oxametacin
- Product Name
- oxametacin
- CAS No.
- 27035-30-9
- Chemical Name
- oxametacin
- Synonyms
- Flogar;ABC-8/3;oxametacin;Oxametacine;oxamethacin;Indoxamic acid;1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetohydroxamic acid;1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetohydroxamic acid;1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-N-hydroxy-5-methoxy-2-methyl-;2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]-N-hydroxy-acetamide
- CBNumber
- CB6939025
- Molecular Formula
- C19H17ClN2O4
- Formula Weight
- 372.806
- MOL File
- 27035-30-9.mol
oxametacin Property
- Melting point:
- 181-182° (dec)
- Density
- 1.2671 (rough estimate)
- refractive index
- 1.6800 (estimate)
- solubility
- DMSO (Slightly), Methanol (Heated, Slightly)
- form
- Solid
- pka
- 9.00±0.20(Predicted)
- color
- Crystals from dioxane
Safety
- Toxicity
- LD50 orally in rats: 96 mg/kg (De Martiis, U.S. patent)
N-Bromosuccinimide Price
- Product number
- O840000
- Product name
- Oxametacin
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- O840000
- Product name
- Oxametacin
- Packaging
- 2.5g
- Price
- $1190
- Updated
- 2021/12/16
- Product number
- HCH0124767
- Product name
- 2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-N-HYDROXYACETAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.23
- Updated
- 2021/12/16
- Product number
- 48033
- Product name
- Oxametacin
- Packaging
- 250mg
- Price
- $650
- Updated
- 2021/12/16
oxametacin Chemical Properties,Usage,Production
Description
Oxametacine is prepared by the acylation of hydroxylamine with indomethacin acid chloride. Oxametacine at a dose of 100 mg is reported to be as effective as 50 mg of indomethacin in reducing pain and inflammation with a lower incidence of adverse effects.
Originator
Flogar, A.B.C. , Italy ,1976
Uses
Oxametacin is a non-steroidal anti-inflammatory drug.
Definition
ChEBI: A hydroxamic acid obtained by formal condensation of the carboxy group of indometacin with the amino group of hydroxylamine.
Manufacturing Process
1 g of 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indoleacetic acid [J. Am. Chem. Soc. 85, 488-489 (1963)] is treated in a nitrogen stream with 10 ml thionyl chloride in which it promptly dissolves. The solution is quickly evaporated in vacuum and the residue (which typically is of a deep browngreen color) is distempered, twice or three times, with a few ml anhydrous benzene which is removed in vacuum each time. The resulting residue is thoroughly distempered with 5 ml anhydrous ether which dissolves most of the color impurities, and separated by filtering, purified by crystallizing from plenty of anhydrous ether, yielding a crystalline mass of needles of strawyellow color, melting point 124°C to 127°C. Yield: 0.700 g. Found: Cl % 18.62 (calculated 18.84).
The product is relatively stable towards water and aqueous alkalies in which it proves to be insoluble even after dwelling therein several hours at room temperature. It reacts, better if at elevated temperature, with lower alcohols with which it forms the corresponding esters, and with ammonia under suitable conditions for forming the amide (melting point 219°C to 221°C).
A solution of 1.330 g sodium hydroxide in 20 ml water is slowly admixed with 2.330 g hydroxylamine hydrochloride while cooling, whereupon 1 g chloride of 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indoleacetic acid is distempered in this neutral or slightly alkaline solution by vigorously stirring during a few minutes.
The acid chloride reacts with the free hydroxylamine with considerable rapidity apparently without dissolving. The reaction is completed when a sample of the suspension shows to become clear on adding aqueous alkali. The crystalline pale-yellow mass of product is separated by filtering, lavishly washed with water and dried in vacuum. The crude product yield is actually quantitative. The product is purified with excellent yields by repeatedly crystallizing from hot dioxane and washing with ether: melting point 181°C to 182°C (dec.).
Therapeutic Function
Antiinflammatory
Trade name
Flogar (UCB, Belgium; ABC, Portugal).
Safety Profile
Poison by ingestion and intraperitoneal routes. An anti-inflammatory agent. When heated to decomposition it emits toxic fumes of Clí and NOx.
oxametacin Preparation Products And Raw materials
Raw materials
Preparation Products
oxametacin Suppliers
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 15002134094
- marketing@targetmol.cn
- Country
- China
- ProdList
- 19707
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@lanospharma.com
- Country
- China
- ProdList
- 6329
- Advantage
- 56
- Tel
- --
- Fax
- --
- zhou@pharmchemical.com
- Country
- China
- ProdList
- 2748
- Advantage
- 60