o-methylisourea
- Product Name
- o-methylisourea
- CAS No.
- 2440-60-0
- Chemical Name
- o-methylisourea
- Synonyms
- Methyl carbamimidate;o-methylisourea (abbreviate OMIU);o-methylisourea;o-Methylisouronium;Methoxyformamidine;ORTHO-METHYLISOUREA;24285-39-0 (Sulfate);29427-58-5 (Monosulfate);Fluorouracil Impurity 16;5329-33-9 (Hydrochloride)
- CBNumber
- CB71013558
- Molecular Formula
- C2H6N2O
- Formula Weight
- 74.08
- MOL File
- 2440-60-0.mol
o-methylisourea Property
- Melting point:
- 44-45 °C
- Boiling point:
- 66.9±23.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- solubility
- free base readily sol most organic solvents. Salts sol water, methanol, ethanol.
- pka
- pK1:9.72(＋1) (25°C)
N-Bromosuccinimide Price
- Product number
- B497138
- Product name
- MethylCarbamimidate
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CHM0078925
- Product name
- METHOXYMETHANIMIDAMIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $679.14
- Updated
- 2021/12/16
o-methylisourea Chemical Properties,Usage,Production
Uses
O-methylisourea can be used in the synthesis of heterocyclic compounds; it is a guanylation reagent and a selective alkylating agent.
Application
Methyl Carbamimidate is preparation of Ph (3-methoxy-1,2,4-thiadiazol-5-yl)carbamate from O-methylisourea hydrochloride.
Preparation
O-methylisourea hydrochloride is prepared in 69-80% yield by adding 1.15 equiv HCl(g) with ice cooling to cyanamide dissolved in excess anhydrous methanol. The free base is obtained from the salt using powdered KOH in a water-ether mixture or with sodium methoxide in methanol. The monoacetate salt can be prepared from the free base with 1 equiv of HOAc. Drying: vacuum desiccator over P2O5.
storage
Salts are hygroscopic and should be stored in a desiccator even for brief periods. Heating O-methylisourea to decomposition can liberate toxic fumes of NOx. Use in a fume hood.
o-methylisourea Preparation Products And Raw materials
Raw materials
Preparation Products
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