4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZENE

Product Name: 4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZENE
CAS No.: 86845-27-4
Chemical Name: 4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZENE
Synonyms: 5-BROMO-2-METHYLBENZOTRIFLUORIDE;4-BROMO-2-(TRIFLUOROMETHYL)TOLUENE;5-Bromo-2-methylbenzotrifluoride98%;5-Bromo-2-methylbenzotrifluoride 98%;4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZEN;4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZENE;4-bromo-1-methyl-2-(trifluoromethyl)benzene;Benzene,4-broMo-1-Methyl-2-(trifluoroMethyl)-;4-Methyl-3-(trifluoromethyl)bromobenzene, 97+%;4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZENE86845-27-4
CBNumber: CB6190972
Molecular Formula: C8H6BrF3
Formula Weight: 239.03
MOL File: 86845-27-4.mol

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4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZENE Property

Boiling point:: 181.8±35.0 °C(Predicted)
Density: 1 g/cm³
refractive index: 1.4870
storage temp.: 2-8°C
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C8H6BrF3/c1-5-2-3-6(9)4-7(5)8(10,11)12/h2-4H,1H3
InChIKey: IZFVIEYHUOUPPH-UHFFFAOYSA-N
SMILES: C1(C)=CC=C(Br)C=C1C(F)(F)F
CAS DataBase Reference: 86845-27-4(CAS DataBase Reference)

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Safety

Hazard Codes: F
Risk Statements: 10-36/37/38
Safety Statements: 16-26-36
RIDADR: 1993
Hazard Note: Flammable
HazardClass: IRRITANT
PackingGroup: III
HS Code: 2903998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B699063
Product name: 4-Bromo-2-(trifluoromethyl)toluene
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B699063
Product name: 4-Bromo-2-(trifluoromethyl)toluene
Packaging: 250mg
Price: $55
Updated: 2021/12/16

BroadPharm

Product number: BP-20386
Product name: 4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZENE
Purity: 96%
Packaging: 1g
Price: $20
Updated: 2021/12/16

Matrix Scientific

Product number: 054612
Product name: 5-Bromo-2-methylbenzotrifluoride
Purity: 98%
Packaging: 5g
Price: $38
Updated: 2021/12/16

SynQuest Laboratories

Product number: 1800-B-59
Product name: 5-Bromo-2-methylbenzotrifluoride
Purity: 98%
Packaging: 1g
Price: $68
Updated: 2021/12/16

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4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZENE Chemical Properties,Usage,Production

Synthesis

65934-74-9

86845-27-4

Under nitrogen protection, 2642.3 g of a 48% aqueous solution of hydrogen bromide was added to the reactor. The temperature of the system was adjusted to 30 °C, followed by the slow dropwise addition of 1760.0 g of a mixed solution of water and 880.0 g of acetic acid while stirring. Next, 880.0 g of 2-methyl-5-aminobenzotrifluoride (isomer content 0.037%, determined by gas phase area normalization) was added. After the dropwise addition, the reaction temperature was raised to 95 °C with continuous stirring for 30 min to obtain the corresponding hydrogen bromide salt solution. The reaction solution was cooled to 0 °C, at which temperature 1213.3 g of a 30% aqueous sodium nitrite solution was slowly added dropwise. After completion of the dropwise addition, the reaction was continued for 1.0 hour to ensure complete reaction. The prepared diazonium salt solution was slowly added dropwise at 65 °C to a pre-prepared mixture containing 360.4 g of copper bromide and 4997.0 g of 48% aqueous hydrogen bromide. A large amount of nitrogen release was observed during the reaction. After dropwise addition, stirring was continued for 1 hour to obtain a solution of 4-bromo-1-methyl-2-(trifluoromethyl)benzene. At the end of the reaction, the reaction solution was cooled to 20 °C, stirred for 1.0 h and left to stratify. 1046.0 g of the organic layer was separated and 3661.0 g of water was added and the pH was adjusted with 5.0% alkali metal hydroxide solution to 7. Subsequent steam distillation afforded 1032.0 g of a pale yellow 4-bromo-1-methyl-2-(trifluoromethyl)benzene product in 85.9% yield and 99.2% gas phase purity. Gas chromatographic analysis showed that the isomer content in the product was less than 0.1%.

References

[1] Patent: CN107915570, 2018, A. Location in patent: Paragraph 0057-0061; 0064-0067

4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZENE Suppliers

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View Lastest Price from 4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZENE manufacturers

Career Henan Chemical Co

Product: 4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZENE 86845-27-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: kg/T
Release date: 2019-12-18

86845-27-4, 4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZENERelated Search:

2-Methylbenzotrifluoride Toluene 2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE 2-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZENE 4-Methyl-2-(trifluoromethyl)bromobenzene, 97+% 3-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE 2-Methyl-5-(trifluoromethyl)bromobenzene, 97+% 4-METHYL-2-(TRIFLUOROMETHYL)BROMOBENZENE

4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZENE

4-BROMO-2-(TRIFLUOROMETHYL)TOLUENE

5-BROMO-2-METHYLBENZOTRIFLUORIDE

4-Methyl-3-(trifluoromethyl)bromobenzene, 97+%

5-Bromo-2-methylbenzotrifluoride 98%

5-Bromo-2-methylbenzotrifluoride98%

4-bromo-1-methyl-2-(trifluoromethyl)benzene

4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZENE86845-27-4

Benzene,4-broMo-1-Methyl-2-(trifluoroMethyl)-

4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZEN

86845-27-4

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