CGP 57380

ChemicalBook > CAS DataBase List > CGP 57380

Product Name: CGP 57380
CAS No.: 522629-08-9
Chemical Name: CGP 57380
Synonyms: P 57380;CS-1420;CGP 57380;C P 57380;MNK1 Inhibitor;CGP57380; CGP-57380;CGP 57380, MNK inhibitor;CGP 57380, 10 mM in DMSO;MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem;N3-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
CBNumber: CB6972321
Molecular Formula: C11H9FN6
Formula Weight: 244.23
MOL File: 522629-08-9.mol

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CGP 57380 Property

storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
color: white to beige

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Safety

WGK Germany: 3
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C0993
Product name: CGP 57380
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $258
Updated: 2024/03/01

Sigma-Aldrich

Product number: 454861
Product name: MNK1 Inhibitor
Packaging: 5mg
Price: $303
Updated: 2024/03/01

Cayman Chemical

Product number: 13322
Product name: CGP 57380
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 13322
Product name: CGP 57380
Purity: ≥95%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Sigma-Aldrich

Product number: C0993
Product name: CGP 57380
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $999
Updated: 2023/06/20

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CGP 57380 Chemical Properties,Usage,Production

Uses

CGP 57380 has been used:

as a mitogen-activated protein kinase-interacting kinase 1 (MNK1) inhibitor to investigate the role of Mnk1 on eukaryotic translation initiation factor 4F (eIF4F) assembly and Newcastle disease virus (NDV) replication in HeLa cells
as an MNK1 inhibitor to block eIF4 complex to evaluate the contribution of interferon (IFN-γ) translation during m157- transgenic (Tg) stimulation
as a β-catenin nuclear translocation inhibitor to analyze its effects on cytoplasmic and nuclear fractions of cells

Definition

ChEBI: N3-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine is a pyrazolopyrimidine.

Biological Activity

Inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC 50 = 2.2 μ M) that displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases. Blocks phosphorylation of eIF4E in cellular assays (IC 50 = 3 μ M) and inhibits LPS-induced TNF α expression in macrophages.

Biochem/physiol Actions

CGP 57380 is a β-catenin nuclear translocation inhibitor, which prevents the proliferation of several?cancers. It enhances radiation-induced apoptosis in nasopharyngeal carcinoma (NPC). CGP 57380 upregulates β-catenin in the cytoplasm and inhibits epithelial-mesenchymal transition (EMT).

storage

Store at +4°C

References

[1]. knauf u, tschopp c, gram h. negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. mol cell biol, 2001, 21(16): 5500-5511.
[2]. ishida m, ishida t, nakashima h, et al. mnk1 is required for angiotensin ii-induced protein synthesis in vascular smooth muscle cells. circ res, 2003, 93(12): 1218-1224.
[3]. andersson k, sundler r. posttranscriptional regulation of tnfalpha expression via eukaryotic initiation factor 4e (eif4e) phosphorylation in mouse macrophages. cytokine, 2006, 33(1): 52-57.
[4]. rowlett rm, chrestensen ca, nyce m, et al. mnk kinases regulate multiple tlr pathways and innate proinflammatory cytokines in macrophages. am j physiol gastrointest liver physiol, 2008, 294(2): g452-459.

CGP 57380 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CGP 57380 manufacturers

Career Henan Chemical Co

Product: CGP 57380 522629-08-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

522629-08-9, CGP 57380Related Search:

1H-Benzotriazole Sorafenib tosylate Fludarabine Gemcitabine Vorinostat Erlotinib hydrochloride CGP 57380

CGP 57380

CGP57380, N3-(4-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine

MNK1 Inhibitor

N3-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine

CGP57380; CGP-57380

CS-1420

MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem

P 57380

1H-Pyrazolo[3,4-d]pyrimidine-3,4-diamine, N3-(4-fluorophenyl)-

3-N-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine

CGP-57380,CGP 57380,Mitogen activated protein kinase interacting kinase,Inhibitor,MAPK interacting kinase,inhibit,CGP57380,MNK,Apoptosis,MAP kinase interacting kinase

C P 57380

CGP 57380, MNK inhibitor

CGP 57380, 10 mM in DMSO

522629-08-9

C11H9FN6

Inhibitors