Sovilnesib

Product Name: Sovilnesib
CAS No.: 2410796-79-9
Chemical Name: Sovilnesib
Synonyms: AMG-650;AMG 650（Sovilnesib）;Sovilnesib;Sovilnesibum;Sovilnesib(AMG-650);Sovilnesib (Synonyms: AMG 650);Sovilnesib,AMG650,Inhibitor,inhibit,AMG 650,AMG-650,Microtubule/Tubulin;N-[2-(4,4-Difluoro-1-piperidyl)-6-methyl-4-pyrimidinyl]-4-(2-hydroxyethylsulfonamido)-2-(6-azaspiro[2.5]octan-6-yl)benzamide;N-(2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl)-4-((2-hydroxyethyl)sulfonamido)-2-(6-azaspiro[2.5]octan-6-yl)benzamide;Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[2-(4,4-difluoro-1-piperidinyl)-6-methyl-4-pyrimidinyl]-4-[[(2-hydroxyethyl)sulfonyl]amino]-
CBNumber: CB69768453
Molecular Formula: C26H34F2N6O4S
Formula Weight: 564.65
MOL File: 2410796-79-9.mol

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Sovilnesib Property

Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 7.48±0.10(Predicted)
InChIKey: KBDGEJDIHZDPHN-UHFFFAOYSA-N
SMILES: C(NC1C=C(C)N=C(N2CCC(F)(F)CC2)N=1)(=O)C1=CC=C(NS(CCO)(=O)=O)C=C1N1CCC2(CC2)CC1

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Hazard and Precautionary Statements (GHS)

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Sovilnesib Chemical Properties,Usage,Production

Description

Sovilnesib (AMG 650) is a kinesin-like protein KIF18A inhibitor (WO2020132648). Sovilnesib can be used for the research of cancer.

in vitro

Sovilnesib is a kinesin-like protein KIF18A inhibitor.

in vivo

Sovilnesib (AMG 650; 10-100 mg/kg; p.o. daily, for 45 d; female nude mice without thymus with OVCAR-3 xenografts) inhibits tumor growth, Lasting tumor regression and cure occurred in 50% of the animals, Sovilnesib has no apparent toxicity.

Clinical claims and research

Sovilnesib (AMG-650) is under development for the treatment of triple-negative breast cancer (TNBC), platinum-resistant high grade serous ovarian cancer, primary peritoneal cancer, fallopian tube cancer, serous endometrial cancer and other solid tumors with TP53 gene mutation (TP53MUT). The drug candidate is administered orally as tablet. It acts by targeting KIF18A.

Sovilnesib Preparation Products And Raw materials

Raw materials

Preparation Products

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Sovilnesib Suppliers

China 35 United States 1 Global 36

Zhejiang Brunova Technology Co., Ltd.

Tel: 13735468882 17857108485
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Energy Chemical

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NOTA Chemical (Shanghai) Co.,Ltd

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ShangHai Caerulum Pharma Discovery Co., Ltd.

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Shanghai Lollane Biological Technology Co.,Ltd.

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Jiaxing Deyi Chemical Co., Ltd.

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Shanghai SPAR pharmaceutical technology co., LTD

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Jilin Province Woda Biotechnology Co., Ltd.

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DC Chemicals

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Accela ChemBio Co.,Ltd.

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2410796-79-9, SovilnesibRelated Search:

LDC7559

Benzamide, 2-(6-azaspiro[2.5]oct-6-yl)-N-[2-(4,4-difluoro-1-piperidinyl)-6-methyl-4-pyrimidinyl]-4-[[(2-hydroxyethyl)sulfonyl]amino]-

AMG-650

Sovilnesib (Synonyms: AMG 650)

AMG 650（Sovilnesib）

Sovilnesib

Sovilnesib,AMG650,Inhibitor,inhibit,AMG 650,AMG-650,Microtubule/Tubulin

Sovilnesib(AMG-650)

N-(2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl)-4-((2-hydroxyethyl)sulfonamido)-2-(6-azaspiro[2.5]octan-6-yl)benzamide

N-[2-(4,4-Difluoro-1-piperidyl)-6-methyl-4-pyrimidinyl]-4-(2-hydroxyethylsulfonamido)-2-(6-azaspiro[2.5]octan-6-yl)benzamide

Sovilnesibum

2410796-79-9

C26H34F2N6O4S