CGP 57380
- Product Name
- CGP 57380
- CAS No.
- 522629-08-9
- Chemical Name
- CGP 57380
- Synonyms
- P 57380;CS-1420;CGP 57380;C P 57380;MNK1 Inhibitor;CGP57380; CGP-57380;MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem;N3-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine;3-N-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine;1H-Pyrazolo[3,4-d]pyrimidine-3,4-diamine, N3-(4-fluorophenyl)-
- CBNumber
- CB6972321
- Molecular Formula
- C11H9FN6
- Formula Weight
- 244.23
- MOL File
- 522629-08-9.mol
CGP 57380 Property
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- form
- powder
- color
- white to beige
Safety
- WGK Germany
- 3
- HS Code
- 2933599590
N-Bromosuccinimide Price
- Product number
- C0993
- Product name
- CGP 57380
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $258
- Updated
- 2024/03/01
- Product number
- 454861
- Product name
- MNK1 Inhibitor
- Packaging
- 5mg
- Price
- $303
- Updated
- 2024/03/01
- Product number
- 13322
- Product name
- CGP 57380
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 13322
- Product name
- CGP 57380
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- C0993
- Product name
- CGP 57380
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $999
- Updated
- 2023/06/20
CGP 57380 Chemical Properties,Usage,Production
Uses
CGP 57380 has been used:
- as a mitogen-activated protein kinase-interacting kinase 1 (MNK1) inhibitor to investigate the role of Mnk1 on eukaryotic translation initiation factor 4F (eIF4F) assembly and Newcastle disease virus (NDV) replication in HeLa cells
- as an MNK1 inhibitor to block eIF4 complex to evaluate the contribution of interferon (IFN-γ) translation during m157- transgenic (Tg) stimulation
- as a β-catenin nuclear translocation inhibitor to analyze its effects on cytoplasmic and nuclear fractions of cells
Definition
ChEBI: N3-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine is a pyrazolopyrimidine.
Biological Activity
Inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC 50 = 2.2 μ M) that displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases. Blocks phosphorylation of eIF4E in cellular assays (IC 50 = 3 μ M) and inhibits LPS-induced TNF α expression in macrophages.
Biochem/physiol Actions
CGP 57380 is a β-catenin nuclear translocation inhibitor, which prevents the proliferation of several?cancers. It enhances radiation-induced apoptosis in nasopharyngeal carcinoma (NPC). CGP 57380 upregulates β-catenin in the cytoplasm and inhibits epithelial-mesenchymal transition (EMT).
storage
Store at +4°C
References
[1]. knauf u, tschopp c, gram h. negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. mol cell biol, 2001, 21(16): 5500-5511.
[2]. ishida m, ishida t, nakashima h, et al. mnk1 is required for angiotensin ii-induced protein synthesis in vascular smooth muscle cells. circ res, 2003, 93(12): 1218-1224.
[3]. andersson k, sundler r. posttranscriptional regulation of tnfalpha expression via eukaryotic initiation factor 4e (eif4e) phosphorylation in mouse macrophages. cytokine, 2006, 33(1): 52-57.
[4]. rowlett rm, chrestensen ca, nyce m, et al. mnk kinases regulate multiple tlr pathways and innate proinflammatory cytokines in macrophages. am j physiol gastrointest liver physiol, 2008, 294(2): g452-459.
CGP 57380 Preparation Products And Raw materials
Raw materials
Preparation Products
CGP 57380 Suppliers
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View Lastest Price from CGP 57380 manufacturers
- Product
- CGP 57380 522629-08-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-25