LDC7559

Product Name: LDC7559
CAS No.: 2407782-01-6
Chemical Name: LDC7559
Synonyms: LDC7559;LDC7559 ，S9622;LDC7559, 10 mM in DMSO;Inhibitor,Pyroptosis,LDC7559,inhibit,LDC 7559,LDC-7559;Acetamide, N-[2-(2-methoxyphenyl)-4H,10H-pyrazolo[5,1-c][1,4]benzoxazepin-7-yl]-;N-(2-(2-Methoxyphenyl)-4H,10H-benzo[f]pyrazolo[5,1-c][1,4]oxazepin-7-yl)acetamide;N-(2-(2-Methoxyphenyl)-4,10-dihydrobenzo[f]pyrazolo[5,1-c][1,4]oxazepin-7-yl)acetamide
CBNumber: CB48096799
Molecular Formula: C20H19N3O3
Formula Weight: 349.38
MOL File: 2407782-01-6.mol

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LDC7559 Property

Boiling point:: 596.3±50.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 125 mg/mL (357.78 mM)
pka: 14.44±0.20(Predicted)
form: Solid
color: White to light yellow
InChI: InChI=1S/C20H19N3O3/c1-13(24)21-15-8-7-14-11-23-16(12-26-20(14)9-15)10-18(22-23)17-5-3-4-6-19(17)25-2/h3-10H,11-12H2,1-2H3,(H,21,24)
InChIKey: IFOIINXSFCQLOV-UHFFFAOYSA-N
SMILES: C(NC1C=C2OCC3=CC(C4=CC=CC=C4OC)=NN3CC2=CC=1)(=O)C

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0089815
Product name: LDC7559
Purity: 99.64%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0089815
Product name: LDC7559
Purity: 99.64%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0089815
Product name: LDC7559
Purity: 99.64%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0089815
Product name: LDC7559
Purity: 99.64%
Packaging: 100mg
Price: $2300
Updated: 2021/12/16

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LDC7559 Chemical Properties,Usage,Production

Description

LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages.

Uses

LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages [1].

in vitro

LDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human and murine GSDMD NT domains transfected into HEK293T cells.
LDC7559 functions directly through blocking the activity of the GSDMD NT domain, rather than interfering with the activation and cleavage process.

References

[1] Spel L, et al. Gasdermin D opens the way for NETs. Nat Rev Rheumatol. 2018 Dec;14(12):690-692. DOI:10.1038/s41584-018-0124-3
[2] Sollberger G, et al. Gasdermin D plays a vital role in the generation of neutrophil extracellular traps. Sci Immunol. 2018 Aug 24;3(26). pii: eaar6689. DOI:10.1126/sciimmunol.aar6689
[3] Ankit Pandeya, et al. Gasdermin D (GSDMD) as a New Target for the Treatment of Infection. Medchemcomm. 2019 Apr 4;10(5):660-667. DOI:10.1039/c9md00059c

LDC7559 Preparation Products And Raw materials

Raw materials

Preparation Products

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LDC7559 Suppliers

China 46 United States 3 Global 49

Nanjing Xinmeihe Pharmaceutical Co., Ltd.

Tel: 025-57672321 13739186949
Fax: 025-57672123
Email: yuanming@huashineltd.com
Country: China
ProdList: 490
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 89689
Advantage: 60

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2989
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9550
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1946
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Shanghai Han-Xiang Chemical Co., Ltd.

Tel: 15971444841
Fax: 18327183813
Email: amber@biochempartner.com
Country: China
ProdList: 3061
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
Advantage: 58

2407782-01-6, LDC7559Related Search:

Sovilnesib

Acetamide, N-[2-(2-methoxyphenyl)-4H,10H-pyrazolo[5,1-c][1,4]benzoxazepin-7-yl]-

LDC7559

Inhibitor,Pyroptosis,LDC7559,inhibit,LDC 7559,LDC-7559

N-(2-(2-Methoxyphenyl)-4,10-dihydrobenzo[f]pyrazolo[5,1-c][1,4]oxazepin-7-yl)acetamide

LDC7559, 10 mM in DMSO

LDC7559 ，S9622

N-(2-(2-Methoxyphenyl)-4H,10H-benzo[f]pyrazolo[5,1-c][1,4]oxazepin-7-yl)acetamide

2407782-01-6