O-METHYLISOUREA SULFATE
Application- Product Name
- O-METHYLISOUREA SULFATE
- CAS No.
- 29427-58-5
- Chemical Name
- O-METHYLISOUREA SULFATE
- Synonyms
- OMIHS;isourea suL;Einecs 249-622-6;OMI HYDROGEN SULFATE;O-METHYLISOUREA SULFATE;O-Methylisourea bisulfate;2-METHYLPSEUDOUREA SULFATE;O-METHYLISOUREA SULFATE SALT;Methyl carbamimidate sulfate;o-Methylisourea sulfate ,99%
- CBNumber
- CB3210916
- Molecular Formula
- C2H8N2O5S
- Formula Weight
- 172.16
- MOL File
- 29427-58-5.mol
O-METHYLISOUREA SULFATE Property
- Melting point:
- 118-120 °C (lit.)
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- White to off-white Solid
- BRN
- 3722928
- InChI
- InChI=1S/C2H6N2O.H2O4S/c1-5-2(3)4;1-5(2,3)4/h1H3,(H3,3,4);(H2,1,2,3,4)
- InChIKey
- MDFRYRPNRLLJHT-UHFFFAOYSA-N
- SMILES
- S(=O)(O)(O)=O.C(=N)(N)OC
- CAS DataBase Reference
- 29427-58-5(CAS DataBase Reference)
- EPA Substance Registry System
- Carbamimidic acid, methyl ester, sulfate (1:1) (29427-58-5)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M53701
- Product name
- o-Methylisourea bisulfate
- Purity
- 99%
- Packaging
- 25g
- Price
- $104
- Updated
- 2025/07/31
- Product number
- M53701
- Product name
- o-Methylisourea bisulfate
- Purity
- 99%
- Packaging
- 5g
- Price
- $38.3
- Updated
- 2023/06/20
- Product number
- 099807
- Product name
- Methyl carbamimidate sulfate
- Purity
- 95+%
- Packaging
- 25g
- Price
- $39
- Updated
- 2021/12/16
- Product number
- 2995AB
- Product name
- o-Methylisourea bisulfate
- Packaging
- 25g
- Price
- $44
- Updated
- 2021/12/16
- Product number
- 099807
- Product name
- Methyl carbamimidate sulfate
- Purity
- 95+%
- Packaging
- 100g
- Price
- $120
- Updated
- 2021/12/16
O-METHYLISOUREA SULFATE Chemical Properties,Usage,Production
Application
O-methylisourea hydrogen sulfate is an amino salt that can be used as an intermediate for 5-fluorouracil. It can be used as an organic synthesis intermediate and a pharmaceutical intermediate, and is mainly used in laboratory research and development processes and chemical and pharmaceutical synthesis processes.
Chemical Properties
White or off-white solid
Synthesis
67-56-1
420-04-2
29427-58-5
Preparation of Example 39: Synthesis of 1.3-dimethoxycarbonyl-O-methylisourea Procedure: 1. MeOH-H2SO4 solution was prepared by slowly adding sulfuric acid (112.7 g, 0.97 mol) to pre-cooled methanol (150 mL). 2. In another flask, cyanamide (50 g, 1.19 mol) was dissolved in methanol (100 mL) and cooled to about 5° C. in an ice water bath and cooled to about 5 °C. 3. The MeOH-H2SO4 solution was slowly added dropwise to the methanol solution of cyanamide while maintaining the reaction temperature at no more than 10 °C for 2 h. 4. After the dropwise addition was completed, the reaction mixture was continued to be stirred at the same temperature for 1 h. 5. At the end of the reaction, the solvent was removed by concentration in vacuum to afford O-methylisourea hydrogensulfate as a thick, syrupy product, assuming a yield of 1.5 mmol. syrupy product, assuming quantitative yield, which was used directly in the subsequent reaction.
Purification Methods
Recrystallise the salt from MeOH/Et2O (327g of salt dissolved in 1L of MeOH and 2.5L of Et2O is added) [Fearing & Fox J Am Chem Soc 76 4382 1954 ]. The picrate has m 192o [Odo et al. J Org Chem 23 1319 1958]. [Beilstein 3 IV 143.]
References
[1] Patent: US2004/254181, 2004, A1. Location in patent: Page 19
O-METHYLISOUREA SULFATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from O-METHYLISOUREA SULFATE manufacturers
- Product
- O-METHYLISOUREA SULFATE 29427-58-5
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-18