ChemicalBook > CAS DataBase List > SODIUM CAMPTOTHECIN

SODIUM CAMPTOTHECIN

Product Name: SODIUM CAMPTOTHECIN
CAS No.: 25387-67-1
Chemical Name: SODIUM CAMPTOTHECIN
Synonyms: Fda 1660;CaMphotecin sodiuM;camptothecinsodium;SODIUM CAMPTOTHECIN;camptothecinesodium;sodium (S)-2-hydroxy-2;camptothecin,sodiumsalt;Irinotecan Impurity 18 HCl;Irinotecan Hydroxyl Acid 18;20(s)-camptothecinsodiumsalt
CBNumber: CB7103362
Molecular Formula: C20H17N2NaO5
Formula Weight: 388.35
MOL File: 25387-67-1.mol

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SODIUM CAMPTOTHECIN Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Solid
color: Light yellow to light brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: S614558
Product name: sodium camptothecin
Packaging: 2.5g
Price: $1230
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: ING0005426
Product name: SODIUM CAMPTOTHECIN
Purity: 95.00%
Packaging: 1G
Price: $1030.84
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: ING0005426
Product name: SODIUM CAMPTOTHECIN
Purity: 95.00%
Packaging: 5G
Price: $1697.85
Updated: 2021/12/16

Ambeed

Product number: A294776
Product name: sodium camptothecin
Purity: 95%
Packaging: 250mg
Price: $29
Updated: 2021/12/16

Ambeed

Product number: A294776
Product name: sodium camptothecin
Purity: 95%
Packaging: 1g
Price: $70
Updated: 2021/12/16

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SODIUM CAMPTOTHECIN Chemical Properties,Usage,Production

Uses

Sodium Camptothecin is the salt form of Camptothecin.

Synthesis

7689-03-4

25387-67-1

1.045 g of (S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (CPT lactone) was accurately weighed in a sterile round bottom flask (250 mL). Water equivalent to 20% of the final volume was added to give a final concentration of CPT of 25 mM.Subsequently, 3.34 g of 1N NaOH solution was added to the inhomogeneous mixture, ensuring that the molar ratio of CPT to NaOH was 1:1.05.The mixture was stirred vigorously at 50°C until complete dissolution, a process that took about 1 h, indicating that the CPT lactone had been quantitatively converted to its water-soluble carboxylate form. It was shown that raising the temperature to 90°C further accelerated this conversion process. Although stirring for 4-6 hours has no significant effect on the chemical stability of CPT, it is recommended that this stirring time be maintained to ensure a complete reaction. Upon completion of the reaction, the solution is cooled to room temperature and can be stored under light conditions at 4°C for at least 24 hours. (Long-term storage stability of CPT-Na stock solutions will be discussed subsequently.) The pH of the final solution should be maintained between 10 and 11.5.

References

[1] Patent: EP1547582, 2005, A1. Location in patent: Page/Page column 10
[2] Patent: EP1547580, 2005, A1. Location in patent: Page/Page column 13

SODIUM CAMPTOTHECIN Preparation Products And Raw materials

Raw materials

Preparation Products

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C20H17N2O5Na

C20H18N2NaO5