ChemicalBook > CAS DataBase List > CGP 57380

CGP 57380

Product Name
CGP 57380
CAS No.
522629-08-9
Chemical Name
CGP 57380
Synonyms
P 57380;CS-1420;CGP 57380;MNK1 Inhibitor;CGP57380; CGP-57380;MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem;N3-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine;3-N-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine;1H-Pyrazolo[3,4-d]pyrimidine-3,4-diamine, N3-(4-fluorophenyl)-;CGP57380, N3-(4-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine
CBNumber
CB6972321
Molecular Formula
C11H9FN6
Formula Weight
244.23
MOL File
522629-08-9.mol
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CGP 57380 Property

storage temp. 
2-8°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C0993
Product name
CGP 57380
Purity
≥98% (HPLC)
Packaging
5mg
Price
$258
Updated
2024/03/01
Sigma-Aldrich
Product number
454861
Product name
MNK1 Inhibitor
Packaging
5mg
Price
$303
Updated
2024/03/01
Cayman Chemical
Product number
13322
Product name
CGP 57380
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
13322
Product name
CGP 57380
Purity
≥95%
Packaging
5mg
Price
$109
Updated
2024/03/01
Sigma-Aldrich
Product number
C0993
Product name
CGP 57380
Purity
≥98% (HPLC)
Packaging
25mg
Price
$999
Updated
2023/06/20
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CGP 57380 Chemical Properties,Usage,Production

Uses

CGP 57380 has been used:

  • as a mitogen-activated protein kinase-interacting kinase 1 (MNK1) inhibitor to investigate the role of Mnk1 on eukaryotic translation initiation factor 4F (eIF4F) assembly and Newcastle disease virus (NDV) replication in HeLa cells
  • as an MNK1 inhibitor to block eIF4 complex to evaluate the contribution of interferon (IFN-γ) translation during m157- transgenic (Tg) stimulation
  • as a β-catenin nuclear translocation inhibitor to analyze its effects on cytoplasmic and nuclear fractions of cells

Definition

ChEBI: N3-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine is a pyrazolopyrimidine.

Biological Activity

Inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC 50 = 2.2 μ M) that displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases. Blocks phosphorylation of eIF4E in cellular assays (IC 50 = 3 μ M) and inhibits LPS-induced TNF α expression in macrophages.

Biochem/physiol Actions

CGP 57380 is a β-catenin nuclear translocation inhibitor, which prevents the proliferation of several?cancers. It enhances radiation-induced apoptosis in nasopharyngeal carcinoma (NPC). CGP 57380 upregulates β-catenin in the cytoplasm and inhibits epithelial-mesenchymal transition (EMT).

storage

Store at +4°C

References

[1]. knauf u, tschopp c, gram h. negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. mol cell biol, 2001, 21(16): 5500-5511.
[2]. ishida m, ishida t, nakashima h, et al. mnk1 is required for angiotensin ii-induced protein synthesis in vascular smooth muscle cells. circ res, 2003, 93(12): 1218-1224.
[3]. andersson k, sundler r. posttranscriptional regulation of tnfalpha expression via eukaryotic initiation factor 4e (eif4e) phosphorylation in mouse macrophages. cytokine, 2006, 33(1): 52-57.
[4]. rowlett rm, chrestensen ca, nyce m, et al. mnk kinases regulate multiple tlr pathways and innate proinflammatory cytokines in macrophages. am j physiol gastrointest liver physiol, 2008, 294(2): g452-459.

CGP 57380 Preparation Products And Raw materials

Raw materials

Preparation Products

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CGP 57380 Suppliers

China 62 India 2 Switzerland 1 United Kingdom 1 United States 15 Global 81
3B Pharmachem (Wuhan) International Co.,Ltd.
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View Lastest Price from CGP 57380 manufacturers

Career Henan Chemical Co
Product
CGP 57380 522629-08-9
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-25

522629-08-9, CGP 57380Related Search:

1H-Benzotriazole Sorafenib tosylate Fludarabine Gemcitabine Vorinostat Erlotinib hydrochloride CGP 57380

  • CGP 57380
  • CGP57380, N3-(4-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine
  • MNK1 Inhibitor
  • N3-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
  • CGP57380; CGP-57380
  • CS-1420
  • MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem
  • P 57380
  • 1H-Pyrazolo[3,4-d]pyrimidine-3,4-diamine, N3-(4-fluorophenyl)-
  • 3-N-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
  • CGP-57380,CGP 57380,Mitogen activated protein kinase interacting kinase,Inhibitor,MAPK interacting kinase,inhibit,CGP57380,MNK,Apoptosis,MAP kinase interacting kinase
  • 522629-08-9
  • C11H9FN6
  • Inhibitors