thonzylamine hydrochloride
- Product Name
- thonzylamine hydrochloride
- CAS No.
- 63-56-9
- Chemical Name
- thonzylamine hydrochloride
- Synonyms
- NH 188;Anahist;Resistab;Novohetramin;Thonzylamine HCl;Thonzylamine HCl 98%;Thonzilamine hydrochloride;Neohetramine hydrochloride;thonzylamine hydrochloride;thonzylamine hydrochloride ISO 9001：2015 REACH
- CBNumber
- CB6875530
- Molecular Formula
- C16H22N4O.ClH
- Formula Weight
- 322.84
- MOL File
- 63-56-9.mol
thonzylamine hydrochloride Property
- Melting point:
- 173-176°
- Boiling point:
- bp2.2 185-187°
- Density
- 1.2562 (rough estimate)
- refractive index
- 1.5800 (estimate)
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- EPA Substance Registry System
- Thonzylamine hydrochloride (63-56-9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H312Harmful in contact with skin
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
thonzylamine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White, crystalline powder; faint odor. Very soluble in water; freely soluble in alcohol and chloroform; practically insoluble in ether and benzene; pH 5.0–6.0 (2% solution).
Originator
Neohetramine,Warner Lambert,US,1948
Uses
Medicine (antihistamine).
Definition
ChEBI: Thonzylamine hydrochloride is a member of methoxybenzenes.
Manufacturing Process
54 g of 2-(p-methoxybenzyl)aminopyrimidine and 12.0 g of sodamide were suspended in 250 cc of toluene and were refluxed for 31 hours. To the thus prepared sodium salt of 2-(p-methoxybenzyl)aminopyrimidine, 28.1 g of dimethylaminoethyl chloride were added and refluxed under continuous stirring for 26 hours. After cooling, the reaction mixture was extracted with dilute hydrochloric acid at about pH 5.0, removing the product thus formed containing only very little of the unreacted 2-(p_x0002_methoxybenzyl)aminopyrimidine. This solution was then made alkaline to liberate the free base of the product, which was extracted with ether. The ether solution was evaporated and the residue vacuum distilled. The product, 2-(p-methoxybenzyl-dimethylaminoethyl)aminopyrimidine forms an oily liquid, boiling point 185°C to 187°C at 2.2 mm.
Therapeutic Function
Antihistaminic
General Description
Thonzylamine hydrochloride,2-[[2-(dimethylamino)-ethyl](p-methoxybenzyl)amino]pyrimidine hydrochloride, is a white crystallinepowder soluble in water (1:1), in alcohol (1:6), and in chloroform(1:4). A 2% aqueous solution has a pH of 5.5. It is similar in activity to tripelennamine but is claimed to be lesstoxic. The usual dose is 50 mg taken up to 4 times daily. Itis available in certain combination products.
General Description
White crystalline powder with a faint odor . pH: 5.1-5.7 (2 % aqueous solution).
Air & Water Reactions
Water soluble.
Reactivity Profile
thonzylamine hydrochloride behaves as a weak organic acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
Health Hazard
SYMPTOMS: Symptoms of exposure to thonzylamine hydrochloride may include drowsiness, lethargy, fatigue, hypnosis, coma, vertigo, ataxia, tinnitus, blurred vision, tremors, anxiety, insomnia, excitement, hallucinations, delirium, convulsions, dry mouth, anorexia, nausea, vomiting, abdominal distress, constipation, diarrhea, central nervous system depression, gastrointestinal reactions, respiratory arrest and circulatory collapse.
Fire Hazard
Flash point data for thonzylamine hydrochloride are not available. thonzylamine hydrochloride is probably combustible.
thonzylamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from thonzylamine hydrochloride manufacturers
- Product
- Thonzylamine hydrochloride 63-56-9
- Price
- US $1.00/kg
- Min. Order
- 100kg
- Purity
- 99%
- Supply Ability
- 1000000
- Release date
- 2024-01-05
- Product
- thonzylamine hydrochloride 63-56-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons
- Release date
- 2022-02-11