-2H-pyrido[3,2-b]oxazine
  • 2H,3H,4H-pyrido[3,2-b][1,4]oxazine
  • 2,3-dihydropyrido[3,2-b][1,4]oxazine
  • 2H-Pyrido[3,2-b]-1,4-oxazine, 3,4-dihydro-
  • 3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine ISO 9001：2015 REACH
  • Compound Fr16627
  • 20348-23-6
  • Heterocyclic Series