H-GAMMA-ABU-OBZL P-TOSYLATE
- Product Name
- H-GAMMA-ABU-OBZL P-TOSYLATE
- CAS No.
- 26727-22-0
- Chemical Name
- H-GAMMA-ABU-OBZL P-TOSYLATE
- Synonyms
- 4-Abu-obzl.tos;H-GABA-OBzl·TosOH;H-g-Abu-OBzl·TosOH;H-γ-Abu-OBzl·TosOH;H-γ-Abu-Obzl.TosOH;H-ABU(4)-OBZL TOS-OH;Hγ-Abu-OBzl·p-tosylate;H-GAMMA-ABU-OBZL TOS-OH;H-GABA-OBzl · p-tosylate;gamma-Abu-OBzl p-tosylate
- CBNumber
- CB7101939
- Molecular Formula
- C18H23NO5S
- Formula Weight
- 365.44
- MOL File
- 26727-22-0.mol
H-GAMMA-ABU-OBZL P-TOSYLATE Property
- storage temp.
- Sealed in dry,Room Temperature
N-Bromosuccinimide Price
- Product number
- FA56176
- Product name
- gamma-Aminobutyric acid benzyl ester p-tosylate
- Packaging
- 25g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 093954
- Product name
- Benzyl 4-aminobutanoate 4-methylbenzenesulfonate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $189
- Updated
- 2021/12/16
- Product number
- J95736
- Product name
- Benzyl4-aminobutanoate4-methylbenzenesulfonate
- Packaging
- 100g
- Price
- $260
- Updated
- 2021/12/16
- Product number
- FA56176
- Product name
- gamma-Aminobutyric acid benzyl ester p-tosylate
- Packaging
- 50g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 14954
- Product name
- γ-Aminobutyricacidbenzylesterp-tosylate,≥98%(HPLC)
- Purity
- ≥98%(HPLC)
- Packaging
- 100G
- Price
- $343.62
- Updated
- 2021/12/16
H-GAMMA-ABU-OBZL P-TOSYLATE Chemical Properties,Usage,Production
Synthesis
104-15-4
100-51-6
56-12-2
26727-22-0
A suspension of γ-aminobutyric acid (GABA) (3.50 g, 0.034 mol), benzyl alcohol (7.30 g, 7 mL, 0.068 mol), and p-toluenesulfonic acid monohydrate (PTSA) (7.10 g, 0.037 mol) was heated to reflux for 5 hr in toluene (200 mL), and the resulting water was removed by azeotropic distillation. Upon completion of the reaction, the mixture was concentrated to one-third of the original volume and the product was subsequently precipitated by the addition of ether (100 mL). The precipitate was collected by filtration, dissolved in methanol (60 mL) and reprecipitated by adding ether (100 mL) again. After filtration, it was dried to obtain 4-methylbenzenesulfonate, 4-aminobutyric acid benzyl ester (12.30 g, 99% yield) in the form of white crystals. The melting point of the product was 106.2-106.7 °C (determined in ether); Infrared spectrum (ATR): 3100, 3039, 2942, 1732, 1642, 1532, 1188, 1125 cm^-1; ^1H NMR (200 MHz, CD3OD): δ = 7.71 (d, J = 8.0 Hz, 2H, HPTSA), and 7.37-7.30 (m, 5H, HCAr), 7.20 (d, J=8.4 Hz, 2H, HPTSA), 5.11 (s, 2H, H2CBn), 2.95 (t, J=7.5 Hz, 2H, H2C(4)GABA), 2.47 (t, J=7.3 Hz, 2H, H2C(2)GABA), 2.33 (s 3H, H3CPTSA), 1.92 (quint, J=7.4 Hz, 2H, H2C(3)GABA) ppm; ^13C NMR (50 MHz, CD3OD): δ=173.83 (CO2Bn), 143.35, 141.82, 137.43, 129.91, 129.59, 129.30, 126.91 (CAr), 67.44 (CH2Bn), 40.00 (CH2(4)GABA), 31.59 (CH2(2)GABA), 23.65 (CH2(3)GABA), 21.30 (CH3PTSA) ppm; Mass Spectra (ESI): calculated values of C11H16NO2 ([M+H]+): 194.1181, measured value: 194.1167.
References
[1] Tetrahedron, 2017, vol. 73, # 50, p. 7073 - 7078
[2] Organic and Biomolecular Chemistry, 2009, vol. 7, # 11, p. 2327 - 2337
[3] RSC Advances, 2015, vol. 5, # 81, p. 66339 - 66354
[4] Patent: WO2014/59158, 2014, A1. Location in patent: Page/Page column 38-39
[5] Tetrahedron Letters, 2015, vol. 56, # 48, p. 6803 - 6806
H-GAMMA-ABU-OBZL P-TOSYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from H-GAMMA-ABU-OBZL P-TOSYLATE manufacturers
- Product
- 4-Abu-obzl.tos 26727-22-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-03-29