ChemicalBook > CAS DataBase List > 2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE

2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE

Uses

Product Name: 2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE
CAS No.: 66417-30-9
Chemical Name: 2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE
Synonyms: 3-BROMO-4-METHYLBENZOTRIFLUORIDE;2-Bromo-4-(trifluoromethyl)toluene;5-BROMO-2-METHYLBENZOTRIFLUORIDE, 97+%;2-Methyl-5-(trifluoroMethyl)broMobenzen;2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE;Benzene, 2-bromo-1-methyl-4-(trifluoromethyl)-
CBNumber: CB8249650
Molecular Formula: C8H6BrF3
Formula Weight: 239.03
MOL File: 66417-30-9.mol

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2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE Property

Boiling point:: 183.0±35.0 °C(Predicted)
Density: 1.538±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: liquid
color: Clear, colourless

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Safety

Hazard Codes: F,Xn
Risk Statements: 22
Hazard Note: Flammable
HazardClass: IRRITANT
HS Code: 2903998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0004389
Product name: 3-BROMO-4-METHYL BENZOTRIFLUORIDE
Purity: 95.00%
Packaging: 1G
Price: $610.97
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0004389
Product name: 3-BROMO-4-METHYL BENZOTRIFLUORIDE
Purity: 95.00%
Packaging: 5G
Price: $845.34
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB32868
Product name: 2-Bromo-1-methyl-4-(trifluoromethyl)benzene
Packaging: 10g
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB32868
Product name: 2-Bromo-1-methyl-4-(trifluoromethyl)benzene
Packaging: 25g
Price: $400
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB32868
Product name: 2-Bromo-1-methyl-4-(trifluoromethyl)benzene
Packaging: 5G
Price: $130
Updated: 2021/12/16

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2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE Chemical Properties,Usage,Production

Uses

3-Bromo-4-methyltrifluorotoluene is an aromatic hydrocarbon derivative that can be used as an organic intermediate.

Synthesis

6140-17-6

66417-30-9

To 4-(trifluoromethyl)toluene (22b, 9.0 g, 56 mmol), 20 ml of trifluoroacetic acid (TFA) and 5.6 ml of 28% sulfuric acid (H2SO4) were added to a round bottom flask. N-bromosuccinimide (NBS, 10.0 g, 56 mmol, 1 equiv) was added to the reaction mixture in batches. The reaction was stirred overnight at room temperature.After 20 h, post-treatment was performed: the reaction mixture was poured into 100 ml of ice water and the organic layer (oily residue) was separated from the aqueous layer by extraction with ether (Et2O). The ether layers were combined, dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to remove the solvent. The pure product 3-bromo-4-methylbenzotrifluoride (7.86 g, yield 59%) was obtained as a light yellow oil. Structural confirmation: The product was analyzed by RP-HPLC under the following conditions: HP 1100 HPLC system, Waters 3.9×150 mm NovaPak HR C18 guard column, injection volume of 0.010 mL, flow rate of 1.5 mL/min, injection loop of 1.500 mL, detection wavelength of 254 nm, mobile phase A was water (containing 0.1% v/v TFA). Mobile phase B was acetonitrile (containing 0.1% v/v TFA), gradient program: initial 10% B held for 1 min, linear increase to 80% B in 1-10 min, linear increase to 100% B in 10-11 min, held for 1 min. Product retention time was 11.7 min.1H NMR (400 MHz, CDCl3): δ 2.45 (s, 3H), 7.34 (d, J=8.0 Hz, 1H), 7.50 (d, J=8.0 Hz, 1H), 7.80 (s, 1H).

References

[1] Patent: WO2008/66921, 2008, A2. Location in patent: Page/Page column 69-70
[2] Journal of Organic Chemistry, 1978, vol. 43, p. 2941 - 2946

2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-Bromo-1-methyl-4-(trifluoromethyl)benzene 66417-30-9
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 100KG
Release date: 2025-08-20

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Methyl-5-(trifluoroMethyl)broMobenzen 66417-30-9
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-13

Hangzhou ICH Biofarm Co., Ltd

Product: 2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE 66417-30-9
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 97%
Supply Ability: 2000KG
Release date: 2023-07-12

66417-30-9, 2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENERelated Search:

4-BROMO-2-(TRIFLUOROMETHYL)BENZONITRILE 2-Bromo-4-(trifluoromethyl)phenylacetonitrile 2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE 2,5-Bis(trifluoromethyl)bromobenzene 2-BROMO-4-(TRIFLUOROMETHYL)BENZONITRILE 2-BROMO-4-(TRIFLUOROMETHYL)BENZYL ALCOHOL 2-bromo-4-(trifluoromethyl)benzoic acid 2-Methyl-3-(trifluoromethyl)bromobenzene 4-METHYL-3-(TRIFLUOROMETHYL)BROMOBENZENE,4-Methyl-3-(trifluoromethyl)bromobenzene, 97+% 4-METHYL-2-(TRIFLUOROMETHYL)BROMOBENZENE 4-Methylbenzotrifluoride 2-BROMO-4-(TRIFLUORMETHYL)PHENYLACETIC ACID 3-BROMO-2-METHYL-5-TRIFLUOROMETHYLANILIN 1-BROMO-2-NITRO-4,5-DI(TRIFLUOROMETHYL)BENZENE 2-bromo-4-(trifluoromethyl)benzaldehyde 2-BROMO-4-(TRIFLUOROMETHYL)BENZYL CHLORIDE 2-BROMO-6-NITRO-4-TRIFLUOROMETHYLTOLUENE 2-BROMO-4,5-DI(TRIFLUOROMETHYL)ANILINE

3-BROMO-4-METHYLBENZOTRIFLUORIDE

2-METHYL-5-(TRIFLUOROMETHYL)BROMOBENZENE

2-Methyl-5-(trifluoroMethyl)broMobenzen

2-Bromo-4-(trifluoromethyl)toluene

5-BROMO-2-METHYLBENZOTRIFLUORIDE, 97+%

Benzene, 2-bromo-1-methyl-4-(trifluoromethyl)-

66417-30-9