SODIUM CAMPTOTHECIN
- Product Name
- SODIUM CAMPTOTHECIN
- CAS No.
- 25387-67-1
- Chemical Name
- SODIUM CAMPTOTHECIN
- Synonyms
- Fda 1660;CaMphotecin sodiuM;camptothecinsodium;SODIUM CAMPTOTHECIN;camptothecinesodium;sodium (S)-2-hydroxy-2;camptothecin,sodiumsalt;Irinotecan Impurity 18 HCl;Irinotecan Hydroxyl Acid 18;20(s)-camptothecinsodiumsalt
- CBNumber
- CB7103362
- Molecular Formula
- C20H17N2NaO5
- Formula Weight
- 388.35
- MOL File
- 25387-67-1.mol
SODIUM CAMPTOTHECIN Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Solid
- color
- Light yellow to light brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S614558
- Product name
- sodium camptothecin
- Packaging
- 2.5g
- Price
- $1230
- Updated
- 2021/12/16
- Product number
- ING0005426
- Product name
- SODIUM CAMPTOTHECIN
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1697.85
- Updated
- 2021/12/16
- Product number
- ING0005426
- Product name
- SODIUM CAMPTOTHECIN
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1030.84
- Updated
- 2021/12/16
- Product number
- A294776
- Product name
- sodium camptothecin
- Purity
- 95%
- Packaging
- 250mg
- Price
- $29
- Updated
- 2021/12/16
- Product number
- A294776
- Product name
- sodium camptothecin
- Purity
- 95%
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
SODIUM CAMPTOTHECIN Chemical Properties,Usage,Production
Uses
Sodium Camptothecin is the salt form of Camptothecin.
Synthesis
7689-03-4
25387-67-1
1.045 g of (S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (CPT lactone) was accurately weighed in a sterile round bottom flask (250 mL). Water equivalent to 20% of the final volume was added to give a final concentration of CPT of 25 mM.Subsequently, 3.34 g of 1N NaOH solution was added to the inhomogeneous mixture, ensuring that the molar ratio of CPT to NaOH was 1:1.05.The mixture was stirred vigorously at 50°C until complete dissolution, a process that took about 1 h, indicating that the CPT lactone had been quantitatively converted to its water-soluble carboxylate form. It was shown that raising the temperature to 90°C further accelerated this conversion process. Although stirring for 4-6 hours has no significant effect on the chemical stability of CPT, it is recommended that this stirring time be maintained to ensure a complete reaction. Upon completion of the reaction, the solution is cooled to room temperature and can be stored under light conditions at 4°C for at least 24 hours. (Long-term storage stability of CPT-Na stock solutions will be discussed subsequently.) The pH of the final solution should be maintained between 10 and 11.5.
References
[1] Patent: EP1547582, 2005, A1. Location in patent: Page/Page column 10
[2] Patent: EP1547580, 2005, A1. Location in patent: Page/Page column 13
SODIUM CAMPTOTHECIN Preparation Products And Raw materials
Raw materials
Preparation Products
SODIUM CAMPTOTHECIN Suppliers
- Tel
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- Fax
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- standards@synzeal.com
- Country
- India
- ProdList
- 6514
- Advantage
- 58
- Tel
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- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
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