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(S)-2-Phenylpyrrolidine

Product Name
(S)-2-Phenylpyrrolidine
CAS No.
59347-91-0
Chemical Name
(S)-2-Phenylpyrrolidine
Synonyms
(S)-2-Phenylpyrrolidine;(2S)-2-Phenylpyrrolidine;(2S)-2α-Phenylpyrrolidine;(S)-2-PHENYLPYRROLIDINE HCl;Pyrrolidine, 2-phenyl-, (2S)-
CBNumber
CB6875464
Molecular Formula
C10H13N
Formula Weight
147.22
MOL File
59347-91-0.mol
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(S)-2-Phenylpyrrolidine Property

Boiling point:
237.0±19.0 °C(Predicted)
Density 
0.988±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
10.13±0.10(Predicted)
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P998490
Product name
(S)-2-Phenylpyrrolidine
Packaging
50mg
Price
$130
Updated
2021/12/16
Apolloscientific
Product number
OR932248
Product name
(S)-2-Phenylpyrrolidine
Purity
95%
Packaging
250mg
Price
$225
Updated
2021/12/16
Activate Scientific
Product number
AS7522-A
Product name
(S)-2-Phenylpyrrolidine
Purity
97+% ee
Packaging
250mg
Price
$290
Updated
2021/12/16
Apolloscientific
Product number
OR932248
Product name
(S)-2-Phenylpyrrolidine
Purity
95%
Packaging
1g
Price
$495
Updated
2021/12/16
Activate Scientific
Product number
AS7522-A
Product name
(S)-2-Phenylpyrrolidine
Purity
97+% ee
Packaging
1g
Price
$592
Updated
2021/12/16
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(S)-2-Phenylpyrrolidine Chemical Properties,Usage,Production

Description

(S)-2-Phenylpyrrolidine is an amine that has been synthesized for use in research. It is chiral and can exist as either the levorotatory or dextrorotatory form. It interacts with the tropomyosin receptor, which is a protein found on the surface of muscle cells. This interaction prevents calcium ions from binding to tropomyosin, thereby preventing muscle contraction.

Uses

(S)-2-Phenylpyrrolidine has been shown to be effective in treating neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Research also suggests that this drug may be effective at preventing aldehyde toxicity mediated by the enzyme acetaldehyde dehydrogenase 2 (ALDH2).

Reactions

(S)-2-Phenylpyrrolidine could be react with N-{3-nitro-4-[(oxan-4-ylmethyl)amino]benzenesulfonyl}-4-{2-oxo-7-azaspiro[3.5]nonan-7- y l}-2-[( 11 R, 15S)-4-{[2-(trimethy Isi ly l)ethoxy]methy I}- 13, 16-dioxa-2,4, 10- triazatetracyclo[7.7.0.0A{3,7}.0A{11,15}]hexadeca-1(9),2,5,7-tetraen-10-yl]benzamide to synthsize a intermediate of BCL-2 inhibitor. It can also be use in the preparation of the Inhibitors of ubiquitin specific protease 19 (USP19) through amine group coupling.

Synthesis

Into a 100 mL round-bottom flask were added tert-butyl (2S)- 2-phenylpyrrolidine-1-carboxylate (70 mg, 0.3 mmol, 1.0 eq) and CHsCh .0 mL), TFA (0.5 mL) at 25°C. The resulting mixture was stirred for 3 hours at 25°C. The resulting mixture was concentrated under reduced pressure. This resulted in (S)-2-Phenylpyrrolidine (40 mg, 96.0%) as colorless oil.

(S)-2-Phenylpyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-2-Phenylpyrrolidine Suppliers

China 81 India 1 United States 8 Global 91
Accela ChemBio Inc.
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Matrix Scientific
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Small Molecules, Inc.
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View Lastest Price from (S)-2-Phenylpyrrolidine manufacturers

Career Henan Chemical Co
Product
(2S)-2-phenylpyrrolidine 59347-91-0
Price
US $3.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-08-07

59347-91-0, (S)-2-PhenylpyrrolidineRelated Search:

N-Vinyl-2-pyrrolidone Povidone iodine N-Methyl-2-pyrrolidone Polyvinylpyrrolidone Pyrrolidine (S)-2-(4-Fluorophenyl)pyrrolidine (S)-2-(4-CHLOROPHENYL)PYRROLIDINE METHYL-2-PYRROLIDONE (S)-2-(4-BROMOPHENYL)PYRROLIDINE 2-PHENYLPYRROLIDINE 2-(2-PHENOXYPHENYL)-PYRROLIDINE 3-(4-FLUORO-PHENYL)-PYRROLIDINE (3S,4R)-4-(4-FLUOROPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID TERT-BUTYL (3S,4R)-4-(2-METHOXYPHENYL)PYRROLIDIN-3-YLCARBAMATE (3S,4R)-4-(3-FLUOROPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID (R)-1-BOC-3-PHENYL-PYRROLIDINE 3-(3-FLUOROPHENYL)PYRROLIDINE (S)-2-(4-METHOXYPHENYL)PYRROLIDINE

  • (S)-2-Phenylpyrrolidine
  • (2S)-2-Phenylpyrrolidine
  • (2S)-2α-Phenylpyrrolidine
  • (S)-2-PHENYLPYRROLIDINE HCl
  • Pyrrolidine, 2-phenyl-, (2S)-
  • 59347-91-0
  • pharmaceutical intermediate
  • Chiral heterocyclic compounds