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SR 31747

Product Name
SR 31747
CAS No.
132173-07-0
Chemical Name
SR 31747
Synonyms
SR 31747;SR 31747,SR31747;HKHPCMBPASXYGP-KVVVOXFISA-N;(Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)allyl)-N-ethylcyclohexanamine;3-(3-Chloro-4-cyclohexylphenyl)-N-cyclohexyl-N-ethyl-2(Z)-propenylaMine;(Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)allyl)-N-ethylcyclohexanamine hydrochloride;3-(3-Chloro-4-cyclohexylphenyl)-N-cyclohexyl-N-ethyl-2(Z)-propenylaMine hydrochloride;(Z)-N-[3-(3-CHLORO-4-CYCLOHEXYLPHENYL)PROP-2-ENYL]-N-ETHYLCYCLOHEXYLAMINE HYDROCHLORIDE
CBNumber
CB71011640
Formula Weight
0
MOL File
132173-07-0.mol
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SR 31747 Property

form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0007776
Product name
SR-31747
Purity
99.80%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0007776
Product name
SR-31747
Purity
99.80%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0007776
Product name
SR-31747
Purity
99.80%
Packaging
100mg
Price
$2250
Updated
2021/12/16
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SR 31747 Chemical Properties,Usage,Production

Uses

SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase[1][2].

in vivo

In vivo, SR-31747 dramatically blocks lipopolysaccharide-induced production of IL-1, IL-6 and TNF-α in a dose-dependent manner (ED50, 2 mg/kg). SR-31747 probably abrogated monokine production through an indirect mechanism that involves endogenous corticosteroids. This conclusion was supported by in vivo experiments that shows that: 1) ablation of corticosteroids by use of Mifepristone or adrenalectomy suppress the effect of SR-31747; 2) administration of SR-31747 induces an enhancement of the corticosterone level. SR-31747 improves the survival of animals with endotoxinic shock as a result of monokine inhibition[1].

References

[1] Derocq JM, et al. In vivo inhibition of endotoxin-induced pro-inflammatory cytokines production by the sigma ligand SR 31747. J Pharmacol Exp Ther. 1995 Jan;272(1):224-30. PMID:7815336
[2] Silve S, et al. The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae. Mol Cell Biol. 1996 Jun;16(6):2719-27. DOI:10.1128/MCB.16.6.2719

SR 31747 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR 31747 Suppliers

China 15 United States 5 Global 20
TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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32435
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Alchem Pharmtech,Inc.
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8485655694
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sales@alchempharmtech.com
Country
United States
ProdList
63687
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58
TargetMol Chemicals Inc.
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+17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
19962
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58
MedChemExpress
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
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APAC Pharmaceutical, LLC
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Email
sales@apacpharma.com
Country
United States
ProdList
6322
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132173-07-0, SR 31747Related Search:

N-Ethylcyclohexylamine 4-CYCLOHEXYLSTYRENE SR 31747

  • SR 31747
  • (Z)-N-[3-(3-CHLORO-4-CYCLOHEXYLPHENYL)PROP-2-ENYL]-N-ETHYLCYCLOHEXYLAMINE HYDROCHLORIDE
  • 3-(3-Chloro-4-cyclohexylphenyl)-N-cyclohexyl-N-ethyl-2(Z)-propenylaMine
  • 3-(3-Chloro-4-cyclohexylphenyl)-N-cyclohexyl-N-ethyl-2(Z)-propenylaMine hydrochloride
  • (Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)allyl)-N-ethylcyclohexanamine
  • HKHPCMBPASXYGP-KVVVOXFISA-N
  • (Z)-N-(3-(3-Chloro-4-cyclohexylphenyl)allyl)-N-ethylcyclohexanamine hydrochloride
  • SR 31747,SR31747
  • 132173-07-0