LEPTOMYCIN A

Product Name: LEPTOMYCIN A
CAS No.: 87081-36-5
Chemical Name: LEPTOMYCIN A
Synonyms: PD-118607;NSC 369326;Antibiotic PD-118607;Antibiotic ATS-1287A;LEPTOMYCIN A USP/EP/BP;QECBVZBMGUAZDL-DLWOFZAMSA-N;ATS 1287A, PD 118607, JildaMycin;19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid;19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid;(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-[(2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid
CBNumber: CB6972730
Molecular Formula: C32H46O6
Formula Weight: 526.7
MOL File: 87081-36-5.mol

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LEPTOMYCIN A Property

Flash point:: 9℃
storage temp.: -20°C
solubility: Ethanol: Soluble; Methanol: Soluble
form: methanol solution
color: Colorless to light yellow

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Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 16-36/37-45
RIDADR: UN 1230 3/PG 2
WGK Germany: 1
HS Code: 3822000000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21762
Product name: Leptomycin A
Purity: ≥99%
Packaging: 50μg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 21762
Product name: Leptomycin A
Purity: ≥99%
Packaging: 100μg
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 21762
Product name: Leptomycin A
Purity: ≥99%
Packaging: 500μg
Price: $321
Updated: 2024/03/01

TRC

Product number: L329653
Product name: Leptomycin A
Packaging: 50μg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: BIL2100
Product name: Leptomycin A
Packaging: 100ug
Price: $95
Updated: 2021/12/16

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LEPTOMYCIN A Chemical Properties,Usage,Production

Description

Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A inhibits Rev translocation, though less potently than leptomycin B with IC₅₀ values of 0.8 and 0.1 nM, respectively after 7 hours. Rev export to the cytoplasm is required for HIV-1 replication. Leptomycin A was originally identified as an antifungal agent.

Uses

Leptomycin A is an antifungal antibiotic.

Uses

Leptomycin A, a methyl analogue of leptomycin B, is a minor component of the leptomycin complex produced by selected Streptomyces species. Leptomycin B is a potent inhibitor of the nuclear transport receptor CRM1. Leptomycin A is also likely to inhibit nuclear transport and may offer differences in exporter selectivity. Leptomycin A shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus.

Definition

ChEBI: A leptomycin having all-trans double bonds and a seventh methyl substituent at position 17.

LEPTOMYCIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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LEPTOMYCIN A Suppliers

China 49 India 1 Switzerland 1 United Kingdom 1 United States 7 Global 59

Chembest Research Laboratories Limited

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Shanghai Xilong Biochemical Technology Co., Ltd.

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Lynnchem

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Novachemistry

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87081-36-5, LEPTOMYCIN ARelated Search:

Azithromycin Clindamycin Daptomycin Gentamicin Lincomycin Acetylspiramycin PD 124895 KAZUSAMYCIN A FROM STREPTOMYCES SP. LEPTOMYCIN A

ATS 1287A, PD 118607, JildaMycin

NSC 369326

2,10,12,16,18-Nonadecapentaenoicacid,19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-

19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid

19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid

Antibiotic ATS-1287A

Antibiotic PD-118607

PD-118607

QECBVZBMGUAZDL-DLWOFZAMSA-N

LEPTOMYCIN A USP/EP/BP

(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-[(2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid

87081-36-5

C32H46O6

ADC