ZLc002

Product Name: ZLc002
CAS No.: 308277-46-5
Chemical Name: ZLc002
Synonyms: ZLc002;EX-A5758;(S)-ZLc002;EX A5758,EXA5758;Methyl (3-methoxy-3-oxopropanoyl)-L-valinate;L-Valine, N-(3-methoxy-1,3-dioxopropyl)-, methyl ester
CBNumber: CB69933477
Molecular Formula: C10H17NO5
Formula Weight: 231.25
MOL File: 308277-46-5.mol

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ZLc002 Property

Boiling point:: 350.1±22.0 °C(Predicted)
Density: 1.115±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 46 mg/mL (198.92 mM);Ethanol: 46 mg/mL (198.92 mM)
pka: 12.22±0.46(Predicted)
form: Solid
color: Off-white to light yellow
Water Solubility: Water: 46 mg/mL (198.92 mM)
InChI: InChI=1S/C10H17NO5/c1-6(2)9(10(14)16-4)11-7(12)5-8(13)15-3/h6,9H,5H2,1-4H3,(H,11,12)/t9-/m0/s1
InChIKey: BWPKYDAJBOUZDX-VIFPVBQESA-N
SMILES: C(OC)(=O)[C@H](C(C)C)NC(=O)CC(OC)=O

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Hazard and Precautionary Statements (GHS)

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ZLc002 Chemical Properties,Usage,Production

Biological Activity

ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain.

Biological Functions

ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability. It could disrupt binding between nNOS and NOS1AP using ex-vivo, in vitro, and purified recombinant systems. In vitro, ZLc002 reduced coimmunoprecipitation of full-length NOS1AP and nNOS in cultured neurons and HEK293T cells co-expressing full-length nNOS and NOS1AP[1].

References

[1] Lee WH, et al. Mol Pain. 2018 Jan-Dec;14:1744806918801224.
[2] Wan-Hung Lee. “ZLc002, a putative small-molecule inhibitor of nNOS interaction with NOS1AP, suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability.” Molecular Pain 14 (2018): 1744806918801224.

ZLc002 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZLc002 Suppliers

China 16 United States 2 Global 18

Shanghai EFE Biological Technology Co., Ltd.

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Shanghai Han-Xiang Chemical Co., Ltd.

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Bide Pharmatech Ltd.

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TargetMol Chemicals Inc.

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308277-46-5, ZLc002Related Search:

L-Valine, N-(3-methoxy-1,3-dioxopropyl)-, methyl ester

EX-A5758

EX A5758,EXA5758

ZLc002

(S)-ZLc002

Methyl (3-methoxy-3-oxopropanoyl)-L-valinate

308277-46-5