ChemicalBook > CAS DataBase List > LEPTOMYCIN A

LEPTOMYCIN A

Product Name
LEPTOMYCIN A
CAS No.
87081-36-5
Chemical Name
LEPTOMYCIN A
Synonyms
PD-118607;NSC 369326;Antibiotic PD-118607;Antibiotic ATS-1287A;LEPTOMYCIN A USP/EP/BP;QECBVZBMGUAZDL-DLWOFZAMSA-N;ATS 1287A, PD 118607, JildaMycin;19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid;19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid;(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-[(2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid
CBNumber
CB6972730
Molecular Formula
C32H46O6
Formula Weight
526.7
MOL File
87081-36-5.mol
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LEPTOMYCIN A Property

Flash point:
9℃
storage temp. 
-20°C
solubility 
Ethanol: Soluble; Methanol: Soluble
form 
methanol solution
color 
Colorless to light yellow
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
16-36/37-45
RIDADR 
UN 1230 3/PG 2
WGK Germany 
1
HS Code 
3822000000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21762
Product name
Leptomycin A
Purity
≥99%
Packaging
50μg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
21762
Product name
Leptomycin A
Purity
≥99%
Packaging
100μg
Price
$84
Updated
2024/03/01
Cayman Chemical
Product number
21762
Product name
Leptomycin A
Purity
≥99%
Packaging
500μg
Price
$321
Updated
2024/03/01
TRC
Product number
L329653
Product name
Leptomycin A
Packaging
50μg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
BIL2100
Product name
Leptomycin A
Packaging
100ug
Price
$95
Updated
2021/12/16
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LEPTOMYCIN A Chemical Properties,Usage,Production

Description

Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A inhibits Rev translocation, though less potently than leptomycin B with IC50 values of 0.8 and 0.1 nM, respectively after 7 hours. Rev export to the cytoplasm is required for HIV-1 replication. Leptomycin A was originally identified as an antifungal agent.

Uses

Leptomycin A is an antifungal antibiotic.

Uses

Leptomycin A, a methyl analogue of leptomycin B, is a minor component of the leptomycin complex produced by selected Streptomyces species. Leptomycin B is a potent inhibitor of the nuclear transport receptor CRM1. Leptomycin A is also likely to inhibit nuclear transport and may offer differences in exporter selectivity. Leptomycin A shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus.

Definition

ChEBI: A leptomycin having all-trans double bonds and a seventh methyl substituent at position 17.

LEPTOMYCIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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LEPTOMYCIN A Suppliers

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87081-36-5, LEPTOMYCIN ARelated Search:

Azithromycin Clindamycin Daptomycin Gentamicin Lincomycin Acetylspiramycin PD 124895 KAZUSAMYCIN A FROM STREPTOMYCES SP. LEPTOMYCIN A

  • ATS 1287A, PD 118607, JildaMycin
  • NSC 369326
  • 2,10,12,16,18-Nonadecapentaenoicacid,19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-
  • 19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
  • 19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
  • Antibiotic ATS-1287A
  • Antibiotic PD-118607
  • PD-118607
  • QECBVZBMGUAZDL-DLWOFZAMSA-N
  • LEPTOMYCIN A USP/EP/BP
  • (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-[(2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid
  • 87081-36-5
  • C32H46O6
  • ADC