ChemicalBook > CAS DataBase List > 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole

Product Name
2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole
CAS No.
117977-21-6
Chemical Name
2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole
Synonyms
rabeprazole sulphide;Rabeprazole Related CoMpound E;abeprazole Sulfide;Rabeprazole Sulfide; H 295/43;(+)-Limacine;Rabeprazole-3;(+)-Fangchinoline;Rabeprazole USP RC E;Rabeprazole Thioether
CBNumber
CB7102567
Molecular Formula
C18H21N3O2S
Formula Weight
343.44
MOL File
117977-21-6.mol
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2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole Property

Melting point:
120.5-121.50C
Boiling point:
546.4±60.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
10.60±0.10(Predicted)
color 
White to Off-White
InChI
InChI=1S/C18H21N3O2S/c1-13-16(19-9-8-17(13)23-11-5-10-22-2)12-24-18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21)
InChIKey
BSXAHDOWMOSVAP-UHFFFAOYSA-N
SMILES
C1(SCC2=NC=CC(OCCCOC)=C2C)NC2=CC=CC=C2N=1
CAS DataBase Reference
117977-21-6(CAS DataBase Reference)
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Safety

HS Code 
2933998350
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3124
Product name
Rabeprazole Related Compound E
Purity
pharmaceutical secondary standard, certified reference material
Packaging
50MG
Price
$574
Updated
2025/07/31
TCI Chemical
Product number
R0098
Product name
Rabeprazole Sulfide
Purity
>98.0%(HPLC)(T)
Packaging
200mg
Price
$43
Updated
2025/07/31
TCI Chemical
Product number
R0098
Product name
Rabeprazole Sulfide
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$129
Updated
2025/07/31
TRC
Product number
R070510
Product name
Rabeprazole Sulfide
Packaging
25mg
Price
$200
Updated
2021/12/16
TRC
Product number
R070510
Product name
Rabeprazole Sulfide
Packaging
1g
Price
$820
Updated
2021/12/16
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2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole Chemical Properties,Usage,Production

Chemical Properties

Off-White Crystalline Powder

Uses

Rabeprazole Sulfide (Rabeprazole EP Impurity B) is a metabolite of Rabeprazole (R070500).

Synthesis

118175-10-3

134469-07-1

117977-21-6

General procedure for the synthesis of 2-[[[4-(3-methoxypropoxy)-3-methylpyrimidin-2-yl]methyl]thio]-1H-benzimidazole from 2-hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine and 1H-benzo[d]imidazole-2-thiol: 100 g of 2-hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine ( 473.35 mmol) in a 2L three-necked flask, 1 L of tetrahydrofuran was added as solvent, followed by 71.10 g of 1H-benzo[d]imidazole-2-thiol (473.35 mmol) and 136.58 g of triphenylphosphine (520.69 mmol). Stirring was turned on and the reaction temperature was controlled at 0 °C. Slowly 90.678 g of diethyl azodicarboxylate (520.69 mmol) was added dropwise. After the dropwise addition, the reaction was maintained for 5h to 10h, during which the reaction progress was monitored by TLC. Upon completion of the reaction, the tetrahydrofuran was evaporated to dryness by rotary evaporator, and the resulting crude product was purified by recrystallization from methanol to give 130.0 g of the target product 2-[[[4-(3-methoxypropoxy)-3-methylpyrimidin-2-yl]methyl]thio]-1H-benzimidazole in 80% yield.

References

[1] Patent: CN106674198, 2017, A. Location in patent: Paragraph 0020-0021

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole Suppliers

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View Lastest Price from 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole 117977-21-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-20
Shaanxi Dideu New Materials Co. Ltd
Product
2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole 117977-21-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-10
Dideu Industries Group Limited
Product
2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole 117977-21-6
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-26

117977-21-6, 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazoleRelated Search:

1-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]-2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole RaBeprazole Impurity H (S)-Rabeprazole Sodium Salt N-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl] Rabeprazole Sulfone 1H-BENZIMIDAZOLE-2-SULFONIC ACID 4-Desmethoxypropoxyl-4-chloro Rabeprazole Sulfone 4-Desmethoxypropoxyl-4-chloro Rabeprazole 4-Nitro-2,3-lutidine-N-oxide Rabeprazole IMpurity G Rebeprazole sodium Rabeprazole 4-[(1H-Benzimidazol-2-yl)oxy]-3-methyl-2-pyridinecarboxylic Acid Discontinued See: B203960 Rabeprazole Impurity 2 2-[(4-Chloro-3-Methyl-2-Pyridinyl-methyl)thio]-1H-Benzimidazole Rabeprazole Impurity 2 Rabeprazole Related CoMpound A Rabeprazole Impurity 8 RABEPRAZOLE N-OXIDE

