2-bromo-4-(trifluoromethyl)benzoic acid
- Product Name
- 2-bromo-4-(trifluoromethyl)benzoic acid
- CAS No.
- 328-89-2
- Chemical Name
- 2-bromo-4-(trifluoromethyl)benzoic acid
- Synonyms
- 3-Bromo-4-carboxybenzotrifluoride;2-BroM-4-trifluorMethyl-benzoesaeure;2-bromo-4-(trifluoromethyl)benzoicaci;2-Bromo-4-(trifluoromethl)benzoic acid;2-bromo-4-(trifluoromethyl)benzoic acid;Benzoic acid,2-broMo-4-(trifluoroMethyl)-;2-Bromo-4-(trifluoromethyl)benzoicacid,98%;2-Bromo-4-(trifluoromethyl)benzoic acid 97+%
- CBNumber
- CB6916482
- Molecular Formula
- C8H4BrF3O2
- Formula Weight
- 269.02
- MOL File
- 328-89-2.mol
2-bromo-4-(trifluoromethyl)benzoic acid Property
- Melting point:
- 114.0 to 118.0 °C
- Boiling point:
- 271.9±40.0 °C(Predicted)
- Density
- 1.773±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 2.34±0.10(Predicted)
- color
- White to Orange to Green
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B5334
- Product name
- 2-Bromo-4-(trifluoromethyl)benzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $50
- Updated
- 2025/07/31
- Product number
- B5334
- Product name
- 2-Bromo-4-(trifluoromethyl)benzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $247
- Updated
- 2025/07/31
- Product number
- B695453
- Product name
- 2-Bromo-4-(trifluoromethyl)benzoic Acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB106069
- Product name
- 2-Bromo-4-(trifluoromethyl)benzoic acid
- Packaging
- 2g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- J50573
- Product name
- 2-Bromo-4-(trifluoromethyl)benzoic Acid
- Packaging
- 10g
- Price
- $100
- Updated
- 2021/12/16
2-bromo-4-(trifluoromethyl)benzoic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Synthesis
402-13-1
328-89-2
Example 5 Synthesis of 2-bromo-4-(trifluoromethyl)benzoic acid (Formula V, where R1 = H, R2 = CF3): 205 g (1 mol) of 2-amino-4-trifluoromethylbenzoic acid, 600 ml of glacial acetic acid, and 400 ml of 47% hydrobromic acid were added sequentially to a 3 liter round bottom flask. After the ingredients were completely dissolved, the reaction mixture was cooled to -10°C and diluted with 400 ml of water. Subsequently, a solution of 69 g (1 mol) of sodium nitrite dissolved in 200 ml of water was added dropwise while keeping the temperature below 0°C. After the dropwise addition, the reaction mixture was continued to be stirred at 0°C for 2 hours. The above solution was slowly added dropwise to a 6-liter reactor pre-filled with 143.5 g (1 mol) of cuprous bromide dissolved in 500 ml of 47% hydrobromic acid and maintained at 60°C. After completion of dropwise addition, the reaction mixture was stirred at 60 °C for 1 h, then cooled to room temperature and poured into two liters of ice water. The precipitated solid was filtered through a sintered glass funnel, washed with water, and dried under a stream of air to give 216 g (yield: 80%) of 2-bromo-4-(trifluoromethyl)benzoic acid as a solid with a melting point of 118.5 °C. Note: See the literature for the preparation of 2-amino-4-(trifluoromethyl)benzoic acid (formula VI, where R1 = H and R2 = CF3).
References
[1] Patent: US5514719, 1996, A
[2] Synthesis (Germany), 2012, vol. 44, # 14, p. 2173 - 2180
[3] Patent: WO2005/54176, 2005, A1. Location in patent: Page/Page column 62
2-bromo-4-(trifluoromethyl)benzoic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-bromo-4-(trifluoromethyl)benzoic acid manufacturers
- Product
- 2-bromo-4-(trifluoromethyl)benzoic acid 328-89-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11