2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE
Uses- Product Name
- 2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE
- CAS No.
- 66417-30-9
- Chemical Name
- 2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE
- Synonyms
- 3-BROMO-4-METHYLBENZOTRIFLUORIDE;2-Bromo-4-(trifluoromethyl)toluene;5-BROMO-2-METHYLBENZOTRIFLUORIDE, 97+%;2-Methyl-5-(trifluoroMethyl)broMobenzen;2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE;Benzene, 2-bromo-1-methyl-4-(trifluoromethyl)-
- CBNumber
- CB8249650
- Molecular Formula
- C8H6BrF3
- Formula Weight
- 239.03
- MOL File
- 66417-30-9.mol
2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE Property
- Boiling point:
- 183.0±35.0 °C(Predicted)
- Density
- 1.538±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- liquid
- color
- Clear, colourless
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- HCH0004389
- Product name
- 3-BROMO-4-METHYL BENZOTRIFLUORIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $610.97
- Updated
- 2021/12/16
- Product number
- HCH0004389
- Product name
- 3-BROMO-4-METHYL BENZOTRIFLUORIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $845.34
- Updated
- 2021/12/16
- Product number
- FB32868
- Product name
- 2-Bromo-1-methyl-4-(trifluoromethyl)benzene
- Packaging
- 10g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FB32868
- Product name
- 2-Bromo-1-methyl-4-(trifluoromethyl)benzene
- Packaging
- 25g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- FB32868
- Product name
- 2-Bromo-1-methyl-4-(trifluoromethyl)benzene
- Packaging
- 5G
- Price
- $130
- Updated
- 2021/12/16
2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE Chemical Properties,Usage,Production
Uses
3-Bromo-4-methyltrifluorotoluene is an aromatic hydrocarbon derivative that can be used as an organic intermediate.
Synthesis
6140-17-6
66417-30-9
To 4-(trifluoromethyl)toluene (22b, 9.0 g, 56 mmol), 20 ml of trifluoroacetic acid (TFA) and 5.6 ml of 28% sulfuric acid (H2SO4) were added to a round bottom flask. N-bromosuccinimide (NBS, 10.0 g, 56 mmol, 1 equiv) was added to the reaction mixture in batches. The reaction was stirred overnight at room temperature.After 20 h, post-treatment was performed: the reaction mixture was poured into 100 ml of ice water and the organic layer (oily residue) was separated from the aqueous layer by extraction with ether (Et2O). The ether layers were combined, dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to remove the solvent. The pure product 3-bromo-4-methylbenzotrifluoride (7.86 g, yield 59%) was obtained as a light yellow oil. Structural confirmation: The product was analyzed by RP-HPLC under the following conditions: HP 1100 HPLC system, Waters 3.9×150 mm NovaPak HR C18 guard column, injection volume of 0.010 mL, flow rate of 1.5 mL/min, injection loop of 1.500 mL, detection wavelength of 254 nm, mobile phase A was water (containing 0.1% v/v TFA). Mobile phase B was acetonitrile (containing 0.1% v/v TFA), gradient program: initial 10% B held for 1 min, linear increase to 80% B in 1-10 min, linear increase to 100% B in 10-11 min, held for 1 min. Product retention time was 11.7 min.1H NMR (400 MHz, CDCl3): δ 2.45 (s, 3H), 7.34 (d, J=8.0 Hz, 1H), 7.50 (d, J=8.0 Hz, 1H), 7.80 (s, 1H).
References
[1] Patent: WO2008/66921, 2008, A2. Location in patent: Page/Page column 69-70
[2] Journal of Organic Chemistry, 1978, vol. 43, p. 2941 - 2946
2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE manufacturers
- Product
- 2-Bromo-1-methyl-4-(trifluoromethyl)benzene 66417-30-9
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 100KG
- Release date
- 2025-08-20
- Product
- 2-Methyl-5-(trifluoroMethyl)broMobenzen 66417-30-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-13
- Product
- 2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE 66417-30-9
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 97%
- Supply Ability
- 2000KG
- Release date
- 2023-07-12