  • 2-[(4-METHOXYPROPOXY-3-METHYL-2-PYRIDINYL)-METHYLTHIO]-BENZIMIDAZOLE
  • 2-[[(3-METHYL-4-(3-METHOXYPROPOXY)PYRIDINYL)METHYL]THIO]-1H-BENZIMIDAZOLE
  • Rabeprazole IMpurity F
  • 2-(((4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl)Methyl)thio)-1H-benzo[d]iMidazole
  • rabeprazole sulphide
  • 2-[[4-(3-Methoxypropoxy)-3-Methyl-2-pyridyl]Methylthio]benziMidazole
  • Rabeprazole Sulfide IMpurity
  • 2-[[4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl]Methylsulfanyl]-1h-benziMidazole
  • Rabeprazole Related Compound E (25 mg) (2-{[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio}benzimidazole)
  • Rabeprazole USP RC E
  • Rabeprazole Related CoMpound E
  • Rabeprazole EP Impurity B
  • Rabeprazole Related Compound E (2-{[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio}benzimidazole)
  • 2-[[4-(3-Methoxypropoxy)-3-methyl-pyridin-2-yl]methylthio]benzoimidazole
  • 2-[[(4-(3-Methoxypropoxy)- 3-methyl-2-pyridinyl)-2-methyl]thio]- 1H-benzimidazole
  • 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)
  • Rabeprazole Impurity 7
  • Rabeprazole Sodium Impurity Ⅲ:2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole
  • Rabeprazole EP Impurity B (Rabeprazole Sulfide)
  • Rabeprazole-3
  • 2-[[[4-(3-Methoxypropoxy)-3-methylpyridinyl] methyl]thio]- 1H-benzimidazole (RabeSulphide)
  • Rabeprazole USP Related Compound E
  • 2-[[[4-(3-Methoxypropoxy)-3-methylpiridine-2-yl]methyl]thio]-1H-benzimidazole
  • 2-[[[4-(3-METHOXYPROPOXY)3-METHYL-2-PYRIDINYL] METHYL]THIO]1HBENZIMIDAZOLE
  • 2-[[[4-(3-METHOXY PROPOXY)-3-METHYL PYRIDINE-2-YL]METHYL] THIO]-1H-BENZIMIDAZOLE
  • 2-([4-(3-METHOXYPROPOXY)-3-METHYLPYRIDINE-2-YL]-METHYTHIO)1H-BENZIMIDAZOLE
  • 2-[[4-(3-METHOXYPROPOXY)-3-METHYLPYRIDIN-2-YL]METHYLTHIO}-1H-BENZIMIDAZOLE
  • 2-[{4-(3-MethoxyPropoxy)-3-MethylPyridine-2-Yi}-Methylthio]-1H-Benzimidazole
  • H 295/43
  • 2-[[[3-Methyl-4-(3-methoxypropoxy)-2-pyridyl]methyl]thio]-1H-benzimidazole
  • Rabeprazole Sulfide
  • Rabeprazole Thioether
  • 2-{[4-(3-methoxypropoxy)-3-met
  • Rebeprazole thioether
  • 1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-
  • 2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine hydro
  • 2-{[4-(3-Methoxypropoxy)-3-Methylpyridine-2-yl]Met
  • 2-({[4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl]Methyl}sulfanyl)-1H-1,3-benzodiazole
  • Rabeprazole Sulfide &gt
  • 2-[[[4-(3-Methoxypropoxy)-3-methyl-
  • Rabeprazole Impurity 3（Rabeprazole EP Impurity B）
  • 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole ISO 9001：2015 REACH
  • abeprazole Sulfide
  • Rabeprazole EP Impurity B/ Rabeprazole Related Compound E (Rabeprazole Sulfide)
  • Rabeprazole USP Related Compound E.doc
  • 2-{[4-(3-Methoxypropoxy)-3-Methylpyridine-2-Yl]-Methythio}-1...
  • Rabeprazole sulphideQ: What is Rabeprazole sulphide Q: What is the CAS Number of Rabeprazole sulphide Q: What is the storage condition of Rabeprazole sulphide
  • 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole/Rabeprazole sulfide
  • Rabeprazole Related Compound E (2-{[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio}benzimidazol (1598064)
  • (+)-Fangchinoline
  • (+)-Limacine
  • Rabeprazole Sulfide (Rabeprazole Impurity)
  • 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2- yl]methylthio}-1H-benzimidazole (Rabe Sulphide)
  • 2-[[[4-(3-Methoxypropoxy)-3-Methylpyridinyl] Methyl]Thio]- 1H-Benzimidazole (Sulp)
  • 2-(((4-(3-methoxypropoxy)-3-methylpyridine-2-yl) methyl) thio)-1H-benzo[d]imidazole
  • Ribeprazole condensate
  • 2-[[[4-(3-Methoxy Propoxy-3-mthyl-2Pyridyl] Methyl]Thio]-1H-Benzimidazole
  • Rabeprazole Sulfide / Rabeprazole Related Compound-E