ChemicalBook > CAS DataBase List > cephaeline

cephaeline

Product Name: cephaeline
CAS No.: 483-17-0
Chemical Name: cephaeline
Synonyms: Cefalin;Cepheline;Aids002677;cephaeline;Alangine B;Aids-002677;Cephaelinel;(-)-Cephaelin;Desmethylemetine;Dihydropsychotrine
CBNumber: CB6904960
Molecular Formula: C28H38N2O4
Formula Weight: 466.61
MOL File: 483-17-0.mol

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cephaeline Property

Melting point:: 115-1160C
alpha: D20 -43.4° (c = 2 in chloroform)
Boiling point:: 569.42°C (rough estimate)
Density: 1.21±0.1 g/cm3 (20 ºC 760 Torr)
refractive index: 1.5800 (estimate)
storage temp.: -20°C Freezer
solubility: Acetonitrile: slightly soluble; Chloroform: slightly soluble; Ethanol: slightly soluble; Methanol: slightly soluble
form: A crystalline solid
pka: 9.90±0.40(Predicted)
color: Light yellow to yellow
Stability:: Hygroscopic

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Safety

RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20916
Product name: Cephaeline
Purity: ≥95%
Packaging: 500μg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 20916
Product name: Cephaeline
Purity: ≥95%
Packaging: 1mg
Price: $176
Updated: 2024/03/01

TRC

Product number: C256700
Product name: Cephaeline
Packaging: 2.5mg
Price: $270
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC19891
Product name: Cephaeline
Packaging: 1mg
Price: $225
Updated: 2021/12/16

ChemScene

Product number: CS-0032129
Product name: Cephaeline
Purity: >98.0%
Packaging: 1mg
Price: $230
Updated: 2021/12/16

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cephaeline Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

Cephaeline occurs in the ground roots ofipecac along with emetine. The Brazilian variety usually contains about 0.5%cephaeline. It is used as an emetic and anti amebic reagent.

Uses

Has been used as an emetic and expectorant

Definition

ChEBI: A pyridoisoquinoline comprising emetam having a hydroxy group at the 6'-position and methoxy substituents at the 7'-, 10- and 11-positions.

Health Hazard

The toxicity of cephaeline is lower than thatof emetine. The toxic effects are cumula tive. Ingestion of high doses may producehypotension, muscle weakness, and gastroin testinal problems, including nausea, vomiting, and diarrhea.

in vivo

Cephaeline (2 mg/kg, i.p.,daily for 3 days) suppresses ZIKV load and decreases the NS1 protein and ZIKV RNA in serum of ZIKV infected Ifnar1^?/? mice^[2].
Cephaeline (5 mg/kg, i.p.,daily for 7 days) effectively suppressed EBOV infection in EBOV mouse models^[3].
Cephaeline (5, 10 mg/kg, i.p., a single dose for 12 days) plays an anti-lung cancer role by inducing ferroptosis in tumor xenograft mouse model^[4].

Animal Model:	Ifnar1^?/? mice infected with ZIKV (8-9 week old, male and female)^[2]
Dosage:	2 mg/kg
Administration:	i.p.,daily for 3 days
Result:	Significantly lowered the serum viral load of ZIKV infected Ifnar1^?/? mice and decreased the NS1 protein and ZIKV RNA in serum and liver of mice, respectively.

Animal Model:	EBOV mouse model^[3]
Dosage:	5 mg/kg
Administration:	i.p., daily for 7 days
Result:	Achieved 67% survival in EBOV infection to death in EBOV mouse model.

Animal Model:	Tumor xenograft mouse model injected with the lung cancer H460 cell line^[4]
Dosage:	5, 10 mg/kg
Administration:	i.p., a single dose for 12 days
Result:	Showed significant antitumour effects in tumor xenograft mouse model.

IC 50

EBOV

cephaeline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from cephaeline manufacturers

Career Henan Chemical Co

Product: cephaeline 483-17-0
Price: US $2.00/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2019-12-27

483-17-0, cephaelineRelated Search:

MINIMALE LIEFERMENGE L-Hyoscyamine Xanthiazone menisdaurin daurisoline ISOEMETINE HYDROBROMIDE VERATRIDINE EMETINE HCL Cevadine veratramine Xanthiside EMETINE HYDROBROMIDE CEPHAELINE HYDROCHLORIDE Emetine Cephaeline dihydrochloride methylpsychotrine CEPHAELINE DIHYDROCHLORIDE N X 2 HCL CEPHAELINE HYDROBROMIDE (200 MG)

cephaeline

O-Phosphatidyl-ethanolamine

Cefalin

(-)-Cephaelin

(1R)-1-[[(2S,3R,11bS)-3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-2-yl]methyl]-1,2,3,4-tetrahydro-7-methoxy-6-isoquinolinol

7',10,11-Trimethoxyemetan-6'-ol

Cepheline

Desmethylemetine

Dihydropsychotrine

5853-29-2 (Dihydrochloride)

Aids002677

Aids-002677

Cephaelinel

Isoquinoline alkaloid

Nsc32944 (dihydrochloride)

Alangine B

6-Isoquinolinol, 1-[[(2S,3R,11bS)-3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-2-yl]methyl]-1,2,3,4-tetrahydro-7-methoxy-, (1R)-

cephaeline USP/EP/BP

NSC 32944,inhibit,Inhibitor,NSC32944,Ebola,Cephaeline,Filovirus,phenolic,alkaloid,virus,Influenza Virus,NSC-32944,Zika

483-17-0

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