LEPTOMYCIN A
- Product Name
- LEPTOMYCIN A
- CAS No.
- 87081-36-5
- Chemical Name
- LEPTOMYCIN A
- Synonyms
- PD-118607;NSC 369326;Antibiotic PD-118607;Antibiotic ATS-1287A;LEPTOMYCIN A USP/EP/BP;QECBVZBMGUAZDL-DLWOFZAMSA-N;ATS 1287A, PD 118607, JildaMycin;19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid;19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid;2,10,12,16,18-Nonadecapentaenoicacid,19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-
- CBNumber
- CB6972730
- Molecular Formula
- C32H46O6
- Formula Weight
- 526.7
- MOL File
- 87081-36-5.mol
LEPTOMYCIN A Property
- Flash point:
- 9℃
- storage temp.
- -20°C
- solubility
- Ethanol: Soluble; Methanol: Soluble
- form
- methanol solution
Safety
- Hazard Codes
- F,T
- Risk Statements
- 11-23/24/25-39/23/24/25
- Safety Statements
- 16-36/37-45
- RIDADR
- UN 1230 3/PG 2
- WGK Germany
- 1
- HS Code
- 3822000000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H370Causes damage to organs
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P311Call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 21762
- Product name
- Leptomycin A
- Purity
- ≥99%
- Packaging
- 50μg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 21762
- Product name
- Leptomycin A
- Purity
- ≥99%
- Packaging
- 100μg
- Price
- $84
- Updated
- 2024/03/01
- Product number
- 21762
- Product name
- Leptomycin A
- Purity
- ≥99%
- Packaging
- 500μg
- Price
- $321
- Updated
- 2024/03/01
- Product number
- L329653
- Product name
- Leptomycin A
- Packaging
- 50μg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- BIL2100
- Product name
- Leptomycin A
- Packaging
- 100ug
- Price
- $95
- Updated
- 2021/12/16
LEPTOMYCIN A Chemical Properties,Usage,Production
Description
Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A inhibits Rev translocation, though less potently than leptomycin B with IC50 values of 0.8 and 0.1 nM, respectively after 7 hours. Rev export to the cytoplasm is required for HIV-1 replication. Leptomycin A was originally identified as an antifungal agent.
Uses
Leptomycin A is an antifungal antibiotic.
Uses
Leptomycin A, a methyl analogue of leptomycin B, is a minor component of the leptomycin complex produced by selected Streptomyces species. Leptomycin B is a potent inhibitor of the nuclear transport receptor CRM1. Leptomycin A is also likely to inhibit nuclear transport and may offer differences in exporter selectivity. Leptomycin A shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus.
Definition
ChEBI: A leptomycin having all-trans double bonds and a seventh methyl substituent at position 17.
LEPTOMYCIN A Preparation Products And Raw materials
Raw materials
Preparation Products
LEPTOMYCIN A Suppliers
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View Lastest Price from LEPTOMYCIN A manufacturers
- Product
- LeptoMycin A 87081-36-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-09
- Product
- LEPTOMYCIN A 87081-36-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-24